HCSGD entry for SNCA

1. General information

Official gene symbolSNCA
Entrez ID6622
Gene full namesynuclein, alpha (non A4 component of amyloid precursor)
Other gene symbolsNACP PARK1 PARK4 PD1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000287Magnesium ion bindingIDAmolecular_function
GO:0001774Microglial cell activationIEAbiological_process
GO:0001921Positive regulation of receptor recyclingIDAbiological_process
GO:0001933Negative regulation of protein phosphorylationIEAbiological_process
GO:0001956Positive regulation of neurotransmitter secretionIEAbiological_process
GO:0001963Synaptic transmission, dopaminergicIEAbiological_process
GO:0005504Fatty acid bindingIDAmolecular_function
GO:0005507Copper ion bindingIDAmolecular_function
GO:0005509Calcium ion bindingIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005543Phospholipid bindingIEAmolecular_function
GO:0005576Extracellular regionTAScellular_component
GO:0005634NucleusIDAcellular_component
GO:0005640Nuclear outer membraneIEAcellular_component
GO:0005737CytoplasmIDA IEAcellular_component
GO:0005739MitochondrionIEAcellular_component
GO:0005791Rough endoplasmic reticulumIEAcellular_component
GO:0005794Golgi apparatusIEAcellular_component
GO:0005829CytosolIDA IEAcellular_component
GO:0005840RibosomeIEAcellular_component
GO:0005856CytoskeletonIEAcellular_component
GO:0005886Plasma membraneIDA IEAcellular_component
GO:0005938Cell cortexIDAcellular_component
GO:0006631Fatty acid metabolic processIEAbiological_process
GO:0006638Neutral lipid metabolic processIEAbiological_process
GO:0006644Phospholipid metabolic processIEAbiological_process
GO:0006919Activation of cysteine-type endopeptidase activity involved in apoptotic processIDAbiological_process
GO:0007006Mitochondrial membrane organizationIEAbiological_process
GO:0007568AgingIEAbiological_process
GO:0008017Microtubule bindingIEAmolecular_function
GO:0008021Synaptic vesicleIEAcellular_component
GO:0008198Ferrous iron bindingIDAmolecular_function
GO:0008270Zinc ion bindingIDAmolecular_function
GO:0008344Adult locomotory behaviorIEAbiological_process
GO:0010040Response to iron(II) ionIDAbiological_process
GO:0010517Regulation of phospholipase activityIDAbiological_process
GO:0010642Negative regulation of platelet-derived growth factor receptor signaling pathwayIDAbiological_process
GO:0014048Regulation of glutamate secretionIEAbiological_process
GO:0014059Regulation of dopamine secretionIEA TASbiological_process
GO:0015629Actin cytoskeletonIDAcellular_component
GO:0016234Inclusion bodyIDAcellular_component
GO:0016491Oxidoreductase activityIDAmolecular_function
GO:0019894Kinesin bindingIPImolecular_function
GO:0019904Protein domain specific bindingIEAmolecular_function
GO:0030054Cell junctionIEAcellular_component
GO:0030424AxonIDAcellular_component
GO:0030426Growth coneIDA IEAcellular_component
GO:0030544Hsp70 protein bindingIPImolecular_function
GO:0030659Cytoplasmic vesicle membraneIEAcellular_component
GO:0031092Platelet alpha granule membraneIDAcellular_component
GO:0031115Negative regulation of microtubule polymerizationIDAbiological_process
GO:0031623Receptor internalizationIDAbiological_process
GO:0031648Protein destabilizationIDAbiological_process
GO:0032026Response to magnesium ionIDAbiological_process
GO:0032410Negative regulation of transporter activityIDAbiological_process
GO:0032496Response to lipopolysaccharideIDAbiological_process
GO:0032769Negative regulation of monooxygenase activityIDAbiological_process
GO:0033138Positive regulation of peptidyl-serine phosphorylationIEA ISSbiological_process
GO:0034341Response to interferon-gammaIDAbiological_process
GO:0034599Cellular response to oxidative stressIEAbiological_process
GO:0035067Negative regulation of histone acetylationIDAbiological_process
GO:0040012Regulation of locomotionIEAbiological_process
GO:0042393Histone bindingIDA IEAmolecular_function
GO:0042416Dopamine biosynthetic processIEA TASbiological_process
GO:0042493Response to drugIEAbiological_process
GO:0042775Mitochondrial ATP synthesis coupled electron transportIEAbiological_process
GO:0042802Identical protein bindingIEA IPImolecular_function
GO:0043014Alpha-tubulin bindingIPImolecular_function
GO:0043027Cysteine-type endopeptidase inhibitor activity involved in apoptotic processIDAmolecular_function
GO:0043030Regulation of macrophage activationIEAbiological_process
GO:0043066Negative regulation of apoptotic processIMPbiological_process
GO:0043154Negative regulation of cysteine-type endopeptidase activity involved in apoptotic processIMPbiological_process
GO:0043195Terminal boutonIEAcellular_component
GO:0043205FibrilIDAcellular_component
GO:0043206Extracellular fibril organizationTASbiological_process
GO:0043274Phospholipase bindingIEAmolecular_function
GO:0043524Negative regulation of neuron apoptotic processIEAbiological_process
GO:0044344Cellular response to fibroblast growth factor stimulusIEAbiological_process
GO:0045502Dynein bindingIPImolecular_function
GO:0045807Positive regulation of endocytosisIDAbiological_process
GO:0045920Negative regulation of exocytosisIMPbiological_process
GO:0045963Negative regulation of dopamine metabolic processIEAbiological_process
GO:0047485Protein N-terminus bindingIEAmolecular_function
GO:0048148Behavioral response to cocaineIEAbiological_process
GO:0048156Tau protein bindingIDAmolecular_function
GO:0048169Regulation of long-term neuronal synaptic plasticityIEAbiological_process
GO:0048471Perinuclear region of cytoplasmIDAcellular_component
GO:0048487Beta-tubulin bindingIEAmolecular_function
GO:0048488Synaptic vesicle endocytosisIEA ISSbiological_process
GO:0050544Arachidonic acid bindingIEAmolecular_function
GO:0050808Synapse organizationIEAbiological_process
GO:0050812Regulation of acyl-CoA biosynthetic processIEAbiological_process
GO:0051219Phosphoprotein bindingIDAmolecular_function
GO:0051281Positive regulation of release of sequestered calcium ion into cytosolIDAbiological_process
GO:0051583Dopamine uptake involved in synaptic transmissionTASbiological_process
GO:0051585Negative regulation of dopamine uptake involved in synaptic transmissionIDAbiological_process
GO:0051612Negative regulation of serotonin uptakeIDAbiological_process
GO:0051622Negative regulation of norepinephrine uptakeIDAbiological_process
GO:0055074Calcium ion homeostasisIDAbiological_process
GO:0055114Oxidation-reduction processIDAbiological_process
GO:0060079Regulation of excitatory postsynaptic membrane potentialIEAbiological_process
GO:0060291Long-term synaptic potentiationIEAbiological_process
GO:0060732Positive regulation of inositol phosphate biosynthetic processIDAbiological_process
GO:0060961Phospholipase D inhibitor activityIDAmolecular_function
GO:0070495Negative regulation of thrombin receptor signaling pathwayIDAbiological_process
GO:0070555Response to interleukin-1IDAbiological_process
GO:0071280Cellular response to copper ionIDAbiological_process
GO:0071872Cellular response to epinephrine stimulusTASbiological_process
GO:0071902Positive regulation of protein serine/threonine kinase activityIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.01292833480.92347604950.28380875731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0560787720
GSE13712_SHEARDown-0.1898695018
GSE13712_STATICDown-0.0493958199
GSE19018Down-0.0427895218
GSE19899_A1Up0.6459093745
GSE19899_A2Up1.4451560370
PubMed_21979375_A1Up1.3481653846
PubMed_21979375_A2Up1.5796779173
GSE35957Down-0.0120075074
GSE36640Up0.0943196053
GSE54402Up1.1204123415
GSE9593Down-0.1045110591
GSE43922Up2.2129152434
GSE24585Down-0.4840600458
GSE37065Down-0.0327989030
GSE28863_A1Down-0.0120274124
GSE28863_A2Up0.0658406635
GSE28863_A3Up0.1178777191
GSE28863_A4Up0.0087306370
GSE48662Down-0.0119954323

