HCSGD entry for BMPR1B

1. General information

Official gene symbolBMPR1B
Entrez ID658
Gene full namebone morphogenetic protein receptor, type IB
Other gene symbolsALK-6 ALK6 CDw293
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001501Skeletal system developmentIMPbiological_process
GO:0001502Cartilage condensationIEA NASbiological_process
GO:0001550Ovarian cumulus expansionIEA ISSbiological_process
GO:0001654Eye developmentISSbiological_process
GO:0002062Chondrocyte differentiationIEAbiological_process
GO:0004674Protein serine/threonine kinase activityIDAmolecular_function
GO:0004675Transmembrane receptor protein serine/threonine kinase activityIMP NASmolecular_function
GO:0004702Receptor signaling protein serine/threonine kinase activityIEAmolecular_function
GO:0005024Transforming growth factor beta-activated receptor activityIEAmolecular_function
GO:0005025Transforming growth factor beta receptor activity, type IIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIDAmolecular_function
GO:0005886Plasma membraneTAScellular_component
GO:0005887Integral component of plasma membraneICcellular_component
GO:0006468Protein phosphorylationIDAbiological_process
GO:0006954Inflammatory responseIEAbiological_process
GO:0009953Dorsal/ventral pattern formationIEAbiological_process
GO:0016020MembraneIEAcellular_component
GO:0030501Positive regulation of bone mineralizationIMPbiological_process
GO:0030509BMP signaling pathwayIDA IEA NAS TASbiological_process
GO:0031290Retinal ganglion cell axon guidanceIEAbiological_process
GO:0035108Limb morphogenesisIMPbiological_process
GO:0042698Ovulation cycleISSbiological_process
GO:0043235Receptor complexTAScellular_component
GO:0045597Positive regulation of cell differentiationIMPbiological_process
GO:0045669Positive regulation of osteoblast differentiationIMPbiological_process
GO:0046332SMAD bindingIDAmolecular_function
GO:0046872Metal ion bindingIEAmolecular_function
GO:0060041Retina development in camera-type eyeIEAbiological_process
GO:1902043Positive regulation of extrinsic apoptotic signaling pathway via death domain receptorsIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.08417286580.84739355270.60990467801.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1858353084
GSE13712_SHEARDown-0.2162866942
GSE13712_STATICDown-0.0596711895
GSE19018Down-0.2094818039
GSE19899_A1Up0.0490238872
GSE19899_A2Up0.0903265439
PubMed_21979375_A1Up0.5182012307
PubMed_21979375_A2Up0.2974684950
GSE35957Down-0.1435213442
GSE36640Up0.5292537953
GSE54402Up1.0310823098
GSE9593Up0.8276994303
GSE43922Up0.1103569087
GSE24585Up0.0295202577
GSE37065Up0.7295649274
GSE28863_A1Down-0.2954763522
GSE28863_A2Down-0.0657344511
GSE28863_A3Up0.0083909933
GSE28863_A4Down-0.2237829364
GSE48662Up0.0544127492

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-125b-5pMIMAT0000423MIRT000346Luciferase reporter assayFunctional MTI19738052
hsa-let-7a-5pMIMAT0000062MIRT052538CLASHFunctional MTI (Weak)23622248
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    • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-125b-5pMIMAT00004231hsa-miR-125b19738052
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.