HCSGD entry for SPARC

1. General information

Official gene symbolSPARC
Entrez ID6678
Gene full namesecreted protein, acidic, cysteine-rich (osteonectin)
Other gene symbolsON
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001503OssificationIEAbiological_process
GO:0002576Platelet degranulationTASbiological_process
GO:0005509Calcium ion bindingIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005518Collagen bindingTASmolecular_function
GO:0005576Extracellular regionNAS TAScellular_component
GO:0005578Proteinaceous extracellular matrixIEA TAScellular_component
GO:0005604Basement membraneIEAcellular_component
GO:0005615Extracellular spaceIEAcellular_component
GO:0005634NucleusIEAcellular_component
GO:0005737CytoplasmIEAcellular_component
GO:0007165Signal transductionIEAbiological_process
GO:0007507Heart developmentIEAbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0009629Response to gravityIEAbiological_process
GO:0010288Response to lead ionIEAbiological_process
GO:0030168Platelet activationTASbiological_process
GO:0030198Extracellular matrix organizationTASbiological_process
GO:0030324Lung developmentIEAbiological_process
GO:0031012Extracellular matrixIEAcellular_component
GO:0031093Platelet alpha granule lumenTAScellular_component
GO:0031988Membrane-bounded vesicleIEAcellular_component
GO:0032496Response to lipopolysaccharideIEAbiological_process
GO:0033591Response to L-ascorbic acidIEAbiological_process
GO:0034097Response to cytokineIEAbiological_process
GO:0042060Wound healingIEAbiological_process
GO:0042127Regulation of cell proliferationIEAbiological_process
GO:0043434Response to peptide hormoneIEAbiological_process
GO:0045471Response to ethanolIEAbiological_process
GO:0046686Response to cadmium ionIEAbiological_process
GO:0048839Inner ear developmentIEAbiological_process
GO:0050840Extracellular matrix bindingIEAmolecular_function
GO:0051384Response to glucocorticoidIEAbiological_process
GO:0051591Response to cAMPIEAbiological_process
GO:0051592Response to calcium ionIEAbiological_process
GO:0060348Bone developmentIEAbiological_process
GO:0071363Cellular response to growth factor stimulusIEAbiological_process
GO:0071682Endocytic vesicle lumenTAScellular_component
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.87013294710.00967987920.99999024730.1948280153

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.2669025292
GSE13712_SHEARDown-0.2469602543
GSE13712_STATICDown-0.2574651501
GSE19018Up0.5894224318
GSE19899_A1Down-0.8072735163
GSE19899_A2Down-1.1153489765
PubMed_21979375_A1Down-2.3461774666
PubMed_21979375_A2Down-1.1166941820
GSE35957Up0.4506971716
GSE36640Up0.4422575539
GSE54402Down-1.1710119783
GSE9593Up0.3400748429
GSE43922Down-0.2327033078
GSE24585Up0.3107277703
GSE37065Down-0.2372397478
GSE28863_A1Down-0.0446219686
GSE28863_A2Down-0.1019620436
GSE28863_A3Up0.0686873342
GSE28863_A4Down-0.3436961592
GSE48662Down-0.0315432689

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-29c-3pMIMAT0000681MIRT001922Luciferase reporter assay//Reporter assay;OtherFunctional MTI18390668
hsa-miR-29a-3pMIMAT0000086MIRT006175qRT-PCRFunctional MTI (Weak)22864815
hsa-miR-192-5pMIMAT0000222MIRT004126MicroarrayFunctional MTI (Weak)16822819
hsa-miR-10a-5pMIMAT0000253MIRT047698CLASHFunctional MTI (Weak)23622248
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    • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-29a-3pMIMAT0000086NAhsa-miR-29a18390668
hsa-miR-204-5pMIMAT0000265NAhsa-miR-20420369013
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 8 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

20554622Levels of apolipoprotein J (Apo J), SM22, and osteonectin (SPARC) mRNA were determined by real-time PCR analysis
20554622RESULTS: TGF-beta2 increased SA-beta-Gal activity, lipid peroxidation, and the mRNA expressions of Apo J, SM22, and SPARC
20164124We previously revealed that secreted protein acidic and rich in cysteine (SPARC), a matricellular protein, may function as a modulator of chemotherapy sensitivity by enhancing apoptosis
20164124However, CPT-11-resistant cells exposed to endogenous or exogenous SPARC can also be triggered into cellular senescence
20164124Knock down of p16(INK4A) reduces drug-induced senescence in all cells, but knock down and overexpression of p53 modulates senescence only in cells exposed to SPARC
20164124Furthermore, treatment of mice with SPARC and CPT-11 leads to significantly increased cellular senescence and tumor regression
20164124The chemosensitizing effects of SPARC in CRCs are, therefore, probably mediated in part by activating cellular senescence
18425358Thirdly, the mRNA levels of three senescence-associated genes, fibronectin, osteonectin and SM22, also increased
16893911The impaired osteoblast differentiation in Nf1+/- MSPC is consistent with the reduced expression of osteoblast markers at the mRNA level, including osteocalcin and osteonectin
11060295In this work, we show that transforming growth factor-beta1 (TGF-beta1) regulates the induction of several of these biomarkers in SIPS: cellular morphology, senescence-associated beta-galactosidase activity, increase in the steady-state level of fibronectin, apolipoprotein J, osteonectin, and SM22 mRNA
11060295In the presence of each of these antibodies, the steady-state level of fibronectin, osteonectin, apolipoprotein J, and SM22 mRNA is no more increased at 72 h after stress
10958924Effects of ageing on proliferative ability, and the expressions of secreted protein, acidic and rich in cysteine (SPARC) and osteoprotegerin (osteoclastogenesis inhibitory factor) in cultures of human periodontal ligament cells
10958924Secreted protein, acidic and rich in cysteine (SPARC) has been suggested to play an important role in wound repair and mineralization
10958924Levels of SPARC mRNA in HPL cells increased with cellular ageing in vivo
10958924The changes in proliferative ability and the mRNA levels of SPARC and OPG/OCIF with cellular ageing in vitro were similar to those with ageing in vivo
10958924Furthermore, the increase in SPARC with ageing may be related to changes in metabolism of periodontal ligament that occur with ageing
9570922Construction of cDNA libraries from two conditional cell lines and application of differential screening and subtractive hybridization techniques have resulted in the cloning of eight senescence-induced genes (SGP-2/Apo J, alpha 1-procollagen, osteonectin, fibronectin, SM22, cytochrome C oxidase, GTP-alpha, and a novel gene) and a senescence-repressed gene (FRS-2)
9080393Characterization of IGFBP-3, PAI-1 and SPARC mRNA expression in senescent fibroblasts
9080393The RNA species encoded by IGFBP-3 (insulin-like growth factor binding protein-3), PAI-1 (plasminogen activator inhibitor-1) and SPARC (secreted protein-acidic and rich in cysteine; a
9080393Characterization of the rates of transcription and the levels of message stability of these genes in early passage (young) versus late passage (old) HDF revealed that IGFBP-3, PAI-1 and SPARC are coordinately overexpressed but not regulated by a unique or simple mechanism encompassing all three transcripts
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