HCSGD entry for SLC12A4
1. General information
| Official gene symbol | SLC12A4 |
|---|---|
| Entrez ID | 6560 |
| Gene full name | solute carrier family 12 (potassium/chloride transporters), member 4 |
| Other gene symbols | KCC1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005765 | Lysosomal membrane | IDA | cellular_component |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0005887 | Integral component of plasma membrane | TAS | cellular_component |
| GO:0006810 | Transport | TAS | biological_process |
| GO:0006811 | Ion transport | TAS | biological_process |
| GO:0006813 | Potassium ion transport | IEA | biological_process |
| GO:0006820 | Anion transport | TAS | biological_process |
| GO:0006821 | Chloride transport | TAS | biological_process |
| GO:0006884 | Cell volume homeostasis | TAS | biological_process |
| GO:0015379 | Potassium:chloride symporter activity | IEA | molecular_function |
| GO:0015698 | Inorganic anion transport | TAS | biological_process |
| GO:0016020 | Membrane | IEA TAS | cellular_component |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0034220 | Ion transmembrane transport | TAS | biological_process |
| GO:0055085 | Transmembrane transport | IEA TAS | biological_process |
| GO:1902476 | Chloride transmembrane transport | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1308881919 | 0.9495850120 | 0.7348151205 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0333745266 |
| GSE13712_SHEAR | Up | 0.0745543532 |
| GSE13712_STATIC | Up | 0.0796066585 |
| GSE19018 | Up | 0.0017572745 |
| GSE19899_A1 | Down | -0.0206783191 |
| GSE19899_A2 | Up | 0.3162758463 |
| PubMed_21979375_A1 | Up | 0.0039961873 |
| PubMed_21979375_A2 | Up | 0.2363073952 |
| GSE35957 | Up | 0.0669811290 |
| GSE36640 | Up | 0.4020880428 |
| GSE54402 | Down | -0.1430572891 |
| GSE9593 | Up | 0.1061753461 |
| GSE43922 | Up | 0.4226687813 |
| GSE24585 | Up | 0.4042548926 |
| GSE37065 | Down | -0.0628735281 |
| GSE28863_A1 | Up | 0.0481629139 |
| GSE28863_A2 | Up | 0.1271661871 |
| GSE28863_A3 | Up | 0.0322846852 |
| GSE28863_A4 | Down | -0.0830240940 |
| GSE48662 | Up | 0.7622023788 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-30a-5p | MIMAT0000087 | MIRT005176 | pSILAC//Proteomics;Other | Functional MTI (Weak) | 18668040 |
| hsa-miR-155-5p | MIMAT0000646 | MIRT020815 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049408 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-25-3p | MIMAT0000081 | MIRT050324 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7e-5p | MIMAT0000066 | MIRT051485 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
