HCSGD entry for BCL11B
1. General information
| Official gene symbol | BCL11B |
|---|---|
| Entrez ID | 64919 |
| Gene full name | B-cell CLL/lymphoma 11B (zinc finger protein) |
| Other gene symbols | ATL1-alpha ATL1-beta ATL1-delta ATL1-gamma CTIP-2 CTIP2 RIT1 ZNF856B hRIT1-alpha |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000978 | RNA polymerase II core promoter proximal region sequence-specific DNA binding | IEA | molecular_function |
| GO:0001077 | RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription | IEA | molecular_function |
| GO:0003334 | Keratinocyte development | IEA | biological_process |
| GO:0003382 | Epithelial cell morphogenesis | IEA | biological_process |
| GO:0003676 | Nucleic acid binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0008285 | Negative regulation of cell proliferation | IEA | biological_process |
| GO:0010837 | Regulation of keratinocyte proliferation | IEA | biological_process |
| GO:0019216 | Regulation of lipid metabolic process | IEA | biological_process |
| GO:0021773 | Striatal medium spiny neuron differentiation | IEA | biological_process |
| GO:0031077 | Post-embryonic camera-type eye development | IEA | biological_process |
| GO:0033077 | T cell differentiation in thymus | IEA | biological_process |
| GO:0033153 | T cell receptor V(D)J recombination | IEA | biological_process |
| GO:0042475 | Odontogenesis of dentin-containing tooth | IEA | biological_process |
| GO:0043066 | Negative regulation of apoptotic process | IEA | biological_process |
| GO:0043368 | Positive T cell selection | IEA | biological_process |
| GO:0045664 | Regulation of neuron differentiation | IEA | biological_process |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IMP | biological_process |
| GO:0046632 | Alpha-beta T cell differentiation | IEA | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0048538 | Thymus development | IEA | biological_process |
| GO:0071678 | Olfactory bulb axon guidance | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5567608450 | 0.8532802743 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0262550065 |
| GSE13712_SHEAR | Down | -0.0968930052 |
| GSE13712_STATIC | Up | 0.1071099082 |
| GSE19018 | Down | -0.0011888880 |
| GSE19899_A1 | Up | 0.1224548973 |
| GSE19899_A2 | Up | 0.0762744846 |
| PubMed_21979375_A1 | Up | 0.0392512114 |
| PubMed_21979375_A2 | Up | 0.0936440461 |
| GSE35957 | Down | -0.0106412934 |
| GSE36640 | Down | -0.0121120377 |
| GSE54402 | Up | 0.5725947341 |
| GSE9593 | Down | -0.1069562803 |
| GSE43922 | Up | 0.1350038117 |
| GSE24585 | Down | -0.0639150457 |
| GSE37065 | Down | -0.0356201088 |
| GSE28863_A1 | Down | -0.1747897131 |
| GSE28863_A2 | Down | -0.1451387348 |
| GSE28863_A3 | Up | 0.2804472706 |
| GSE28863_A4 | Up | 0.0311846810 |
| GSE48662 | Down | -0.0364553091 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-186-5p | MIMAT0000456 | MIRT021103 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-128-3p | MIMAT0000424 | MIRT021908 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-183-5p | MIMAT0000261 | MIRT025027 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-32-5p | MIMAT0000090 | MIRT028285 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT028968 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031515 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031515 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26096706 | B cell CLL/lymphoma 11B (Bcl11b), a C2H2 zinc finger transcription factor, not only serves as a critical regulator in development but also plays the controversial role in T cell acute lymphoblastic leukemia (T-ALL) |
| 26096706 | We previously found that the enriched expression of Bcl11b was detected in high tumorigenic C6 glioma cells |
| 26096706 | However, the role of Bcl11b in glioma malignancy and its mechanisms remains to be uncovered |
| 26096706 | In this study, using the lentivirus-mediated knockdown (KD) approach, we found that Bcl11b KD in tumorigenic C6 cells reduced the cell proliferation, colony formation, and migratory ability |
| 26096706 | These results suggest that the ablation of Bcl11b gene expression induced glioma cell senescence |
| 26096706 | Together, this is the first study to show that the inhibition of Bcl11b suppresses glioma cell growth by regulating the expression of the cell cycle regulator p21 and stemness-associated genes (Sox-2/Bmi-1) |
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