HCSGD entry for SMO

1. General information

Official gene symbolSMO
Entrez ID6608
Gene full namesmoothened, frizzled family receptor
Other gene symbolsFZD11 Gx SMOH
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0001570VasculogenesisIBAbiological_process
GO:0001649Osteoblast differentiationIBAbiological_process
GO:0001701In utero embryonic developmentIEAbiological_process
GO:0001708Cell fate specificationIEAbiological_process
GO:0001755Neural crest cell migrationIBAbiological_process
GO:0001947Heart loopingISSbiological_process
GO:0002052Positive regulation of neuroblast proliferationIBAbiological_process
GO:0002053Positive regulation of mesenchymal cell proliferationIBAbiological_process
GO:0003007Heart morphogenesisIBAbiological_process
GO:0003140Determination of left/right asymmetry in lateral mesodermISSbiological_process
GO:0003323Type B pancreatic cell developmentIEAbiological_process
GO:0004930G-protein coupled receptor activityIEAmolecular_function
GO:0005113Patched bindingIPImolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005737CytoplasmIBAcellular_component
GO:0005794Golgi apparatusIDAcellular_component
GO:0005886Plasma membraneIBA IDAcellular_component
GO:0005901CaveolaIDAcellular_component
GO:0005929CiliumIBAcellular_component
GO:0007224Smoothened signaling pathwayIEA IEP IMPbiological_process
GO:0007228Positive regulation of hh target transcription factor activityISSbiological_process
GO:0007275Multicellular organismal developmentIEAbiological_process
GO:0007283SpermatogenesisIBAbiological_process
GO:0007368Determination of left/right symmetryIBAbiological_process
GO:0007371Ventral midline determinationISSbiological_process
GO:0007494Midgut developmentISSbiological_process
GO:0008144Drug bindingIDAmolecular_function
GO:0008406Gonad developmentIBAbiological_process
GO:0010002Cardioblast differentiationIBAbiological_process
GO:0010628Positive regulation of gene expressionISSbiological_process
GO:0010629Negative regulation of gene expressionISSbiological_process
GO:0016021Integral component of membraneIEAcellular_component
GO:0017147Wnt-protein bindingIBAmolecular_function
GO:0021508Floor plate formationIBAbiological_process
GO:0021561Facial nerve developmentIBAbiological_process
GO:0021696Cerebellar cortex morphogenesisIBAbiological_process
GO:0021794Thalamus developmentIEAbiological_process
GO:0021904Dorsal/ventral neural tube patterningIBAbiological_process
GO:0021910Smoothened signaling pathway involved in ventral spinal cord patterningIBAbiological_process
GO:0021938Smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferationIBAbiological_process
GO:0021953Central nervous system neuron differentiationIBAbiological_process
GO:0021984Adenohypophysis developmentIBAbiological_process
GO:0030165PDZ domain bindingIBAmolecular_function
GO:0030857Negative regulation of epithelial cell differentiationIEAbiological_process
GO:0031017Exocrine pancreas developmentIBAbiological_process
GO:0031069Hair follicle morphogenesisIEAbiological_process
GO:0031076Embryonic camera-type eye developmentIBAbiological_process
GO:0031102Neuron projection regenerationIBAbiological_process
GO:0032474Otolith morphogenesisIBAbiological_process
GO:0034504Protein localization to nucleusIEAbiological_process
GO:0035264Multicellular organism growthIEAbiological_process
GO:0042307Positive regulation of protein import into nucleusIEAbiological_process
GO:0042475Odontogenesis of dentin-containing toothIBAbiological_process
GO:0042693Muscle cell fate commitmentIBAbiological_process
GO:0042813Wnt-activated receptor activityIBAmolecular_function
GO:0043025Neuronal cell bodyIBAcellular_component
GO:0043066Negative regulation of apoptotic processIBAbiological_process
GO:0043231Intracellular membrane-bounded organelleIDAcellular_component
GO:0043392Negative regulation of DNA bindingISSbiological_process
GO:0045880Positive regulation of smoothened signaling pathwayIBAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0048557Embryonic digestive tract morphogenesisIBAbiological_process
GO:0048663Neuron fate commitmentIBAbiological_process
GO:0048702Embryonic neurocranium morphogenesisIBAbiological_process
GO:0048703Embryonic viscerocranium morphogenesisIBAbiological_process
GO:0048752Semicircular canal morphogenesisIBAbiological_process
GO:0048846Axon extension involved in axon guidanceIBAbiological_process
GO:0048853Forebrain morphogenesisISSbiological_process
GO:0050679Positive regulation of epithelial cell proliferationIBAbiological_process
GO:0050821Protein stabilizationIEAbiological_process
GO:0051799Negative regulation of hair follicle developmentIEAbiological_process
GO:0060070Canonical Wnt signaling pathwayIBAbiological_process
GO:0060170Ciliary membraneIEAcellular_component
GO:0060248Detection of cell density by contact stimulus involved in contact inhibitionIMPbiological_process
GO:0060413Atrial septum morphogenesisIEAbiological_process
GO:0060644Mammary gland epithelial cell differentiationIEAbiological_process
GO:0060684Epithelial-mesenchymal cell signalingIEAbiological_process
GO:0060830Ciliary receptor clustering involved in smoothened signaling pathwayIBAbiological_process
GO:0061053Somite developmentISSbiological_process
GO:0061113Pancreas morphogenesisIEAbiological_process
GO:0071397Cellular response to cholesterolISSbiological_process
GO:0072001Renal system developmentIEPbiological_process
GO:0072285Mesenchymal to epithelial transition involved in metanephric renal vesicle formationISSbiological_process
GO:0072372Primary ciliumTAScellular_component
GO:0090190Positive regulation of branching involved in ureteric bud morphogenesisISSbiological_process
GO:2000036Regulation of stem cell maintenanceIEAbiological_process
GO:2000826Regulation of heart morphogenesisISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.97971113180.00554113070.99999024730.1508253361

