HCSGD entry for DST

1. General information

Official gene symbolDST
Entrez ID667
Gene full namedystonin
Other gene symbolsBP240 BPA BPAG1 CATX-15 CATX15 D6S1101 DMH DT HSAN6 MACF2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000226Microtubule cytoskeleton organizationIDAbiological_process
GO:0003779Actin bindingIEAmolecular_function
GO:0005178Integrin bindingIPImolecular_function
GO:0005509Calcium ion bindingIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005604Basement membraneTAScellular_component
GO:0005634NucleusIDAcellular_component
GO:0005635Nuclear envelopeIEAcellular_component
GO:0005737CytoplasmIDA ISScellular_component
GO:0005789Endoplasmic reticulum membraneIEAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005856CytoskeletonIEAcellular_component
GO:0005882Intermediate filamentIEAcellular_component
GO:0005938Cell cortexIEAcellular_component
GO:0007010Cytoskeleton organizationIMPbiological_process
GO:0007050Cell cycle arrestIEAbiological_process
GO:0007155Cell adhesionIEAbiological_process
GO:0007229Integrin-mediated signaling pathwayNASbiological_process
GO:0007409AxonogenesisIEAbiological_process
GO:0008022Protein C-terminus bindingIPImolecular_function
GO:0008090Retrograde axon cargo transportIEAbiological_process
GO:0009611Response to woundingIDAbiological_process
GO:0009925Basal plasma membraneNAScellular_component
GO:0015629Actin cytoskeletonIDA IEAcellular_component
GO:0015630Microtubule cytoskeletonIDAcellular_component
GO:0016021Integral component of membraneIEAcellular_component
GO:0016023Cytoplasmic membrane-bounded vesicleIDAcellular_component
GO:0030011Maintenance of cell polarityIMPbiological_process
GO:0030018Z discIDA IEAcellular_component
GO:0030056HemidesmosomeIDA TAScellular_component
GO:0030198Extracellular matrix organizationTASbiological_process
GO:0030424AxonIDA IEAcellular_component
GO:0031110Regulation of microtubule polymerization or depolymerizationIEAbiological_process
GO:0031122Cytoplasmic microtubule organizationIEAbiological_process
GO:0031252Cell leading edgeIDAcellular_component
GO:0031581Hemidesmosome assemblyIDAbiological_process
GO:0031673H zoneIEAcellular_component
GO:0035371Microtubule plus-endIDAcellular_component
GO:0042803Protein homodimerization activityIDAmolecular_function
GO:0045104Intermediate filament cytoskeleton organizationIEP ISS NASbiological_process
GO:0045111Intermediate filament cytoskeletonIDAcellular_component
GO:0048870Cell motilityIMPbiological_process
GO:0051010Microtubule plus-end bindingIDAmolecular_function
GO:0060053Neurofilament cytoskeletonIEAcellular_component
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.13108966600.33259922120.73507416401.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0810535487
GSE13712_SHEARUp0.1845249057
GSE13712_STATICUp0.0702748105
GSE19018Up0.1885544502
GSE19899_A1Down-0.0439841727
GSE19899_A2Down-0.1525898272
PubMed_21979375_A1Down-0.5891150964
PubMed_21979375_A2Up0.0273096627
GSE35957Up0.2511807112
GSE36640Up0.2473423924
GSE54402Down-0.3276022856
GSE9593Up0.2961125005
GSE43922Down-0.1955035709
GSE24585Down-0.2660292309
GSE37065Up0.1800480845
GSE28863_A1Up1.1999475877
GSE28863_A2Up1.3168683792
GSE28863_A3Down-0.5550735760
GSE28863_A4Down-0.2455030906
GSE48662Down-0.1935720751

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT018347MicroarrayFunctional MTI (Weak)18185580
hsa-miR-215-5pMIMAT0000272MIRT024665MicroarrayFunctional MTI (Weak)19074876
hsa-miR-192-5pMIMAT0000222MIRT026612MicroarrayFunctional MTI (Weak)19074876
hsa-miR-32-5pMIMAT0000090MIRT028321SequencingFunctional MTI (Weak)20371350
hsa-miR-615-3pMIMAT0003283MIRT040309CLASHFunctional MTI (Weak)23622248
hsa-miR-484MIMAT0002174MIRT042022CLASHFunctional MTI (Weak)23622248
hsa-miR-218-5pMIMAT0000275MIRT046995CLASHFunctional MTI (Weak)23622248
hsa-miR-26a-5pMIMAT0000082MIRT050193CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

25207595Bisphenol A (BPA) is a widely utilized endocrine disruptor capable of mimicking endogenous hormones, employed in the manufacture of numerous consumer products, thereby interfering with physiological cellular functions
25207595Recent research has shown that BPA alters epigenetic cellular mechanisms in mammals and may be correlated to enhanced cellular senescence
25207595Here, the effects of BPA at 10 ng/mL and 1 microg/mL, concentrations found in human samples, were analyzed on HT29 human colon adenocarcinona cell line and Human Umbilical Vein Endothelial Cells (HUVEC)
25207595Quantitative Real-Time Polymerase Chain Reaction (qRT-PCR) transcriptional analysis of the Long Interspersed Element-1 (LINE-1) retroelement showed that BPA induces global transcription deregulation in both cell lines, although with more pronounced effects in HUVEC cells
25207595Importantly, cell viability assays and transcriptional analysis indicated that prolonged BPA exposure affects aging processes in senescent HUVEC
25207595To our knowledge this is the first report that BPA interferes with senescence in primary vascular endothelial cells, therefore, suggesting its association to the etiology of age-related human pathologies, such as atherosclerosis
22258036The carcinogenic activity of bisphenol A (BPA) is responsible for stimulating growth in estrogen-dependent breast cancer tissues, cell lines and rodent studies
22258036Exposure to BPA for 1 week at the early stage at passage 8 increased the proliferation and sphere size of HMEC at the later stage up to passage 16, suggesting that BPA has the capability to modulate cell growth in breast epithelial cells
22258036Our findings in the HMEC model suggested that the genetic and epigenetic alterations by BPA might damage HMEC function and result in complex activities related to cell proliferation and senescence, playing a role in mammary carcinogenesis
8866734In comparison with the young En(a-) red blood cell membranes, the number and the distribution density of lectin receptor sites on the old ones for Limulus polyphemus (LPA), Canavalia ensiformis (Con A), Triticum vulgaris (WGA) and Bauhinia purpurea (BPA) were significantly lower
8866734It is thought that En(a-) red blood cell ageing is accompanied by elimination of some sialoglycoconjugates which have affinity for LPA, Con A, WGA and BPA, whereas En(a-) red blood cells lack glycophorin A
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