HCSGD entry for SQLE
1. General information
| Official gene symbol | SQLE |
|---|---|
| Entrez ID | 6713 |
| Gene full name | squalene epoxidase |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004506 | Squalene monooxygenase activity | IEA NAS TAS | molecular_function |
| GO:0005789 | Endoplasmic reticulum membrane | TAS | cellular_component |
| GO:0006695 | Cholesterol biosynthetic process | TAS | biological_process |
| GO:0006725 | Cellular aromatic compound metabolic process | IEA | biological_process |
| GO:0008203 | Cholesterol metabolic process | IEA | biological_process |
| GO:0010033 | Response to organic substance | IEA | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0016126 | Sterol biosynthetic process | NAS | biological_process |
| GO:0043231 | Intracellular membrane-bounded organelle | IEA | cellular_component |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0050660 | Flavin adenine dinucleotide binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0188585692 | 0.2329541317 | 0.3360706838 | 0.9298734759 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.6440580955 |
| GSE13712_SHEAR | Down | -0.2961293073 |
| GSE13712_STATIC | Down | -0.5131385128 |
| GSE19018 | Down | -0.4067669709 |
| GSE19899_A1 | Up | 0.7087734523 |
| GSE19899_A2 | Up | 1.3707463090 |
| PubMed_21979375_A1 | Down | -0.2676178252 |
| PubMed_21979375_A2 | Up | 0.9295916472 |
| GSE35957 | Down | -0.1829720932 |
| GSE36640 | Up | 1.1480192482 |
| GSE54402 | Up | 0.1026361340 |
| GSE9593 | Up | 0.2692473706 |
| GSE43922 | Up | 0.5644263642 |
| GSE24585 | Down | -0.6760674025 |
| GSE37065 | Up | 0.1804329196 |
| GSE28863_A1 | Up | 0.0605442583 |
| GSE28863_A2 | Up | 0.9227610175 |
| GSE28863_A3 | Down | -1.0113909406 |
| GSE28863_A4 | Up | 0.0007980359 |
| GSE48662 | Down | -0.2298490203 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Naftifine | DB00735 | APRD01131 |
| Terbinafine | DB00857 | APRD00508 |
| NM100060 | DB04927 | - |
| Ellagic Acid | DB08846 | DB08468 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT018458 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-let-7e-5p | MIMAT0000066 | MIRT051529 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
