HCSGD entry for SKI
1. General information
| Official gene symbol | SKI |
|---|---|
| Entrez ID | 6497 |
| Gene full name | v-ski sarcoma viral oncogene homolog (avian) |
| Other gene symbols | SGS SKV |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | IDA IMP TAS | biological_process |
| GO:0000166 | Nucleotide binding | IEA | molecular_function |
| GO:0001843 | Neural tube closure | ISS | biological_process |
| GO:0002089 | Lens morphogenesis in camera-type eye | ISS | biological_process |
| GO:0003682 | Chromatin binding | IEA | molecular_function |
| GO:0003714 | Transcription corepressor activity | IDA IMP | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005667 | Transcription factor complex | ISS | cellular_component |
| GO:0005737 | Cytoplasm | IBA ISS | cellular_component |
| GO:0005813 | Centrosome | IDA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | ISS TAS | biological_process |
| GO:0006367 | Transcription initiation from RNA polymerase II promoter | TAS | biological_process |
| GO:0007179 | Transforming growth factor beta receptor signaling pathway | NAS TAS | biological_process |
| GO:0008270 | Zinc ion binding | IDA | molecular_function |
| GO:0008283 | Cell proliferation | NAS | biological_process |
| GO:0008285 | Negative regulation of cell proliferation | IDA | biological_process |
| GO:0009948 | Anterior/posterior axis specification | ISS | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0010626 | Negative regulation of Schwann cell proliferation | IGI | biological_process |
| GO:0014902 | Myotube differentiation | IDA | biological_process |
| GO:0016604 | Nuclear body | IDA | cellular_component |
| GO:0016605 | PML body | IDA | cellular_component |
| GO:0017053 | Transcriptional repressor complex | ISS | cellular_component |
| GO:0019901 | Protein kinase binding | IPI | molecular_function |
| GO:0019904 | Protein domain specific binding | IPI | molecular_function |
| GO:0021772 | Olfactory bulb development | ISS | biological_process |
| GO:0022011 | Myelination in peripheral nervous system | ISS | biological_process |
| GO:0030177 | Positive regulation of Wnt signaling pathway | NAS | biological_process |
| GO:0030326 | Embryonic limb morphogenesis | ISS | biological_process |
| GO:0030509 | BMP signaling pathway | TAS | biological_process |
| GO:0030512 | Negative regulation of transforming growth factor beta receptor signaling pathway | IDA IGI IMP | biological_process |
| GO:0030514 | Negative regulation of BMP signaling pathway | IDA IMP | biological_process |
| GO:0031625 | Ubiquitin protein ligase binding | IPI | molecular_function |
| GO:0032926 | Negative regulation of activin receptor signaling pathway | IDA | biological_process |
| GO:0035019 | Somatic stem cell maintenance | ISS | biological_process |
| GO:0042981 | Regulation of apoptotic process | IBA ISS | biological_process |
| GO:0043010 | Camera-type eye development | ISS | biological_process |
| GO:0043086 | Negative regulation of catalytic activity | ISS | biological_process |
| GO:0043234 | Protein complex | IDA | cellular_component |
| GO:0043388 | Positive regulation of DNA binding | IDA | biological_process |
| GO:0043585 | Nose morphogenesis | ISS | biological_process |
| GO:0045668 | Negative regulation of osteoblast differentiation | IDA | biological_process |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | ISS | biological_process |
| GO:0046332 | SMAD binding | IPI | molecular_function |
| GO:0046811 | Histone deacetylase inhibitor activity | ISS | molecular_function |
| GO:0048147 | Negative regulation of fibroblast proliferation | ISS | biological_process |
| GO:0048593 | Camera-type eye morphogenesis | ISS | biological_process |
| GO:0048741 | Skeletal muscle fiber development | ISS | biological_process |
| GO:0048870 | Cell motility | NAS | biological_process |
| GO:0050790 | Regulation of catalytic activity | ISS | biological_process |
| GO:0060021 | Palate development | ISS | biological_process |
| GO:0060041 | Retina development in camera-type eye | ISS | biological_process |
| GO:0060325 | Face morphogenesis | ISS | biological_process |
| GO:0060349 | Bone morphogenesis | ISS | biological_process |
| GO:0060395 | SMAD protein signal transduction | IDA | biological_process |
| GO:0070207 | Protein homotrimerization | IDA | biological_process |
| GO:0070491 | Repressing transcription factor binding | IPI | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.2510047453 | 0.6068709851 | 0.9409907278 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.3870951813 |
| GSE13712_SHEAR | Up | 0.0129913916 |
| GSE13712_STATIC | Up | 0.1573877265 |
| GSE19018 | Down | -0.1564277236 |
| GSE19899_A1 | Up | 0.0502124327 |
| GSE19899_A2 | Up | 0.4068705674 |
| PubMed_21979375_A1 | Down | -0.1974018656 |
| PubMed_21979375_A2 | Up | 0.6625270027 |
| GSE35957 | Up | 0.0386780160 |
| GSE36640 | Up | 0.1262725873 |
| GSE54402 | Up | 0.0550597970 |
| GSE9593 | Down | -0.0653878382 |
| GSE43922 | Down | -0.0137624687 |
| GSE24585 | Down | -0.0591021402 |
| GSE37065 | Down | -0.1390146863 |
| GSE28863_A1 | Up | 0.1956822667 |
| GSE28863_A2 | Up | 0.2496198562 |
| GSE28863_A3 | Up | 0.2667367218 |
| GSE28863_A4 | Down | -0.1347579769 |
| GSE48662 | Up | 0.6285480797 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-195-5p | MIMAT0000461 | MIRT004390 | Microarray//Northern blot | Functional MTI (Weak) | 16331254 |
| hsa-miR-155-5p | MIMAT0000646 | MIRT005885 | Immunohistochemistry//Luciferase reporter assay//Northern blot//qRT-PCR//Western blot | Functional MTI | 21062812 |
| hsa-miR-155-5p | MIMAT0000646 | MIRT005885 | Luciferase reporter assay | Functional MTI | 21466664 |
| hsa-miR-590-3p | MIMAT0004801 | MIRT016163 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-340-5p | MIMAT0004692 | MIRT019622 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-99a-5p | MIMAT0000097 | MIRT027396 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-744-5p | MIMAT0004945 | MIRT037455 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92b-3p | MIMAT0003218 | MIRT040552 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-484 | MIMAT0002174 | MIRT041820 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-149-5p | MIMAT0000450 | MIRT045579 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-221-3p | MIMAT0000278 | MIRT046951 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-196a-5p | MIMAT0000226 | MIRT048269 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049101 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT052009 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
