HCSGD entry for SNAI1

1. General information

Official gene symbolSNAI1
Entrez ID6615
Gene full namesnail family zinc finger 1
Other gene symbolsSLUGH2 SNA SNAH SNAIL SNAIL1 dJ710H13.1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIDA IMP ISSbiological_process
GO:0001078RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcriptionIDAmolecular_function
GO:0001649Osteoblast differentiationIEPbiological_process
GO:0001707Mesoderm formationISSbiological_process
GO:0001837Epithelial to mesenchymal transitionIDA ISSbiological_process
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDA ISScellular_component
GO:0005737CytoplasmIDA ISScellular_component
GO:0006366Transcription from RNA polymerase II promoterIDAbiological_process
GO:0010718Positive regulation of epithelial to mesenchymal transitionIMP TASbiological_process
GO:0010957Negative regulation of vitamin D biosynthetic processIDAbiological_process
GO:0016477Cell migrationIEAbiological_process
GO:0019900Kinase bindingIPImolecular_function
GO:0030335Positive regulation of cell migrationIMPbiological_process
GO:0031069Hair follicle morphogenesisIEAbiological_process
GO:0043518Negative regulation of DNA damage response, signal transduction by p53 class mediatorIMPbiological_process
GO:0043565Sequence-specific DNA bindingIEAmolecular_function
GO:0045893Positive regulation of transcription, DNA-templatedIMPbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0060021Palate developmentIEAbiological_process
GO:0060536Cartilage morphogenesisIEAbiological_process
GO:0060707Trophoblast giant cell differentiationIEAbiological_process
GO:0060806Negative regulation of cell differentiation involved in embryonic placenta developmentIEAbiological_process
GO:0060972Left/right pattern formationIEAbiological_process
GO:0061314Notch signaling involved in heart developmentISSbiological_process
GO:1902230Negative regulation of intrinsic apoptotic signaling pathway in response to DNA damageIMPbiological_process
GO:2000810Regulation of tight junction assemblyIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.08046423770.14742560690.59777002540.7422320964

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.9785087710
GSE13712_SHEARUp0.8220206861
GSE13712_STATICUp0.3589213218
GSE19018Down-0.2153278706
GSE19899_A1Up0.1219131756
GSE19899_A2Down-0.1063630125
PubMed_21979375_A1Down-0.0004646164
PubMed_21979375_A2Up0.1800125372
GSE35957Down-0.2130483257
GSE36640Up0.1564319701
GSE54402Up0.1024769068
GSE9593Down-0.9708226590
GSE43922Up0.6899834642
GSE24585Up0.6497228487
GSE37065Down-0.4234997814
GSE28863_A1Down-0.0216301358
GSE28863_A2Down-0.2616339333
GSE28863_A3Up0.6067921866
GSE28863_A4Down-0.2331830891
GSE48662Up0.4214824117

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-204-5pMIMAT0000265MIRT004651Luciferase reporter assayNon-Functional MTI20056717
hsa-miR-153-3pMIMAT0000439MIRT007098Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI23188671
hsa-miR-335-5pMIMAT0000765MIRT018418MicroarrayFunctional MTI (Weak)18185580
hsa-miR-124-3pMIMAT0000422MIRT022882MicroarrayFunctional MTI (Weak)18668037
hsa-miR-26b-5pMIMAT0000083MIRT029897MicroarrayFunctional MTI (Weak)19088304
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

20397042We have investigated the function of Snail (SNAI1) in prostate cancer cells by downregulating its expression via short (21-mer) interfering RNA (siRNA) and measuring the consequences on EMT markers, cell viability, death, cell cycle, senescence, attachment, and invasivity
20397042Of eight carcinoma cell lines, the prostate carcinoma cell lines LNCaP and PC-3 showed the highest and moderate expression of SNAI1 mRNA, respectively, as measured by quantitative RT-PCR
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