HCSGD entry for SOX3

1. General information

Official gene symbolSOX3
Entrez ID6658
Gene full nameSRY (sex determining region Y)-box 3
Other gene symbolsGHDX MRGH PHP PHPX SOXB
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000979RNA polymerase II core promoter sequence-specific DNA bindingISSmolecular_function
GO:0001106RNA polymerase II transcription corepressor activityISSmolecular_function
GO:0003677DNA bindingTASmolecular_function
GO:0005634NucleusIEAcellular_component
GO:0006366Transcription from RNA polymerase II promoterISSbiological_process
GO:0007417Central nervous system developmentTASbiological_process
GO:0007423Sensory organ developmentISSbiological_process
GO:0007530Sex determinationIMPbiological_process
GO:0009887Organ morphogenesisIEAbiological_process
GO:0021854Hypothalamus developmentISSbiological_process
GO:0021983Pituitary gland developmentISSbiological_process
GO:0045665Negative regulation of neuron differentiationISSbiological_process
GO:0048515Spermatid differentiationIEAbiological_process
GO:0060009Sertoli cell developmentIEAbiological_process
GO:0060324Face developmentISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.23532595650.92501823260.91885692031.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0327524271
GSE13712_SHEARDown-0.2331782090
GSE13712_STATICUp0.0162002779
GSE19018Down-0.0419137275
GSE19899_A1Up0.0263486683
GSE19899_A2Up0.1743423340
PubMed_21979375_A1Down-0.0266872017
PubMed_21979375_A2Down-0.0675840356
GSE35957Up0.0467352803
GSE36640Up0.1438847018
GSE54402Down-0.0989796149
GSE9593Down-0.0010070713
GSE43922Up0.1322178414
GSE24585Up0.2648463755
GSE37065Down-0.0526953851
GSE28863_A1Up0.0240597734
GSE28863_A2Up0.0258347878
GSE28863_A3Up0.3458671598
GSE28863_A4Up0.1002579960
GSE48662Up1.4563281707

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-26b-5pMIMAT0000083MIRT030124MicroarrayFunctional MTI (Weak)19088304
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.