HCSGD entry for SLC6A3
1. General information
| Official gene symbol | SLC6A3 |
|---|---|
| Entrez ID | 6531 |
| Gene full name | solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 |
| Other gene symbols | DAT DAT1 PKDYS |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0002020 | Protease binding | IEA | molecular_function |
| GO:0005102 | Receptor binding | IEA | molecular_function |
| GO:0005329 | Dopamine transmembrane transporter activity | TAS | molecular_function |
| GO:0005330 | Dopamine:sodium symporter activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005737 | Cytoplasm | TAS | cellular_component |
| GO:0005886 | Plasma membrane | IDA IEA TAS | cellular_component |
| GO:0005887 | Integral component of plasma membrane | IEA | cellular_component |
| GO:0006810 | Transport | TAS | biological_process |
| GO:0007268 | Synaptic transmission | TAS | biological_process |
| GO:0007568 | Aging | IEA | biological_process |
| GO:0007595 | Lactation | IEA | biological_process |
| GO:0007608 | Sensory perception of smell | IEA | biological_process |
| GO:0007626 | Locomotory behavior | IEA | biological_process |
| GO:0008144 | Drug binding | IEA | molecular_function |
| GO:0008219 | Cell death | IEA | biological_process |
| GO:0008504 | Monoamine transmembrane transporter activity | IDA | molecular_function |
| GO:0010039 | Response to iron ion | IEA | biological_process |
| GO:0015844 | Monoamine transport | IDA | biological_process |
| GO:0015872 | Dopamine transport | IEA | biological_process |
| GO:0016021 | Integral component of membrane | IEA TAS | cellular_component |
| GO:0021984 | Adenohypophysis development | IEA | biological_process |
| GO:0030424 | Axon | IDA IEA | cellular_component |
| GO:0032403 | Protein complex binding | IEA | molecular_function |
| GO:0034220 | Ion transmembrane transport | TAS | biological_process |
| GO:0035094 | Response to nicotine | IEA | biological_process |
| GO:0035240 | Dopamine binding | IEA | molecular_function |
| GO:0040018 | Positive regulation of multicellular organism growth | IEA | biological_process |
| GO:0042053 | Regulation of dopamine metabolic process | IEA | biological_process |
| GO:0042136 | Neurotransmitter biosynthetic process | TAS | biological_process |
| GO:0042220 | Response to cocaine | IEA | biological_process |
| GO:0042416 | Dopamine biosynthetic process | IEA | biological_process |
| GO:0042420 | Dopamine catabolic process | IEA | biological_process |
| GO:0042493 | Response to drug | IEA | biological_process |
| GO:0043025 | Neuronal cell body | IDA | cellular_component |
| GO:0045471 | Response to ethanol | IEA | biological_process |
| GO:0047485 | Protein N-terminus binding | IEA | molecular_function |
| GO:0051591 | Response to cAMP | IEA | biological_process |
| GO:0055085 | Transmembrane transport | TAS | biological_process |
| GO:0060134 | Prepulse inhibition | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5143706622 | 0.7561569013 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0698872479 |
| GSE13712_SHEAR | Down | -0.5169676922 |
| GSE13712_STATIC | Up | 0.0038532402 |
| GSE19018 | Down | -0.1116225699 |
| GSE19899_A1 | Down | -0.2017066575 |
| GSE19899_A2 | Up | 0.1854516141 |
| PubMed_21979375_A1 | Up | 0.2408542139 |
| PubMed_21979375_A2 | Down | -0.0369895566 |
| GSE35957 | Up | 0.3667856612 |
| GSE36640 | Down | -0.0522384989 |
| GSE54402 | Down | -0.0181375164 |
| GSE9593 | Up | 0.2926036061 |
| GSE43922 | Up | 0.0596233527 |
| GSE24585 | Up | 0.0760765031 |
| GSE37065 | Down | -0.1028620838 |
| GSE28863_A1 | Down | -0.0676615858 |
| GSE28863_A2 | Up | 0.1584529689 |
| GSE28863_A3 | Up | 0.3391676832 |
| GSE28863_A4 | Up | 0.1022573576 |
| GSE48662 | Up | 0.0575183002 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 15095788 | In the literature, two lines of investigation may be recognized: one based on the hypothesis of the presence of an oxidative environment responsible for red cell oxidative damage in Alzheimer's disease (AD), Alzheimer's dementia type (DAT) and Parkinson' disease (PD); the other one based on the identification of structural and/or functional abnormalities in red cell membrane band 3 and/or in red cell membrane lipid composition in "neuroacanthocytosis" |
| 15095788 | In AD, DAT and PD patients, an increased red cell membrane lipid peroxidation suggests an increase red cell oxidative damages and precocious red cell aging |
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