HCSGD entry for PINK1
1. General information
| Official gene symbol | PINK1 |
|---|---|
| Entrez ID | 65018 |
| Gene full name | PTEN induced putative kinase 1 |
| Other gene symbols | BRPK PARK6 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000287 | Magnesium ion binding | IDA | molecular_function |
| GO:0000422 | Mitochondrion degradation | IMP | biological_process |
| GO:0004674 | Protein serine/threonine kinase activity | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IDA | molecular_function |
| GO:0005739 | Mitochondrion | IDA | cellular_component |
| GO:0005741 | Mitochondrial outer membrane | IEA | cellular_component |
| GO:0005743 | Mitochondrial inner membrane | IEA | cellular_component |
| GO:0005829 | Cytosol | IDA | cellular_component |
| GO:0006468 | Protein phosphorylation | IDA | biological_process |
| GO:0006950 | Response to stress | IDA | biological_process |
| GO:0008219 | Cell death | IEA | biological_process |
| GO:0010857 | Calcium-dependent protein kinase activity | IDA | molecular_function |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0016301 | Kinase activity | IDA | molecular_function |
| GO:0018105 | Peptidyl-serine phosphorylation | IDA | biological_process |
| GO:0031396 | Regulation of protein ubiquitination | IDA | biological_process |
| GO:0031625 | Ubiquitin protein ligase binding | IPI | molecular_function |
| GO:0032226 | Positive regulation of synaptic transmission, dopaminergic | IEA | biological_process |
| GO:0033603 | Positive regulation of dopamine secretion | IEA | biological_process |
| GO:0035556 | Intracellular signal transduction | IDA | biological_process |
| GO:0043123 | Positive regulation of I-kappaB kinase/NF-kappaB signaling | IDA | biological_process |
| GO:0043254 | Regulation of protein complex assembly | IDA | biological_process |
| GO:0043524 | Negative regulation of neuron apoptotic process | IEA | biological_process |
| GO:0055131 | C3HC4-type RING finger domain binding | IPI | molecular_function |
| GO:0090200 | Positive regulation of release of cytochrome c from mitochondria | IMP | biological_process |
| GO:0097237 | Cellular response to toxic substance | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0118349037 | 0.8762791421 | 0.2729114410 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1586900649 |
| GSE13712_SHEAR | Down | -0.1590162322 |
| GSE13712_STATIC | Down | -0.4673789197 |
| GSE19018 | Up | 1.1534503812 |
| GSE19899_A1 | Up | 0.1247654021 |
| GSE19899_A2 | Up | 0.7760055190 |
| PubMed_21979375_A1 | Down | -0.0583586906 |
| PubMed_21979375_A2 | Up | 0.8618177252 |
| GSE35957 | Up | 0.7982920992 |
| GSE36640 | Up | 1.3938524744 |
| GSE54402 | Up | 0.1782466155 |
| GSE9593 | Up | 0.8132022718 |
| GSE43922 | Up | 0.0046986253 |
| GSE24585 | Up | 0.1627826999 |
| GSE37065 | Down | -0.2017779747 |
| GSE28863_A1 | Up | 0.0600497965 |
| GSE28863_A2 | Up | 0.3730527196 |
| GSE28863_A3 | Up | 0.0266580216 |
| GSE28863_A4 | Down | -0.4519730924 |
| GSE48662 | Up | 0.3651327527 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25714760 | Mitophagy may play a pivotal role for removal of CS-induced damaged mitochondria, and the PINK1 (PTEN-induced putative kinase 1)-PARK2 pathway has been proposed as a crucial mechanism for mitophagic degradation |
| 25714760 | To elucidate the involvement of PINK1 and PARK2 in mitophagy, knockdown and overexpression experiments were performed |
| 25714760 | PINK1 and PARK2 protein levels in lungs from patients were evaluated by means of lung homogenate and immunohistochemistry |
| 25714760 | CSE-induced mitophagy was inhibited by PINK1 and PARK2 knockdown, resulting in enhanced mitochondrial ROS production and cellular senescence in HBEC |
| 20179104 | Downregulation of PINK1 or overexpression of a PINK1 mutant (G309D) increased the sensitivity against ROS in young cells |
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