HCSGD entry for SLC2A4
1. General information
| Official gene symbol | SLC2A4 |
|---|---|
| Entrez ID | 6517 |
| Gene full name | solute carrier family 2 (facilitated glucose transporter), member 4 |
| Other gene symbols | GLUT4 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005355 | Glucose transmembrane transporter activity | IEA TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005771 | Multivesicular body | IEA | cellular_component |
| GO:0005886 | Plasma membrane | IDA TAS | cellular_component |
| GO:0005887 | Integral component of plasma membrane | IEA | cellular_component |
| GO:0005905 | Coated pit | IEA | cellular_component |
| GO:0005975 | Carbohydrate metabolic process | TAS | biological_process |
| GO:0008645 | Hexose transport | TAS | biological_process |
| GO:0009897 | External side of plasma membrane | IDA | cellular_component |
| GO:0010021 | Amylopectin biosynthetic process | IEA | biological_process |
| GO:0012505 | Endomembrane system | ISS | cellular_component |
| GO:0012506 | Vesicle membrane | IDA | cellular_component |
| GO:0015758 | Glucose transport | TAS | biological_process |
| GO:0016020 | Membrane | TAS | cellular_component |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0030136 | Clathrin-coated vesicle | IDA | cellular_component |
| GO:0030140 | Trans-Golgi network transport vesicle | IEA | cellular_component |
| GO:0032593 | Insulin-responsive compartment | IDA ISS | cellular_component |
| GO:0032869 | Cellular response to insulin stimulus | IDA | biological_process |
| GO:0034219 | Carbohydrate transmembrane transport | TAS | biological_process |
| GO:0035428 | Hexose transmembrane transport | TAS | biological_process |
| GO:0042383 | Sarcolemma | IEA | cellular_component |
| GO:0042593 | Glucose homeostasis | IDA | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0045471 | Response to ethanol | IEA | biological_process |
| GO:0046323 | Glucose import | NAS | biological_process |
| GO:0048471 | Perinuclear region of cytoplasm | IDA | cellular_component |
| GO:0050873 | Brown fat cell differentiation | IEA | biological_process |
| GO:0055056 | D-glucose transmembrane transporter activity | IEA | molecular_function |
| GO:0055085 | Transmembrane transport | TAS | biological_process |
| GO:0070062 | Extracellular vesicular exosome | IEA | cellular_component |
| GO:0071470 | Cellular response to osmotic stress | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.6368528589 | 0.7530949584 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1814822918 |
| GSE13712_SHEAR | Up | 0.1607120293 |
| GSE13712_STATIC | Down | -0.0863504751 |
| GSE19018 | Down | -0.0450810140 |
| GSE19899_A1 | Down | -0.1977551690 |
| GSE19899_A2 | Up | 0.0131368417 |
| PubMed_21979375_A1 | Down | -0.1336581209 |
| PubMed_21979375_A2 | Down | -0.0122699553 |
| GSE35957 | Up | 0.0751186919 |
| GSE36640 | Up | 0.1721858836 |
| GSE54402 | Up | 0.0531476262 |
| GSE9593 | Up | 0.0727236183 |
| GSE43922 | Up | 0.1131303771 |
| GSE24585 | Up | 0.0390703954 |
| GSE37065 | Down | -0.0647359203 |
| GSE28863_A1 | Down | -0.1878452919 |
| GSE28863_A2 | Down | -0.1901423193 |
| GSE28863_A3 | Up | 0.3669735226 |
| GSE28863_A4 | Up | 0.1195434741 |
| GSE48662 | Down | -0.0661070719 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-223-3p | MIMAT0000280 | MIRT006559 | Flow//Immunoblot//Immunofluorescence//Immunohistochemistry//Immunoprecipitaion//In situ hybridization//Luciferase reporter assay//Northern blot//qRT-PCR | Functional MTI | 20080987 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT019111 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-92a-1-5p | MIMAT0004507 | MIRT038921 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25263463 | GLUT2 and GLUT4 expressions were studied in HepG2 cells and human liver tissue |
| 25263463 | Further, GLUT2 and GLUT4 expressions were studied in three independent chronic liver disease cohorts |
| 25263463 | Increased GLUT4 and decreased GLUT2 expressions were evident in senescent cells, human cirrhotic liver tissue and publically available liver disease datasets |
| 19526322 | The expression of the GLUT4 and IRS-1 genes peaked during differentiation and then decreased in aged cells |
| 19526322 | LPS decreased the mRNA levels of C/EBPalpha and PPARgamma at all time points, as well as those of GLUT4, IRS-1 and adiponectin |
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