HCSGD entry for SMS
1. General information
| Official gene symbol | SMS |
|---|---|
| Entrez ID | 6611 |
| Gene full name | spermine synthase |
| Other gene symbols | MRSR SPMSY SRS SpS |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004766 | Spermidine synthase activity | TAS | molecular_function |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006555 | Methionine metabolic process | TAS | biological_process |
| GO:0006595 | Polyamine metabolic process | TAS | biological_process |
| GO:0006597 | Spermine biosynthetic process | IEA | biological_process |
| GO:0016768 | Spermine synthase activity | IEA | molecular_function |
| GO:0034641 | Cellular nitrogen compound metabolic process | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8116650355 | 0.0424935109 | 0.9999902473 | 0.3877461538 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.3625761283 |
| GSE13712_SHEAR | Up | 0.6064668723 |
| GSE13712_STATIC | Up | 0.0376734031 |
| GSE19018 | Up | 0.0196625540 |
| GSE19899_A1 | Up | 0.0551413853 |
| GSE19899_A2 | Down | -0.0569278454 |
| PubMed_21979375_A1 | Up | 0.0507985427 |
| PubMed_21979375_A2 | Down | -0.1863142923 |
| GSE35957 | Down | -0.5123376721 |
| GSE36640 | Down | -0.5111193659 |
| GSE54402 | Up | 0.1661336772 |
| GSE9593 | Up | 0.0652933523 |
| GSE43922 | Up | 0.0026424308 |
| GSE24585 | Down | -0.6151733190 |
| GSE37065 | Up | 0.1012581473 |
| GSE28863_A1 | Down | -0.2468260740 |
| GSE28863_A2 | Up | 0.1443427709 |
| GSE28863_A3 | Down | -0.3086504132 |
| GSE28863_A4 | Down | -0.1481445332 |
| GSE48662 | Down | -0.8598517112 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Spermine | DB00127 | NUTR00055 | EXPT02947 | DB02564 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-26b-5p | MIMAT0000083 | MIRT030218 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-7-1-3p | MIMAT0004553 | MIRT038683 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-324-3p | MIMAT0000762 | MIRT042888 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-149-5p | MIMAT0000450 | MIRT045576 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 5 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25972601 | However, senescent cells remain viable and display a distinct secretome (also known as senescence-associated secretory phenotype [SASP] or senescence messaging secretome, [SMS]) that, paradoxically, includes protumorigenic factors |
| 24778222 | Cellular senescence restricts the proliferative capacity of cells and is accompanied by the production of several proteins, collectively termed the "senescence-messaging secretome" (SMS) |
| 24778222 | As senescent cells accumulate in tissue, local effects of the SMS have been hypothesized to disrupt tissue regenerative capacity |
| 23360516 | This newly identified senescence phenotype, termed the senescence-associated secretory phenotype (SASP) or the senescence-messaging secretome (SMS), is induced by DNA damage that promotes the induction of cellular senescence |
| 19132009 | Recently emerging evidence points to a crucial role in oncogene-induced cellular senescence for the 'senescence-messaging secretome' or SMS, setting the stage for cross-talk between senescent cells and their environment |
| 1802784 | Main effects of growth factors (GFs) on proliferation seem to be mediated by second messengers (SMs) |
| 1802784 | A variety of feed-backs in the SM system allows to suggest that cell cycling is determined by self-oscillations of levels of the SMs and SM-dependent proteins |
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