HCSGD entry for DEPTOR
1. General information
| Official gene symbol | DEPTOR |
|---|---|
| Entrez ID | 64798 |
| Gene full name | DEP domain containing MTOR-interacting protein |
| Other gene symbols | DEP.6 DEPDC6 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005622 | Intracellular | IDA | cellular_component |
| GO:0006469 | Negative regulation of protein kinase activity | IMP | biological_process |
| GO:0032007 | Negative regulation of TOR signaling | IMP | biological_process |
| GO:0035556 | Intracellular signal transduction | IEA | biological_process |
| GO:0045792 | Negative regulation of cell size | IMP | biological_process |
| GO:2001236 | Regulation of extrinsic apoptotic signaling pathway | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1466419209 | 0.0910969454 | 0.7671957861 | 0.5739020345 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.6191896379 |
| GSE13712_SHEAR | Down | -0.2006470694 |
| GSE13712_STATIC | Up | 0.0559130145 |
| GSE19018 | Up | 0.1335388703 |
| GSE19899_A1 | Up | 0.0565778687 |
| GSE19899_A2 | Up | 0.0794291766 |
| PubMed_21979375_A1 | Down | -0.0000916760 |
| PubMed_21979375_A2 | Up | 0.3088741786 |
| GSE35957 | Up | 0.7324978430 |
| GSE36640 | Up | 0.3368260894 |
| GSE54402 | Down | -0.2332113205 |
| GSE9593 | Down | -0.0583201020 |
| GSE43922 | Up | 0.1993727316 |
| GSE24585 | Down | -0.7767131691 |
| GSE37065 | Down | -0.7299004871 |
| GSE28863_A1 | Up | 0.4720008973 |
| GSE28863_A2 | Up | 0.1258778808 |
| GSE28863_A3 | Up | 0.3755409538 |
| GSE28863_A4 | Down | -0.3503037755 |
| GSE48662 | Down | -0.0474132221 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 22160218 | In this report, we identified a mammalian target of rapamycin (mTOR) inhibitor (DEP domain containing MTOR-interacting protein [DEPDC6/DEPTOR]) as a GNMT-binding protein by using yeast two-hybrid screening |
| 22160218 | Fluorescence resonance energy transfer assay demonstrated that the C-terminal half of GNMT interact with the PSD-95/Dlg1/ZO-1 (PDZ) domain of DEPDC6/DEPTOR |
| 22160218 | In terms of molecular mechanism, knockdown of DEPDC6/DEPTOR expression in HuH-7 cells caused S6K and 4E-BP activation, but suppressed Akt |
| 22160218 | Overexpression of DEPDC6/DEPTOR activated Akt and increased survival of HCC cells |
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