HCSGD entry for SIPA1

1. General information

Official gene symbolSIPA1
Entrez ID6494
Gene full namesignal-induced proliferation-associated 1
Other gene symbolsSPA1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005096GTPase activator activityIEA TASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusICcellular_component
GO:0005829CytosolTAScellular_component
GO:0007010Cytoskeleton organizationNASbiological_process
GO:0007162Negative regulation of cell adhesionNASbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0008022Protein C-terminus bindingIEAmolecular_function
GO:0008283Cell proliferationTASbiological_process
GO:0012505Endomembrane systemIEAcellular_component
GO:0016020MembraneIEAcellular_component
GO:0030133Transport vesicleIEAcellular_component
GO:0030308Negative regulation of cell growthNASbiological_process
GO:0032320Positive regulation of Ras GTPase activityNASbiological_process
GO:0032854Positive regulation of Rap GTPase activityNASbiological_process
GO:0035556Intracellular signal transductionNASbiological_process
GO:0042631Cellular response to water deprivationIEAbiological_process
GO:0043085Positive regulation of catalytic activityNASbiological_process
GO:0043234Protein complexIEAcellular_component
GO:0043547Positive regulation of GTPase activityNASbiological_process
GO:0045786Negative regulation of cell cycleNASbiological_process
GO:0046582Rap GTPase activator activityNASmolecular_function
GO:0048471Perinuclear region of cytoplasmIEAcellular_component
GO:0050790Regulation of catalytic activityNASbiological_process
GO:0051056Regulation of small GTPase mediated signal transductionIEAbiological_process
GO:0051726Regulation of cell cycleIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.34983658300.81535730790.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0199028910
GSE13712_SHEARUp0.3088890717
GSE13712_STATICDown-0.0839989957
GSE19018Up0.2240892602
GSE19899_A1Down-0.0329753298
GSE19899_A2Up0.1291530733
PubMed_21979375_A1Down-0.0581070064
PubMed_21979375_A2Up0.3898491727
GSE35957Down-0.4017949401
GSE36640Up0.0868425425
GSE54402Up0.2551507554
GSE9593Down-0.3842821089
GSE43922--
GSE24585--
GSE37065--
GSE28863_A1Up0.0461309758
GSE28863_A2Up0.3671592188
GSE28863_A3Up0.1123517186
GSE28863_A4Down-0.0380857485
GSE48662Down-0.1580924856

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-26b-5pMIMAT0000083MIRT030296MicroarrayFunctional MTI (Weak)19088304
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.