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1360663011
GSE13712_SHEARDown-0.7524875608
GSE13712_STATICDown-0.1394603771
GSE19018Up0.0851283301
GSE19899_A1Down-0.3526633713
GSE19899_A2Down-0.6340946220
PubMed_21979375_A1Down-1.5271120233
PubMed_21979375_A2Down-0.8639760063
GSE35957Down-0.3417192618
GSE36640Down-0.8477991433
GSE54402Down-0.5212402819
GSE9593Up0.1430729647
GSE43922Down-0.6943176363
GSE24585Down-0.3848770713
GSE37065Down-0.2810863202
GSE28863_A1Down-0.1456051653
GSE28863_A2Down-0.0758588805
GSE28863_A3Up0.2837249840
GSE28863_A4Down-0.2926927352
GSE48662Up0.7266502686

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

FluocinonideDB01047 APRD00978
VismodegibDB08828 -
SonidegibDB09143 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-125b-5pMIMAT0000423MIRT000525Luciferase reporter assay//Western blotFunctional MTI20216554
hsa-miR-125b-5pMIMAT0000423MIRT000525Luciferase reporter assay//Western blotFunctional MTI18756266
hsa-miR-326MIMAT0000756MIRT000526Luciferase reporter assay//Western blotFunctional MTI20216554
hsa-miR-326MIMAT0000756MIRT000526Luciferase reporter assay//Western blotFunctional MTI18756266
hsa-miR-326MIMAT0000756MIRT000526Western blotFunctional MTI23341351
hsa-miR-324-5pMIMAT0000761MIRT000527Luciferase reporter assay//Western blotFunctional MTI20216554
hsa-miR-324-5pMIMAT0000761MIRT000527Luciferase reporter assay//Western blotFunctional MTI18756266
hsa-miR-338-3pMIMAT0000763MIRT006455Luciferase reporter assay//qRT-PCR//Western blot//Western blot;qRT-PCRFunctional MTI21671467
hsa-miR-331-3pMIMAT0000760MIRT043390CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

20027224Interestingly, genes that showed the most significant link include those that mediate various signaling pathways implicated in colorectal tumorigenesis, such as BMP3 and BMP6 (BMP signaling), EPHA3, KIT, and FLT1 (receptor tyrosine kinases) and SMO (Hedgehog signaling)
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