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-7-5pMIMAT0000252MIRT000032qRT-PCR//Luciferase reporter assay//Western blotFunctional MTI19628698
hsa-miR-7-5pMIMAT0000252MIRT000032Immunocytochemistry//Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI20106983
hsa-miR-153-3pMIMAT0000439MIRT004733Immunocytochemistry//Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI20106983
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    • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-7-5pMIMAT00002521hsa-miR-7{Western blot}{overexpression by miRNA precursor transfection}19628698
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 4 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

25360110Interestingly, markers indicating cellular senescence or oxidative stress (SNCA, CASP3, CAT, SOD2, and TERT) were largely unchanged within the ENS
20723760These aggregates typically contain aggregation-prone pathogenic proteins, such as amyloid-beta in Alzheimer's disease and alpha-synuclein in Parkinson's disease
20723760The role of MOAG-4 in driving aggregation extends to amyloid-beta and alpha-synuclein and is evolutionarily conserved in its human orthologs SERF1A and SERF2
18369446Inclusions in the brain containing alpha-synuclein are the pathological hallmark of Parkinson's disease, but how these inclusions are formed and how this links to disease is poorly understood
18369446Quality control and vesicle-trafficking genes expressed in the ER/Golgi complex and vesicular compartments were overrepresented, indicating a specific role for these processes in alpha-synuclein inclusion formation
18369446Altogether, our data suggest a link between alpha-synuclein inclusion formation and cellular aging, likely through an endomembrane-related mechanism
18369446The processes and genes identified here present a framework for further study of the disease mechanism and provide candidate susceptibility genes and drug targets for Parkinson's disease and other alpha-synuclein related disorders
15834659Studies using proteins relevant to multiple neurodegenerative conditions (prion, alpha-synuclein, huntingtin) have demonstrated the utility of S
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