HCSGD entry for SLC12A3

1. General information

Official gene symbolSLC12A3
Entrez ID6559
Gene full namesolute carrier family 12 (sodium/chloride transporters), member 3
Other gene symbolsNCC NCCT TSC
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005215Transporter activityISSmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005829CytosolIEAcellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0005887Integral component of plasma membraneTAScellular_component
GO:0006810TransportTASbiological_process
GO:0006811Ion transportTASbiological_process
GO:0006814Sodium ion transportISSbiological_process
GO:0006820Anion transportTASbiological_process
GO:0006821Chloride transportTASbiological_process
GO:0015377Cation:chloride symporter activityIEAmolecular_function
GO:0015378Sodium:chloride symporter activityTASmolecular_function
GO:0015698Inorganic anion transportTASbiological_process
GO:0016020MembraneTAScellular_component
GO:0016021Integral component of membraneIEAcellular_component
GO:0016324Apical plasma membraneIDA ISScellular_component
GO:0035725Sodium ion transmembrane transportISSbiological_process
GO:0055085Transmembrane transportTASbiological_process
GO:1902476Chloride transmembrane transportTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.81499258010.57043901450.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1113307872
GSE13712_SHEARDown-0.1766871958
GSE13712_STATICDown-0.1015410438
GSE19018Down-0.0322770978
GSE19899_A1Down-0.0276214575
GSE19899_A2Down-0.0522584628
PubMed_21979375_A1Down-0.1427880012
PubMed_21979375_A2Down-0.0382034671
GSE35957Up0.0889704379
GSE36640Up0.0164360173
GSE54402Down-0.0596641667
GSE9593Down-0.0760309217
GSE43922Up0.0356394333
GSE24585Down-0.0030941130
GSE37065Up0.0137507283
GSE28863_A1Up0.0156627891
GSE28863_A2Up0.1857206634
GSE28863_A3Up0.4967209188
GSE28863_A4Down-0.0465854693
GSE48662Down-0.0562096262

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

BendroflumethiazideDB00436 APRD00666
ChlorothiazideDB00880 APRD00721
HydrochlorothiazideDB00999 APRD00092
DiazoxideDB01119 APRD00914
PolythiazideDB01324 -
QuinethazoneDB01325 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT017508MicroarrayFunctional MTI (Weak)18185580
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.