HCSGD entry for SPR
1. General information
| Official gene symbol | SPR |
|---|---|
| Entrez ID | 6697 |
| Gene full name | sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase) |
| Other gene symbols | SDR38C1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004033 | Aldo-keto reductase (NADP) activity | TAS | molecular_function |
| GO:0004757 | Sepiapterin reductase activity | ISS TAS | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006729 | Tetrahydrobiopterin biosynthetic process | TAS | biological_process |
| GO:0006809 | Nitric oxide biosynthetic process | IDA | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0046209 | Nitric oxide metabolic process | TAS | biological_process |
| GO:0050661 | NADP binding | TAS | molecular_function |
| GO:0050999 | Regulation of nitric-oxide synthase activity | TAS | biological_process |
| GO:0055114 | Oxidation-reduction process | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0068272178 | 0.9392775540 | 0.2161663070 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.4399500534 |
| GSE13712_SHEAR | Up | 0.0280694485 |
| GSE13712_STATIC | Up | 0.1781655577 |
| GSE19018 | Down | -0.2767349070 |
| GSE19899_A1 | Down | -0.0510907504 |
| GSE19899_A2 | Up | 0.9767539495 |
| PubMed_21979375_A1 | Up | 1.0785324257 |
| PubMed_21979375_A2 | Up | 1.5402268517 |
| GSE35957 | Up | 0.4462039416 |
| GSE36640 | Up | 1.4024240784 |
| GSE54402 | Up | 0.0442711639 |
| GSE9593 | Up | 0.3557634185 |
| GSE43922 | Up | 0.3446850497 |
| GSE24585 | Down | -0.6980896743 |
| GSE37065 | Up | 0.2377001253 |
| GSE28863_A1 | Down | -0.0532395623 |
| GSE28863_A2 | Up | 0.7420907407 |
| GSE28863_A3 | Up | 0.3383941713 |
| GSE28863_A4 | Down | -0.1360319194 |
| GSE48662 | Up | 0.4423097573 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Oxaloacetate Ion | DB02637 | EXPT02406 |
| 2'-Monophosphoadenosine 5'-Diphosphoribose | DB03461 | EXPT02293 |
| Biopterin | DB03886 | EXPT00708 |
| N-Acetyl Serotonin | DB04275 | EXPT00570 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-let-7b-5p | MIMAT0000063 | MIRT032464 | Proteomics | Functional MTI (Weak) | 18668040 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25466460 | A sensitive method for selectively detecting insulin-like growth factor-binding protein 7 (IGFBP7) over a wide range of concentrations based on the surface plasmon resonance (SPR) biosensing techniques is described |
| 25466460 | The SPR sensing method is based on the selective interaction of IGFBP7 with specific anti-IGFBP7 proteins on a gold thin film, which was covalently bound to the Fc-binding domain of protein G on a mixed self-assembled monolayer composed of DSNHS (S2(CH2)11COO(CH2)2COO-(N-hydroxysuccinimide)) and mercaptoundecanol, and effect of this on changes in the SPR profiles |
| 25466460 | The SPR sensing method is based on the selective interaction of IGFBP7 with specific anti-IGFBP7 proteins on a gold thin film, which was covalently bound to the Fc-binding domain of protein G on a mixed self-assembled monolayer composed of DSNHS (S2(CH2)11COO(CH2)2COO-(N-hydroxysuccinimide)) and mercaptoundecanol, and effect of this on changes in the SPR profiles |
| 25466460 | The limit of detection (LOD) of the SPR biosensor was determined to be 10 ng/ml, which is a reasonable LOD value for biomedical applications |
| 25466460 | The SPR biosensor also shows specificity for IGFBP7 compared to that for biologically relevant interleukin (IL) derivatives including IL4, IL23, IL29, and IFG1 |
| 25466460 | Finally, the level secretion of IGFBP7 from cancer cells detected by the SPR biosensor showed a good correlation with a commercial kit using an IGFBP7 enzyme-linked immunosorbent assay |
| 25466460 | The findings reported herein indicate that the SPR biosensor for IGFBP7 would be applicable in a wide variety of biomedical fields |
| 22871222 | Their interactions with telomeric quadruplex and duplex DNA were examined by using the fluorescence resonance energy transfer (FRET) melting assay, surface plasmon resonance (SPR), circular dichroism spectroscopy (CD), and molecular modeling studies |
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