HCSGD entry for SPAST
1. General information
| Official gene symbol | SPAST |
|---|---|
| Entrez ID | 6683 |
| Gene full name | spastin |
| Other gene symbols | ADPSP FSP2 SPG4 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001578 | Microtubule bundle formation | IDA | biological_process |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005768 | Endosome | IDA | cellular_component |
| GO:0005783 | Endoplasmic reticulum | IDA | cellular_component |
| GO:0005813 | Centrosome | IEA | cellular_component |
| GO:0005819 | Spindle | IEA | cellular_component |
| GO:0005874 | Microtubule | IEA | cellular_component |
| GO:0006200 | ATP catabolic process | IDA | biological_process |
| GO:0006888 | ER to Golgi vesicle-mediated transport | IMP | biological_process |
| GO:0007109 | Cytokinesis, completion of separation | IMP | biological_process |
| GO:0007409 | Axonogenesis | IEA | biological_process |
| GO:0008017 | Microtubule binding | IDA | molecular_function |
| GO:0008219 | Cell death | IEA | biological_process |
| GO:0008568 | Microtubule-severing ATPase activity | IDA | molecular_function |
| GO:0015630 | Microtubule cytoskeleton | IDA | cellular_component |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0030496 | Midbody | IDA | cellular_component |
| GO:0031117 | Positive regulation of microtubule depolymerization | IEA | biological_process |
| GO:0031410 | Cytoplasmic vesicle | IDA | cellular_component |
| GO:0034214 | Protein hexamerization | IDA | biological_process |
| GO:0043014 | Alpha-tubulin binding | IPI | molecular_function |
| GO:0048471 | Perinuclear region of cytoplasm | IEA | cellular_component |
| GO:0048487 | Beta-tubulin binding | IPI | molecular_function |
| GO:0051013 | Microtubule severing | IDA | biological_process |
| GO:0051260 | Protein homooligomerization | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9350803047 | 0.0275366969 | 0.9999902473 | 0.3157489983 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0123387797 |
| GSE13712_SHEAR | Down | -0.2467356433 |
| GSE13712_STATIC | Down | -0.0601985929 |
| GSE19018 | Down | -0.3501858929 |
| GSE19899_A1 | Down | -0.1829223754 |
| GSE19899_A2 | Down | -0.3441579585 |
| PubMed_21979375_A1 | Up | 0.1309337993 |
| PubMed_21979375_A2 | Down | -0.1022066481 |
| GSE35957 | Up | 0.4938308745 |
| GSE36640 | Up | 0.0941541438 |
| GSE54402 | Down | -0.2062979828 |
| GSE9593 | Up | 0.2340354335 |
| GSE43922 | Up | 0.0127163095 |
| GSE24585 | Down | -0.7169054760 |
| GSE37065 | Up | 0.0629419683 |
| GSE28863_A1 | Down | -0.1908599473 |
| GSE28863_A2 | Up | 0.3786858726 |
| GSE28863_A3 | Down | -0.9744972792 |
| GSE28863_A4 | Down | -0.5185978043 |
| GSE48662 | Down | -0.2559275937 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-132-3p | MIMAT0000426 | MIRT021774 | Microarray | Functional MTI (Weak) | 17612493 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
