HCSGD entry for SIX1

1. General information

Official gene symbolSIX1
Entrez ID6495
Gene full nameSIX homeobox 1
Other gene symbolsBOS3 DFNA23 TIP39
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0001657Ureteric bud developmentISSbiological_process
GO:0001658Branching involved in ureteric bud morphogenesisISSbiological_process
GO:0001759Organ inductionISSbiological_process
GO:0001822Kidney developmentISSbiological_process
GO:0003151Outflow tract morphogenesisIEAbiological_process
GO:0003677DNA bindingIDAmolecular_function
GO:0003682Chromatin bindingIEAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIDA ISSmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005667Transcription factor complexISScellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005737CytoplasmIEAcellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006355Regulation of transcription, DNA-templatedISSbiological_process
GO:0006915Apoptotic processIEAbiological_process
GO:0007389Pattern specification processISSbiological_process
GO:0007519Skeletal muscle tissue developmentISSbiological_process
GO:0007605Sensory perception of soundIEAbiological_process
GO:0008582Regulation of synaptic growth at neuromuscular junctionIEAbiological_process
GO:0021610Facial nerve morphogenesisIEAbiological_process
GO:0030855Epithelial cell differentiationISSbiological_process
GO:0030878Thyroid gland developmentISSbiological_process
GO:0032880Regulation of protein localizationIEAbiological_process
GO:0034504Protein localization to nucleusIDAbiological_process
GO:0035909Aorta morphogenesisIEAbiological_process
GO:0042472Inner ear morphogenesisISSbiological_process
GO:0042474Middle ear morphogenesisIEAbiological_process
GO:0043524Negative regulation of neuron apoptotic processISSbiological_process
GO:0043565Sequence-specific DNA bindingIDAmolecular_function
GO:0044212Transcription regulatory region DNA bindingIDAmolecular_function
GO:0045664Regulation of neuron differentiationISSbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedISSbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0048538Thymus developmentISSbiological_process
GO:0048665Neuron fate specificationIEAbiological_process
GO:0048699Generation of neuronsISSbiological_process
GO:0048701Embryonic cranial skeleton morphogenesisISSbiological_process
GO:0048704Embryonic skeletal system morphogenesisISSbiological_process
GO:0048839Inner ear developmentISSbiological_process
GO:0051451Myoblast migrationISSbiological_process
GO:0060037Pharyngeal system developmentIEAbiological_process
GO:0071599Otic vesicle developmentIEAbiological_process
GO:0072075Metanephric mesenchyme developmentISSbiological_process
GO:0072095Regulation of branch elongation involved in ureteric bud branchingISSbiological_process
GO:0072107Positive regulation of ureteric bud formationISSbiological_process
GO:0072172Mesonephric tubule formationISSbiological_process
GO:0072193Ureter smooth muscle cell differentiationIEAbiological_process
GO:0072513Positive regulation of secondary heart field cardioblast proliferationIEAbiological_process
GO:0090103Cochlea morphogenesisIEAbiological_process
GO:0090190Positive regulation of branching involved in ureteric bud morphogenesisISSbiological_process
GO:0090191Negative regulation of branching involved in ureteric bud morphogenesisIEAbiological_process
GO:2000729Positive regulation of mesenchymal cell proliferation involved in ureter developmentIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.97790109800.00176011930.99999024730.0801524221

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0900286813
GSE13712_SHEARDown-0.0245094057
GSE13712_STATICDown-0.0411824069
GSE19018Up0.2480035790
GSE19899_A1Down-1.3879933348
GSE19899_A2Down-1.3929431640
PubMed_21979375_A1Down-1.4171925935
PubMed_21979375_A2Down-1.6675237823
GSE35957Down-0.3018150093
GSE36640Down-1.7753832701
GSE54402Down-1.5667394253
GSE9593Down-0.6064702904
GSE43922Down-1.6183320705
GSE24585Down-0.6727186136
GSE37065Down-0.1402019126
GSE28863_A1Up0.0410881765
GSE28863_A2Down-0.0044358208
GSE28863_A3Up0.2581519856
GSE28863_A4Up0.0448382504
GSE48662Up0.3849112253

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-185-5pMIMAT0000455MIRT005550Luciferase reporter assay//qRT-PCR//Quantitative proteomic approach//Western blotFunctional MTI20603620
hsa-miR-193b-3pMIMAT0002819MIRT016461MicroarrayFunctional MTI (Weak)20304954
hsa-miR-26b-5pMIMAT0000083MIRT029669MicroarrayFunctional MTI (Weak)19088304
hsa-miR-324-3pMIMAT0000762MIRT042949CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26500063Here we show that SIX1, a member of the SIX family of homeobox transcriptional factors, is a novel repressor of senescence
26500063Our data show that SIX1 is specifically downregulated in fibroblasts upon oncogenic stress and other pro-senescence stimuli, as well as in senescent skin premalignant lesions
26500063Silencing of SIX1 in human fibroblasts suffices to trigger senescence, which is mediated by p16INK4A and lacks a canonical senescence-associated secretory phenotype
26500063Interestingly, SIX1-associated senescence is further characterized by the expression of a set of development and differentiation-related genes that significantly overlap with genes associated with SIX1 in organogenesis or human tumors, and show coincident regulation in oncogene-induced senescence
26500063Mechanistically, we show that gene regulation by SIX1 during senescence is mediated, at least in part, by cooperation with Polycomb repressive complexes
26500063In summary, our results identify SIX1, a key development regulator altered in human tumors, as a critical repressor of cellular senescence, providing a novel connection between senescence, differentiation and tumorigenesis
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