HCSGD entry for SP1

1. General information

Official gene symbol	SP1
Entrez ID	6667
Gene full name	Sp1 transcription factor
Other gene symbols
Links to Entrez Gene	Links to Entrez Gene

2. Neighbors in the network

3. Gene ontology annotation

GO ID	GO term	Evidence	Category
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding	ISS	molecular_function
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding	IEA	molecular_function
GO:0000987	Core promoter proximal region sequence-specific DNA binding	IEA	molecular_function
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	IEA	molecular_function
GO:0001103	RNA polymerase II repressing transcription factor binding	ISS	molecular_function
GO:0001503	Ossification	IEA	biological_process
GO:0001829	Trophectodermal cell differentiation	IEA	biological_process
GO:0001889	Liver development	IEA	biological_process
GO:0001892	Embryonic placenta development	IEA	biological_process
GO:0003677	DNA binding	IDA	molecular_function
GO:0003690	Double-stranded DNA binding	IDA IEA	molecular_function
GO:0003700	Sequence-specific DNA binding transcription factor activity	IDA	molecular_function
GO:0005515	Protein binding	IPI	molecular_function
GO:0005634	Nucleus	IC IDA IEA	cellular_component
GO:0005654	Nucleoplasm	TAS	cellular_component
GO:0005730	Nucleolus	IDA	cellular_component
GO:0005737	Cytoplasm	IEA	cellular_component
GO:0006351	Transcription, DNA-templated	TAS	biological_process
GO:0006355	Regulation of transcription, DNA-templated	IDA	biological_process
GO:0006367	Transcription initiation from RNA polymerase II promoter	TAS	biological_process
GO:0007179	Transforming growth factor beta receptor signaling pathway	TAS	biological_process
GO:0008022	Protein C-terminus binding	IPI	molecular_function
GO:0008134	Transcription factor binding	IPI	molecular_function
GO:0010467	Gene expression	TAS	biological_process
GO:0016032	Viral process	IEA	biological_process
GO:0030219	Megakaryocyte differentiation	IEA	biological_process
GO:0030324	Lung development	IEA	biological_process
GO:0032993	Protein-DNA complex	IEA	cellular_component
GO:0035035	Histone acetyltransferase binding	IEA	molecular_function
GO:0035326	Enhancer binding	IEA	molecular_function
GO:0042803	Protein homodimerization activity	IDA	molecular_function
GO:0042826	Histone deacetylase binding	IPI	molecular_function
GO:0043353	Enucleate erythrocyte differentiation	IEA	biological_process
GO:0043425	BHLH transcription factor binding	ISS	molecular_function
GO:0043565	Sequence-specific DNA binding	IDA	molecular_function
GO:0043923	Positive regulation by host of viral transcription	IDA	biological_process
GO:0044212	Transcription regulatory region DNA binding	IDA	molecular_function
GO:0044255	Cellular lipid metabolic process	TAS	biological_process
GO:0044281	Small molecule metabolic process	TAS	biological_process
GO:0045893	Positive regulation of transcription, DNA-templated	IDA	biological_process
GO:0045944	Positive regulation of transcription from RNA polymerase II promoter	IDA TAS	biological_process
GO:0046872	Metal ion binding	IEA	molecular_function
GO:0048596	Embryonic camera-type eye morphogenesis	IEA	biological_process
GO:0048706	Embryonic skeletal system development	IEA	biological_process
GO:0060136	Embryonic process involved in female pregnancy	IEA	biological_process
GO:0060216	Definitive hemopoiesis	IEA	biological_process
GO:0071837	HMG box domain binding	IPI	molecular_function

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4. Expression levels in datasets

Meta-analysis result

p-value up	p-value down	FDR up	FDR down
0.3785265947	0.1531089814	0.9999902473	0.7551844857

Individual experiment result
( "-" represent NA in the specific microarray platform )

Data source	Up or down	Log fold change
GSE11954	Down	-0.2706241928
GSE13712_SHEAR	Down	-0.0928907525
GSE13712_STATIC	Down	-0.1048869483
GSE19018	Down	-0.0770999749
GSE19899_A1	Down	-0.4106519255
GSE19899_A2	Down	-0.8510174925
PubMed_21979375_A1	Down	-0.4954309673
PubMed_21979375_A2	Down	-0.1096483089
GSE35957	Down	-0.0559568388
GSE36640	Down	-0.8051807223
GSE54402	Down	-0.0517873637
GSE9593	Up	0.1984071598
GSE43922	Up	0.0014931095
GSE24585	Up	0.2362882176
GSE37065	Up	0.1452243693
GSE28863_A1	Up	0.9149772926
GSE28863_A2	Up	0.5531076307
GSE28863_A3	Down	-0.2059516895
GSE28863_A4	Up	0.1414068014
GSE48662	Up	0.1757398236

