HCSGD entry for SRD5A2

1. General information

Official gene symbolSRD5A2
Entrez ID6716
Gene full namesteroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)
Other gene symbols
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:00038653-oxo-5-alpha-steroid 4-dehydrogenase activityIEAmolecular_function
GO:0005789Endoplasmic reticulum membraneTAScellular_component
GO:0006702Androgen biosynthetic processTASbiological_process
GO:0007267Cell-cell signalingTASbiological_process
GO:0008202Steroid metabolic processTASbiological_process
GO:0008209Androgen metabolic processIDAbiological_process
GO:0008584Male gonad developmentIMPbiological_process
GO:0009917Sterol 5-alpha reductase activityIDAmolecular_function
GO:0016021Integral component of membraneIEAcellular_component
GO:0030154Cell differentiationIEAbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0047751Cholestenone 5-alpha-reductase activityIEAmolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.30677617110.93602346800.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0745917810
GSE13712_SHEARUp0.0708099808
GSE13712_STATICDown-0.1096066520
GSE19018Down-0.1560067918
GSE19899_A1Down-0.0615274737
GSE19899_A2Up0.0409685002
PubMed_21979375_A1Up0.0649738190
PubMed_21979375_A2Up0.0279548833
GSE35957Up0.0663838928
GSE36640Up0.2363108241
GSE54402Up0.0045173157
GSE9593Up0.1285008820
GSE43922Up0.0342842564
GSE24585Down-0.0038302725
GSE37065Down-0.0746532137
GSE28863_A1Up0.5961158594
GSE28863_A2Up0.4057337388
GSE28863_A3Up0.1390475650
GSE28863_A4Up0.1230919506
GSE48662Up0.1677037341

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

DutasterideDB01126 APRD00385
FinasterideDB01216 APRD00632 | DB07774
SpironolactoneDB00421 APRD01234

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.