HCSGD entry for SOX1
1. General information
| Official gene symbol | SOX1 |
|---|---|
| Entrez ID | 6656 |
| Gene full name | SRY (sex determining region Y)-box 1 |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001046 | Core promoter sequence-specific DNA binding | IDA | molecular_function |
| GO:0001764 | Neuron migration | IEA | biological_process |
| GO:0002089 | Lens morphogenesis in camera-type eye | IEA | biological_process |
| GO:0003677 | DNA binding | NAS | molecular_function |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | NAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | NAS | cellular_component |
| GO:0006325 | Chromatin organization | NAS | biological_process |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006355 | Regulation of transcription, DNA-templated | NAS | biological_process |
| GO:0021521 | Ventral spinal cord interneuron specification | IEA | biological_process |
| GO:0021884 | Forebrain neuron development | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5663206223 | 0.8831653775 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0198136602 |
| GSE13712_SHEAR | Down | -0.1622630344 |
| GSE13712_STATIC | Down | -0.0978821447 |
| GSE19018 | Up | 0.1281920659 |
| GSE19899_A1 | Down | -0.0412005088 |
| GSE19899_A2 | Up | 0.1138415353 |
| PubMed_21979375_A1 | Up | 0.0797036065 |
| PubMed_21979375_A2 | Down | -0.0470125362 |
| GSE35957 | Up | 0.1037149489 |
| GSE36640 | Up | 0.0520656056 |
| GSE54402 | Up | 0.0442561119 |
| GSE9593 | Up | 0.0244600145 |
| GSE43922 | Up | 0.1490117766 |
| GSE24585 | Up | 0.0341147802 |
| GSE37065 | Down | -0.0807219806 |
| GSE28863_A1 | Down | -0.0589473457 |
| GSE28863_A2 | Down | -0.0103618797 |
| GSE28863_A3 | Up | 0.5764366057 |
| GSE28863_A4 | Down | -0.0423773662 |
| GSE48662 | Up | 0.0467221754 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT017005 | Microarray | Functional MTI (Weak) | 18185580 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25427424 | SOX1 down-regulates beta-catenin and reverses malignant phenotype in nasopharyngeal carcinoma |
| 25427424 | Previous studies have demonstrated that the developmental gene sex-determining region Y (SRY)-box 1 (SOX1) inhibits cervical and liver tumorigenesis by interfering with the Wnt/beta-catenin signaling pathway |
| 25427424 | However, the role of SOX1 in NPC remains unclear |
| 25427424 | This study investigates the function of SOX1 in NPC pathogenesis |
| 25427424 | RESULTS: Down-regulation of SOX1 was detected in NPC cell lines and tissues |
| 25427424 | Besides, quantitative methylation-specific polymerase chain reaction revealed that SOX1 promoter was hypermethylated in NPC cell lines |
| 25427424 | Ectopic expression of SOX1 in NPC cells suppressed colony formation, proliferation and migration in vitro and impaired tumor growth in nude mice |
| 25427424 | Restoration of SOX1 expression significantly reduced epithelial-mesenchymal transition, enhanced cell differentiation and induced cellular senescence |
| 25427424 | Conversely, transient knockdown of SOX1 by siRNA in these cells partially restored cell proliferation and colony formation |
| 25427424 | Notably, SOX1 was found to physically interact with beta-catenin and reduce its expression independent of proteasomal activity, leading to inhibition of Wnt/beta-catenin signaling and decreased expression of downstream target genes |
| 25427424 | CONCLUSIONS: SOX1 decreases the expression of beta-catenin in a proteasome-independent manner and reverses the malignant phenotype in NPC cells |
| 22767186 | SOX1 functions as a tumor suppressor by antagonizing the WNT/beta-catenin signaling pathway in hepatocellular carcinoma |
| 22767186 | SOX1 encodes a transcription factor involved in the regulation of embryonic development and cell fate determination |
| 22767186 | In this study, we confirmed via quantitative methylation-specific polymerase chain reaction that SOX1 was frequently downregulated through promoter hypermethylation in HCC cells and tissues |
| 22767186 | Overexpression of SOX1 by a constitutive or inducible approach could suppress cell proliferation, colony formation, and invasion ability in HCC cell lines, as well as tumor growth in nonobese diabetic/severe combined immunodeficiency mice |
| 22767186 | We used a T cell factor (TCF)-responsive luciferase reporter assay and western blot analysis to prove that SOX1 could regulate TCF-responsive transcriptional activity and inhibit the expression of Wnt downstream genes |
| 22767186 | Furthermore, we used glutathione S-transferase pull-down, co-immunoprecipitation, and confocal microscopy to demonstrate that SOX1 could interact with beta-catenin but not with the beta-catenin/TCF complex |
| 22767186 | Moreover, restoration of the expression of SOX1 induces significant cellular senescence in Hep3B cells |
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