HCSGD entry for SLC9A1

1. General information

Official gene symbolSLC9A1
Entrez ID6548
Gene full namesolute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
Other gene symbolsAPNH NHE-1 NHE1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001101Response to acidIDA IEAbiological_process
GO:0002026Regulation of the force of heart contractionIEAbiological_process
GO:0005515Protein bindingIPImolecular_function
GO:0005516Calmodulin bindingIEAmolecular_function
GO:0005737CytoplasmIDAcellular_component
GO:0005739MitochondrionIEAcellular_component
GO:0005783Endoplasmic reticulumIEA ISScellular_component
GO:0005789Endoplasmic reticulum membraneIEAcellular_component
GO:0005886Plasma membraneIDA TAScellular_component
GO:0005975Carbohydrate metabolic processTASbiological_process
GO:0006811Ion transportTASbiological_process
GO:0006885Regulation of pHIDA IEA TASbiological_process
GO:0010447Response to acidityIDA IEAbiological_process
GO:0014070Response to organic cyclic compoundIEAbiological_process
GO:0015299Solute:hydrogen antiporter activityTASmolecular_function
GO:0015385Sodium:hydrogen antiporter activityIDA IEA ISSmolecular_function
GO:0016021Integral component of membraneIEA TAScellular_component
GO:0016049Cell growthIEAbiological_process
GO:0016323Basolateral plasma membraneIEAcellular_component
GO:0030203Glycosaminoglycan metabolic processTASbiological_process
GO:0030212Hyaluronan metabolic processTASbiological_process
GO:0030214Hyaluronan catabolic processTASbiological_process
GO:0030307Positive regulation of cell growthIEAbiological_process
GO:0035794Positive regulation of mitochondrial membrane permeabilityIEAbiological_process
GO:0042493Response to drugIEAbiological_process
GO:0043066Negative regulation of apoptotic processIEAbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045121Membrane raftIEAcellular_component
GO:0045760Positive regulation of action potentialIEAbiological_process
GO:0048306Calcium-dependent protein bindingIDAmolecular_function
GO:0051259Protein oligomerizationISSbiological_process
GO:0051453Regulation of intracellular pHIDAbiological_process
GO:0051930Regulation of sensory perception of painIEAbiological_process
GO:0055007Cardiac muscle cell differentiationIEAbiological_process
GO:0055085Transmembrane transportTASbiological_process
GO:0070997Neuron deathIEAbiological_process
GO:0071436Sodium ion exportISSbiological_process
GO:0071468Cellular response to acidityISSbiological_process
GO:1902600Hydrogen ion transmembrane transportIDA ISS TASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00078135330.99849399720.07817765151.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.4020831454
GSE13712_SHEARUp0.5586200794
GSE13712_STATICUp0.3882018413
GSE19018Up0.4376476555
GSE19899_A1Up0.5559416390
GSE19899_A2Up1.0254707947
PubMed_21979375_A1Up0.2378670121
PubMed_21979375_A2Up1.0260187250
GSE35957Up0.2785568728
GSE36640Up0.9683338180
GSE54402Up0.1990361448
GSE9593Up0.3770174096
GSE43922Up0.8994315906
GSE24585Up0.7939782168
GSE37065Up0.1120737875
GSE28863_A1Up0.3668233784
GSE28863_A2Up1.4001631397
GSE28863_A3Down-0.1970906787
GSE28863_A4Down-0.0505804945
GSE48662Up0.2488641019

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

AmilorideDB00594 APRD00790 | EXPT00514
Homoserine LactoneDB02624 EXPT01784

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-122-5pMIMAT0000421MIRT023332MicroarrayFunctional MTI (Weak)17612493
hsa-miR-331-3pMIMAT0000760MIRT043512CLASHFunctional MTI (Weak)23622248
hsa-miR-106b-5pMIMAT0000680MIRT044326CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.