5. Regulation relationships with compounds/drugs/microRNAs

Compounds

Not regulated by compounds

Drugs

Not regulated by drugs

MicroRNAs

mirTarBase

MiRNA_name	mirBase ID	miRTarBase ID	Experiment	Support type	References (Pubmed ID)
hsa-miR-29b-3p	MIMAT0000100	MIRT000445	Immunoblot//Luciferase reporter assay//qRT-PCR	Functional MTI	19913496
hsa-miR-29b-3p	MIMAT0000100	MIRT000445	qRT-PCR//ChIP//Western blot	Functional MTI	20385359
hsa-miR-29b-3p	MIMAT0000100	MIRT000445	Luciferase reporter assay	Functional MTI	19211935
hsa-miR-21-5p	MIMAT0000076	MIRT006236	Luciferase reporter assay//Western blot	Functional MTI	22034194
hsa-miR-27a-3p	MIMAT0000084	MIRT002403	Western blot	Functional MTI	18006846
hsa-miR-27a-3p	MIMAT0000084	MIRT002403	Western blot;qRT-PCR	Functional MTI	20382698
hsa-miR-124-3p	MIMAT0000422	MIRT002660	Microarray	Functional MTI (Weak)	15685193
hsa-miR-124-3p	MIMAT0000422	MIRT002660	Proteomics;Microarray	Functional MTI (Weak)	18668037
hsa-miR-218-5p	MIMAT0000275	MIRT004246	Immunoblot//Luciferase reporter assay//qRT-PCR	Functional MTI	19913496
hsa-miR-149-5p	MIMAT0000450	MIRT007014	Luciferase reporter assay	Functional MTI	22821729
hsa-miR-149-5p	MIMAT0000450	MIRT007014	Luciferase reporter assay	Functional MTI	22819824
hsa-miR-22-3p	MIMAT0000077	MIRT007329	Luciferase reporter assay	Functional MTI	23529765
hsa-miR-22-3p	MIMAT0000077	MIRT007329	Reporter assay	Functional MTI	21502362
hsa-miR-335-5p	MIMAT0000765	MIRT017513	Reporter assay;Western blot	Functional MTI	21618216
hsa-miR-16-5p	MIMAT0000069	MIRT031577	Sequencing	Functional MTI (Weak)	20371350
hsa-miR-1	MIMAT0000416	MIRT035536	Luciferase reporter assay	Functional MTI	22911796
hsa-miR-133a-3p	MIMAT0000427	MIRT035537	Luciferase reporter assay	Functional MTI	22911796
hsa-miR-625-5p	MIMAT0003294	MIRT039599	CLASH	Functional MTI (Weak)	23622248
hsa-miR-99b-5p	MIMAT0000689	MIRT044192	CLASH	Functional MTI (Weak)	23622248
hsa-miR-186-5p	MIMAT0000456	MIRT045067	CLASH	Functional MTI (Weak)	23622248
hsa-miR-125a-5p	MIMAT0000443	MIRT045732	CLASH	Functional MTI (Weak)	23622248
hsa-let-7f-5p	MIMAT0000067	MIRT051372	CLASH	Functional MTI (Weak)	23622248
hsa-let-7b-5p	MIMAT0000063	MIRT052264	CLASH	Functional MTI (Weak)	23622248
hsa-let-7a-5p	MIMAT0000062	MIRT052453	CLASH	Functional MTI (Weak)	23622248

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mirRecord

No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.

Navigator

1.General information
2.Neighbors in the network
3.Gene Ontology Annotation
4.Expression levels
5.Regulation
6.Text-mining results

HCSGD entry for SP1

1. General information

2. Neighbors in the network

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

4. Expression levels in datasets

Meta-analysis result

Individual experiment result ( "-" represent NA in the specific microarray platform )

( "-" represent NA in the specific microarray platform )

5. Regulation relationships with compounds/drugs/microRNAs

Compounds

Drugs

MicroRNAs

mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.

Navigator

Individual experiment result
( "-" represent NA in the specific microarray platform )