HCSGD entry for SLC22A5

1. General information

Official gene symbolSLC22A5
Entrez ID6584
Gene full namesolute carrier family 22 (organic cation/carnitine transporter), member 5
Other gene symbolsCDSP OCTN2 OCTN2VT
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0003333Amino acid transmembrane transportIDA IMPbiological_process
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005886Plasma membraneIC TAScellular_component
GO:0006814Sodium ion transportIEAbiological_process
GO:0006855Drug transmembrane transportICbiological_process
GO:0015226Carnitine transmembrane transporter activityIDA IMPmolecular_function
GO:0015238Drug transmembrane transporter activityICmolecular_function
GO:0015293Symporter activityIEAmolecular_function
GO:0015651Quaternary ammonium group transmembrane transporter activityIDAmolecular_function
GO:0015697Quaternary ammonium group transportIDAbiological_process
GO:0015879Carnitine transportIDA IMPbiological_process
GO:0015893Drug transportICbiological_process
GO:0016021Integral component of membraneIEAcellular_component
GO:0016323Basolateral plasma membraneIEAcellular_component
GO:0016324Apical plasma membraneIDAcellular_component
GO:0022857Transmembrane transporter activityIEAmolecular_function
GO:0030165PDZ domain bindingIPImolecular_function
GO:0031526Brush border membraneIDA ISScellular_component
GO:0042895Antibiotic transporter activityIEAmolecular_function
GO:0052106Quorum sensing involved in interaction with hostIMPbiological_process
GO:0055085Transmembrane transportTASbiological_process
GO:0060731Positive regulation of intestinal epithelial structure maintenanceIMPbiological_process
GO:0070715Sodium-dependent organic cation transportIDAbiological_process
GO:0072337Modified amino acid transportIDA IMPbiological_process
GO:1902603Carnitine transmembrane transportIDA IMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.13422008280.61971115460.74203041381.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1628539949
GSE13712_SHEARUp0.0282882600
GSE13712_STATICUp0.4117544329
GSE19018Up0.3686576095
GSE19899_A1Down-0.0494187915
GSE19899_A2Up0.0989793058
PubMed_21979375_A1Up0.2644074358
PubMed_21979375_A2Up0.4678845308
GSE35957Up0.1994901933
GSE36640Up0.6428243024
GSE54402Down-0.4604791191
GSE9593Up0.4338449035
GSE43922Down-0.1400308771
GSE24585Down-0.2300289697
GSE37065Up0.2126846103
GSE28863_A1Up0.1409374680
GSE28863_A2Up0.2566612361
GSE28863_A3Down-0.3051381214
GSE28863_A4Down-0.3556908914
GSE48662Up0.1616945598

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

L-CarnitineDB00583 APRD01070

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-124-3pMIMAT0000422MIRT002618MicroarrayFunctional MTI (Weak)15685193
hsa-miR-124-3pMIMAT0000422MIRT002618MicroarrayFunctional MTI (Weak)18668037
hsa-miR-148b-3pMIMAT0000759MIRT019378MicroarrayFunctional MTI (Weak)17612493
hsa-miR-9-5pMIMAT0000441MIRT021427MicroarrayFunctional MTI (Weak)17612493
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.