HCSGD entry for SLC6A4

1. General information

Official gene symbolSLC6A4
Entrez ID6532
Gene full namesolute carrier family 6 (neurotransmitter transporter, serotonin), member 4
Other gene symbols5-HTT 5-HTTLPR 5HTT HTT OCD1 SERT SERT1 hSERT
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001666Response to hypoxiaIEAbiological_process
GO:0005328Neurotransmitter:sodium symporter activityIEAmolecular_function
GO:0005335Serotonin:sodium symporter activityIDA IEA IMPmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005829CytosolIDAcellular_component
GO:0005886Plasma membraneIDAcellular_component
GO:0005887Integral component of plasma membraneIC IEAcellular_component
GO:0006837Serotonin transportIDAbiological_process
GO:0007584Response to nutrientIEAbiological_process
GO:0007613MemoryIEAbiological_process
GO:0007623Circadian rhythmIEAbiological_process
GO:0008504Monoamine transmembrane transporter activityIDAmolecular_function
GO:0009636Response to toxic substanceIDAbiological_process
GO:0010008Endosome membraneIEAcellular_component
GO:0010628Positive regulation of gene expressionIEAbiological_process
GO:0012505Endomembrane systemIDAcellular_component
GO:0015222Serotonin transmembrane transporter activityIDA IMPmolecular_function
GO:0015672Monovalent inorganic cation transportIDA IMPbiological_process
GO:0015844Monoamine transportIDAbiological_process
GO:0016021Integral component of membraneIEAcellular_component
GO:0017022Myosin bindingIEAmolecular_function
GO:0017075Syntaxin-1 bindingIEAmolecular_function
GO:0017137Rab GTPase bindingIPImolecular_function
GO:0019811Cocaine bindingIEAmolecular_function
GO:0021794Thalamus developmentIMPbiological_process
GO:0021941Negative regulation of cerebellar granule cell precursor proliferationIEAbiological_process
GO:0030001Metal ion transportIDA IMPbiological_process
GO:0032227Negative regulation of synaptic transmission, dopaminergicIEAbiological_process
GO:0032355Response to estradiolIEAbiological_process
GO:0034220Ion transmembrane transportIDA IMPbiological_process
GO:0035176Social behaviorIEA ISSbiological_process
GO:0035725Sodium ion transmembrane transportIDA IMPbiological_process
GO:0042310VasoconstrictionIEAbiological_process
GO:0042493Response to drugIEAbiological_process
GO:0042713Sperm ejaculationIEAbiological_process
GO:0042803Protein homodimerization activityIEAmolecular_function
GO:0043005Neuron projectionIEAcellular_component
GO:0045121Membrane raftIDA IEAcellular_component
GO:0045665Negative regulation of neuron differentiationIEAbiological_process
GO:0045787Positive regulation of cell cycleIEAbiological_process
GO:0046621Negative regulation of organ growthIEA ISSbiological_process
GO:0048854Brain morphogenesisIEA ISSbiological_process
GO:0050998Nitric-oxide synthase bindingIEAmolecular_function
GO:0051015Actin filament bindingIEA ISSmolecular_function
GO:0051259Protein oligomerizationISSbiological_process
GO:0051260Protein homooligomerizationIEAbiological_process
GO:0051610Serotonin uptakeIDA IEAbiological_process
GO:0055085Transmembrane transportIDA IMPbiological_process
GO:0071300Cellular response to retinoic acidIEAbiological_process
GO:0071321Cellular response to cGMPIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.43660041030.89526299910.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0288186776
GSE13712_SHEARUp0.0799036491
GSE13712_STATICUp0.0670488972
GSE19018Down-0.0511654920
GSE19899_A1Up0.0516862208
GSE19899_A2Up0.3863235567
PubMed_21979375_A1Up0.1885907374
PubMed_21979375_A2Up0.1546966127
GSE35957Up0.6510141395
GSE36640Up0.1762092072
GSE54402Up0.1737192145
GSE9593Up0.0626993152
GSE43922Up0.0249586181
GSE24585Up0.1344240073
GSE37065Down-0.0398447246
GSE28863_A1Up0.0113984018
GSE28863_A2Down-0.2768127063
GSE28863_A3Down-0.1455774419
GSE28863_A4Down-0.0891291352
GSE48662Down-0.0352839327

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT018862MicroarrayFunctional MTI (Weak)18185580
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.