HCSGD entry for SLC16A1
1. General information
| Official gene symbol | SLC16A1 |
|---|---|
| Entrez ID | 6566 |
| Gene full name | solute carrier family 16, member 1 (monocarboxylic acid transporter 1) |
| Other gene symbols | HHF7 MCT MCT1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005739 | Mitochondrion | IEA | cellular_component |
| GO:0005813 | Centrosome | IDA | cellular_component |
| GO:0005886 | Plasma membrane | IDA IEA TAS | cellular_component |
| GO:0005887 | Integral component of plasma membrane | IDA ISS | cellular_component |
| GO:0006090 | Pyruvate metabolic process | TAS | biological_process |
| GO:0007596 | Blood coagulation | TAS | biological_process |
| GO:0008028 | Monocarboxylic acid transmembrane transporter activity | TAS | molecular_function |
| GO:0015130 | Mevalonate transmembrane transporter activity | TAS | molecular_function |
| GO:0015293 | Symporter activity | IEA | molecular_function |
| GO:0015355 | Secondary active monocarboxylate transmembrane transporter activity | IEA | molecular_function |
| GO:0015718 | Monocarboxylic acid transport | TAS | biological_process |
| GO:0015728 | Mevalonate transport | TAS | biological_process |
| GO:0016020 | Membrane | TAS | cellular_component |
| GO:0016021 | Integral component of membrane | IEA TAS | cellular_component |
| GO:0035873 | Lactate transmembrane transport | IEA | biological_process |
| GO:0035879 | Plasma membrane lactate transport | ISS | biological_process |
| GO:0042803 | Protein homodimerization activity | IEA | molecular_function |
| GO:0044237 | Cellular metabolic process | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0050900 | Leukocyte migration | TAS | biological_process |
| GO:0051297 | Centrosome organization | IMP | biological_process |
| GO:0055085 | Transmembrane transport | TAS | biological_process |
| GO:0071407 | Cellular response to organic cyclic compound | IEA | biological_process |
| GO:0097159 | Organic cyclic compound binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0488835948 | 0.4384634170 | 0.4870196442 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.5893631732 |
| GSE13712_SHEAR | Down | -0.0014108500 |
| GSE13712_STATIC | Up | 0.0295424008 |
| GSE19018 | Up | 0.4776719944 |
| GSE19899_A1 | Up | 0.8904586879 |
| GSE19899_A2 | Up | 0.6768595406 |
| PubMed_21979375_A1 | Up | 0.8385526700 |
| PubMed_21979375_A2 | Up | 0.2562098868 |
| GSE35957 | Down | -0.1744130178 |
| GSE36640 | Down | -0.5632401590 |
| GSE54402 | Up | 0.1041058088 |
| GSE9593 | Down | -0.3526362419 |
| GSE43922 | Up | 0.6616628081 |
| GSE24585 | Up | 0.1604407994 |
| GSE37065 | Up | 0.0307535802 |
| GSE28863_A1 | Up | 0.0633997820 |
| GSE28863_A2 | Up | 0.4544475407 |
| GSE28863_A3 | Down | -0.7221305297 |
| GSE28863_A4 | Down | -0.2327087692 |
| GSE48662 | Up | 0.2347925704 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-376a-5p | MIMAT0003386 | MIRT001745 | Luciferase reporter assay | Functional MTI | 17322061 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT002665 | Microarray//qRT-PCR | Functional MTI (Weak) | 16549876 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT002665 | Microarray | Functional MTI (Weak) | 15685193 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT002665 | Luciferase reporter assay//Western blot//Reporter assay;Western blot;qRT-PCR | Functional MTI | 19427019 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT002665 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-484 | MIMAT0002174 | MIRT016624 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-376a-3p | MIMAT0000729 | MIRT019664 | Reporter assay | Functional MTI | 17322061 |
| hsa-miR-128-3p | MIMAT0000424 | MIRT021959 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT040070 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-320a | MIMAT0000510 | MIRT044631 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-23b-3p | MIMAT0000418 | MIRT046336 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-376a-5p | MIMAT0003386 | 2 | hsa-miR-376a* | 17322061 | |||
| hsa-miR-376a-5p | MIMAT0003386 | 1 | hsa-miR-376a* | 17322061 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
