HCSGD entry for BMP7

1. General information

Official gene symbolBMP7
Entrez ID655
Gene full namebone morphogenetic protein 7
Other gene symbolsOP-1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001501Skeletal system developmentTASbiological_process
GO:0001503OssificationIEAbiological_process
GO:0001656Metanephros developmentIEPbiological_process
GO:0001657Ureteric bud developmentISSbiological_process
GO:0001707Mesoderm formationIEAbiological_process
GO:0001823Mesonephros developmentIEPbiological_process
GO:0001837Epithelial to mesenchymal transitionTASbiological_process
GO:0005125Cytokine activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionIEA TAScellular_component
GO:0005615Extracellular spaceIDAcellular_component
GO:0007411Axon guidanceIEAbiological_process
GO:0008083Growth factor activityIEAmolecular_function
GO:0008201Heparin bindingIEAmolecular_function
GO:0009880Embryonic pattern specificationIEAbiological_process
GO:0010664Negative regulation of striated muscle cell apoptotic processISSbiological_process
GO:0010800Positive regulation of peptidyl-threonine phosphorylationIDAbiological_process
GO:0010862Positive regulation of pathway-restricted SMAD protein phosphorylationIDA TASbiological_process
GO:0016358Dendrite developmentTASbiological_process
GO:0030198Extracellular matrix organizationTASbiological_process
GO:0030326Embryonic limb morphogenesisIEAbiological_process
GO:0030501Positive regulation of bone mineralizationIDAbiological_process
GO:0030509BMP signaling pathwayIDAbiological_process
GO:0030855Epithelial cell differentiationIEAbiological_process
GO:0031012Extracellular matrixIEAcellular_component
GO:0031988Membrane-bounded vesicleIEAcellular_component
GO:0032088Negative regulation of NF-kappaB transcription factor activityISSbiological_process
GO:0032355Response to estradiolIEAbiological_process
GO:0033280Response to vitamin DIEAbiological_process
GO:0034116Positive regulation of heterotypic cell-cell adhesionIDAbiological_process
GO:0034504Protein localization to nucleusIDAbiological_process
GO:0040007GrowthIEAbiological_process
GO:0042326Negative regulation of phosphorylationIDAbiological_process
GO:0042347Negative regulation of NF-kappaB import into nucleusISSbiological_process
GO:0042475Odontogenesis of dentin-containing toothIEAbiological_process
GO:0043065Positive regulation of apoptotic processIEAbiological_process
GO:0043401Steroid hormone mediated signaling pathwayIMPbiological_process
GO:0043407Negative regulation of MAP kinase activityIDAbiological_process
GO:0043434Response to peptide hormoneIEAbiological_process
GO:0045665Negative regulation of neuron differentiationIDAbiological_process
GO:0045666Positive regulation of neuron differentiationIEAbiological_process
GO:0045669Positive regulation of osteoblast differentiationIDAbiological_process
GO:0045746Negative regulation of Notch signaling pathwayIEAbiological_process
GO:0045786Negative regulation of cell cycleIDAbiological_process
GO:0045839Negative regulation of mitosisIDAbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedIDAbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIDAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0048596Embryonic camera-type eye morphogenesisIEAbiological_process
GO:0048754Branching morphogenesis of an epithelial tubeIEAbiological_process
GO:0048762Mesenchymal cell differentiationIDAbiological_process
GO:0048812Neuron projection morphogenesisIDAbiological_process
GO:0050768Negative regulation of neurogenesisIEAbiological_process
GO:0051216Cartilage developmentIEAbiological_process
GO:0060272Embryonic skeletal joint morphogenesisIEAbiological_process
GO:0060393Regulation of pathway-restricted SMAD protein phosphorylationIDAbiological_process
GO:0060395SMAD protein signal transductionIDAbiological_process
GO:0060445Branching involved in salivary gland morphogenesisIEAbiological_process
GO:0060485Mesenchyme developmentISSbiological_process
GO:0060548Negative regulation of cell deathIDAbiological_process
GO:0060686Negative regulation of prostatic bud formationIEAbiological_process
GO:0060687Regulation of branching involved in prostate gland morphogenesisIEAbiological_process
GO:0070487Monocyte aggregationIDAbiological_process
GO:0071456Cellular response to hypoxiaISSbiological_process
GO:0072040Negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesisIEAbiological_process
GO:0072125Negative regulation of glomerular mesangial cell proliferationIDAbiological_process
GO:0072133Metanephric mesenchyme morphogenesisIEAbiological_process
GO:0072134Nephrogenic mesenchyme morphogenesisIEAbiological_process
GO:0072136Metanephric mesenchymal cell proliferation involved in metanephros developmentIEAbiological_process
GO:1900006Positive regulation of dendrite developmentIDAbiological_process
GO:1900106Positive regulation of hyaluranon cable assemblyIDAbiological_process
GO:2000121Regulation of removal of superoxide radicalsISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.84715264620.62735478900.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0565129947
GSE13712_SHEARDown-0.1255597178
GSE13712_STATICDown-0.1472084021
GSE19018Down-0.0255696510
GSE19899_A1Up0.0395067067
GSE19899_A2Up0.1484248624
PubMed_21979375_A1Up0.2761109871
PubMed_21979375_A2Up0.0427556076
GSE35957Up0.2005918621
GSE36640Down-0.0224172160
GSE54402Up0.0904177381
GSE9593Up0.0525465720
GSE43922Up0.0556329842
GSE24585Down-0.5524460458
GSE37065Up0.0332572083
GSE28863_A1Down-0.1112157947
GSE28863_A2Down-0.1564088463
GSE28863_A3Up0.1803530963
GSE28863_A4Up0.0317358250
GSE48662Up0.0139743683

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-22-3pMIMAT0000077MIRT002000qRT-PCR//Luciferase reporter assay//Western blotFunctional MTI19011694
hsa-miR-342-3pMIMAT0000753MIRT005882Luciferase reporter assay//Northern blot//qRT-PCRFunctional MTI21172025
hsa-miR-34a-5pMIMAT0000255MIRT007204Western blotFunctional MTI23226240
hsa-miR-1MIMAT0000416MIRT023527MicroarrayFunctional MTI (Weak)18668037
hsa-let-7b-5pMIMAT0000063MIRT052250CLASHFunctional MTI (Weak)23622248
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    • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-22-3pMIMAT0000077NAhsa-miR-22{Western blot}{overexpression}19011694
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26069700The effect of osteogenic protein-1 (OP-1) or interleukin-1alpha (IL-1alpha) treatment on telomerase activity in chondrocytes was also measured to determine the response to anabolic or catabolic stimuli
26069700Chondrocytes from prepubescent horses (<15 months) were treated with OP-1 or IL-1alpha
26069700Treatment with IL-1alpha resulted in a decrease in chondrocyte telomerase activity; however, treatment with OP-1 did not change telomerase activity
19193721Here we report that the cytokine bone morphogenetic protein-7 (BMP7) induces Smad3 phosphorylation, nuclear translocation, and hTERT gene repression
19193721BMP7 induces Smad3-dependent telomerase inhibition in a time- and concentration-dependent manner in breast cancer cells
19193721Thus, our data suggest that BMP7 induces breast cancer cell aging and death by a mechanism involving inhibition of telomerase activity and telomere maintenance via BMPRII receptor- and Smad3-mediated repression of the hTERT gene
15880640Along with these changes in multipotentiality, late MSCs expressed decreased levels of the bone morphogenic protein (BMP-7) and reduced activity of alkaline phosphatase
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