HCSGD entry for SMARCA2

1. General information

Official gene symbolSMARCA2
Entrez ID6595
Gene full nameSWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
Other gene symbolsBAF190 BRM NCBRS SNF2 SNF2L2 SNF2LA SWI2 Sth1p hBRM hSNF2a
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterTASbiological_process
GO:0000790Nuclear chromatinIDAcellular_component
GO:0001105RNA polymerase II transcription coactivator activityIDAmolecular_function
GO:0003713Transcription coactivator activityTASmolecular_function
GO:0004386Helicase activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005730NucleolusIDAcellular_component
GO:0006200ATP catabolic processTASbiological_process
GO:0006338Chromatin remodelingTASbiological_process
GO:0006355Regulation of transcription, DNA-templatedIEA TASbiological_process
GO:0006357Regulation of transcription from RNA polymerase II promoterTASbiological_process
GO:0006366Transcription from RNA polymerase II promoterIDAbiological_process
GO:0007399Nervous system developmentIEAbiological_process
GO:0008094DNA-dependent ATPase activityTASmolecular_function
GO:0008285Negative regulation of cell proliferationIEAbiological_process
GO:0016514SWI/SNF complexIDAcellular_component
GO:0016818Hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydridesIEAmolecular_function
GO:0030308Negative regulation of cell growthIMPbiological_process
GO:0035887Aortic smooth muscle cell differentiationIEAbiological_process
GO:0043231Intracellular membrane-bounded organelleIDAcellular_component
GO:0044212Transcription regulatory region DNA bindingIDAmolecular_function
GO:0045111Intermediate filament cytoskeletonIDAcellular_component
GO:0045892Negative regulation of transcription, DNA-templatedIDAbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIDA IMPbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDA TASbiological_process
GO:0071564NpBAF complexIEA ISScellular_component
GO:0071565NBAF complexIEA ISScellular_component
GO:0071778WINAC complexIDAcellular_component
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.42825877440.06906253180.99999024730.4955820338

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0226185827
GSE13712_SHEARDown-0.3112904728
GSE13712_STATICDown-0.6149384996
GSE19018Up0.0368266336
GSE19899_A1Down-0.1911580226
GSE19899_A2Down-1.0444821410
PubMed_21979375_A1Down-0.8460889288
PubMed_21979375_A2Down-1.0192446785
GSE35957Up0.2649881898
GSE36640Up0.0588005429
GSE54402Down-0.6386921219
GSE9593Up0.2829235788
GSE43922Down-0.4352429039
GSE24585Up0.2671848573
GSE37065Down-0.0671096562
GSE28863_A1Up1.1203184779
GSE28863_A2Up0.4191940239
GSE28863_A3Up0.1842890262
GSE28863_A4Up0.0460088962
GSE48662Up0.0836627156

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-199a-5pMIMAT0000231MIRT006561Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI21189327
hsa-miR-199a-3pMIMAT0000232MIRT006560Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI21189327
hsa-miR-186-5pMIMAT0000456MIRT021170SequencingFunctional MTI (Weak)20371350
hsa-miR-124-3pMIMAT0000422MIRT023063Proteomics;MicroarrayFunctional MTI (Weak)18668037
hsa-miR-1MIMAT0000416MIRT023973ProteomicsFunctional MTI (Weak)18668040
hsa-miR-215-5pMIMAT0000272MIRT024676MicroarrayFunctional MTI (Weak)19074876
hsa-miR-192-5pMIMAT0000222MIRT026760MicroarrayFunctional MTI (Weak)19074876
hsa-miR-19b-3pMIMAT0000074MIRT031298SequencingFunctional MTI (Weak)20371350
hsa-miR-615-3pMIMAT0003283MIRT040280CLASHFunctional MTI (Weak)23622248
hsa-miR-423-3pMIMAT0001340MIRT042638CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

27115165Degenerative changes in RPE cells of aged SAMP8 mice, including massive vacuoles, thickened Bruch's membrane (BrM), and loss of basal infoldings were further confirmed by electron microscopy
25385658Degenerative alterations, including the disruption of the inner segment (IS)/outer segment (OS) junction and extensive vacuolation and thickness of Bruch's membrane (BrM) were observed under a a light microscope
19448667Mammalian SWI/SNF remodeling complexes incorporate either the Brahma-related gene 1 (BRG1) or Brahma (Brm) as the ATPase subunit
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