HCSGD entry for SLC11A1

1. General information

Official gene symbolSLC11A1
Entrez ID6556
Gene full namesolute carrier family 11 (proton-coupled divalent metal ion transporters), member 1
Other gene symbolsLSH NRAMP NRAMP1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000060Protein import into nucleus, translocationIEAbiological_process
GO:0001818Negative regulation of cytokine productionISSbiological_process
GO:0001819Positive regulation of cytokine productionISSbiological_process
GO:0002309T cell proliferation involved in immune responseISSbiological_process
GO:0002369T cell cytokine productionISSbiological_process
GO:0002606Positive regulation of dendritic cell antigen processing and presentationISSbiological_process
GO:0002827Positive regulation of T-helper 1 type immune responseISSbiological_process
GO:0003674Molecular_functionNDmolecular_function
GO:0005215Transporter activityIEAmolecular_function
GO:0005384Manganese ion transmembrane transporter activityISSmolecular_function
GO:0005575Cellular_componentNDcellular_component
GO:0005764LysosomeISScellular_component
GO:0005770Late endosomeISScellular_component
GO:0005886Plasma membraneIMPcellular_component
GO:0005887Integral component of plasma membraneNAScellular_component
GO:0006826Iron ion transportIMPbiological_process
GO:0006828Manganese ion transportISSbiological_process
GO:0006876Cellular cadmium ion homeostasisIGIbiological_process
GO:0006879Cellular iron ion homeostasisIMPbiological_process
GO:0006909PhagocytosisISSbiological_process
GO:0006954Inflammatory responseISSbiological_process
GO:0006955Immune responseNASbiological_process
GO:0007035Vacuolar acidificationISSbiological_process
GO:0009279Cell outer membraneIEAcellular_component
GO:0009617Response to bacteriumIDAbiological_process
GO:0010628Positive regulation of gene expressionISSbiological_process
GO:0015672Monovalent inorganic cation transportIGIbiological_process
GO:0015707Nitrite transportISSbiological_process
GO:0016020MembraneIEAcellular_component
GO:0030670Phagocytic vesicle membraneIDAcellular_component
GO:0031902Late endosome membraneTAScellular_component
GO:0032147Activation of protein kinase activityISSbiological_process
GO:0032496Response to lipopolysaccharideISSbiological_process
GO:0032623Interleukin-2 productionISSbiological_process
GO:0032632Interleukin-3 productionISSbiological_process
GO:0032729Positive regulation of interferon-gamma productionISSbiological_process
GO:0034341Response to interferon-gammaISSbiological_process
GO:0042060Wound healingISSbiological_process
GO:0042116Macrophage activationISSbiological_process
GO:0042742Defense response to bacteriumISSbiological_process
GO:0042803Protein homodimerization activityIDAmolecular_function
GO:0042832Defense response to protozoanISSbiological_process
GO:0043091L-arginine importISSbiological_process
GO:0045342MHC class II biosynthetic processISSbiological_process
GO:0045730Respiratory burstISSbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterISSbiological_process
GO:0046915Transition metal ion transmembrane transporter activityIGImolecular_function
GO:0048002Antigen processing and presentation of peptide antigenISSbiological_process
GO:0048255MRNA stabilizationISSbiological_process
GO:0050766Positive regulation of phagocytosisISSbiological_process
GO:0050829Defense response to Gram-negative bacteriumISSbiological_process
GO:0051139Metal ion:hydrogen antiporter activityIGImolecular_function
GO:0051701Interaction with hostTASbiological_process
GO:0055072Iron ion homeostasisISSbiological_process
GO:0055085Transmembrane transportTASbiological_process
GO:0060586Multicellular organismal iron ion homeostasisISSbiological_process
GO:0070574Cadmium ion transmembrane transportIGIbiological_process
GO:0070821Tertiary granule membraneIDAcellular_component
GO:0070839Divalent metal ion exportISSbiological_process
GO:0090382Phagosome maturationTASbiological_process
GO:1902600Hydrogen ion transmembrane transportIGIbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.85249247370.75007144870.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1010225327
GSE13712_SHEARUp0.0052200052
GSE13712_STATICUp0.0698406130
GSE19018Down-0.0042910857
GSE19899_A1Up0.0049034323
GSE19899_A2Up0.0598945649
PubMed_21979375_A1Down-0.1439375072
PubMed_21979375_A2Down-0.0295561802
GSE35957Up0.1049156632
GSE36640Up0.0790688234
GSE54402Down-0.0221023187
GSE9593Down-0.0220749174
GSE43922Up0.0242464604
GSE24585Down-0.0281517749
GSE37065Down-0.0415590752
GSE28863_A1Down-0.0123703634
GSE28863_A2Down-0.1362134452
GSE28863_A3Up0.3025457906
GSE28863_A4Up0.0416393037
GSE48662Up0.0293437362

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.