HCSGD entry for SIAH2
1. General information
| Official gene symbol | SIAH2 |
|---|---|
| Entrez ID | 6478 |
| Gene full name | siah E3 ubiquitin protein ligase 2 |
| Other gene symbols | hSiah2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003714 | Transcription corepressor activity | TAS | molecular_function |
| GO:0004842 | Ubiquitin-protein ligase activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005737 | Cytoplasm | TAS | cellular_component |
| GO:0005769 | Early endosome | IEA | cellular_component |
| GO:0005829 | Cytosol | IDA IEA TAS | cellular_component |
| GO:0006511 | Ubiquitin-dependent protein catabolic process | IEA | biological_process |
| GO:0007049 | Cell cycle | IEA | biological_process |
| GO:0007264 | Small GTPase mediated signal transduction | TAS | biological_process |
| GO:0007275 | Multicellular organismal development | IEA | biological_process |
| GO:0007411 | Axon guidance | TAS | biological_process |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0031396 | Regulation of protein ubiquitination | IEA | biological_process |
| GO:0031624 | Ubiquitin conjugating enzyme binding | IEA | molecular_function |
| GO:0043005 | Neuron projection | IEA | cellular_component |
| GO:0043025 | Neuronal cell body | IEA | cellular_component |
| GO:0043066 | Negative regulation of apoptotic process | IMP | biological_process |
| GO:0043154 | Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process | IMP | biological_process |
| GO:0044257 | Cellular protein catabolic process | IGI | biological_process |
| GO:0090090 | Negative regulation of canonical Wnt signaling pathway | IGI | biological_process |
| GO:2001141 | Regulation of RNA biosynthetic process | TAS | biological_process |
| GO:2001237 | Negative regulation of extrinsic apoptotic signaling pathway | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8618778124 | 0.0852811595 | 0.9999902473 | 0.5542134535 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -1.0593173727 |
| GSE13712_SHEAR | Up | 0.0611689234 |
| GSE13712_STATIC | Down | -0.0033128683 |
| GSE19018 | Up | 0.5332342513 |
| GSE19899_A1 | Down | -0.0084996339 |
| GSE19899_A2 | Down | -0.0849126186 |
| PubMed_21979375_A1 | Up | 0.0424234274 |
| PubMed_21979375_A2 | Down | -0.5975179533 |
| GSE35957 | Down | -0.2702299367 |
| GSE36640 | Down | -0.2293329272 |
| GSE54402 | Down | -0.1610641981 |
| GSE9593 | Down | -0.0132448033 |
| GSE43922 | Up | 0.0509271953 |
| GSE24585 | Down | -0.1345901022 |
| GSE37065 | Down | -0.1710809603 |
| GSE28863_A1 | Down | -0.1471685545 |
| GSE28863_A2 | Down | -0.0198321945 |
| GSE28863_A3 | Down | -0.0886073832 |
| GSE28863_A4 | Down | -0.1323502942 |
| GSE48662 | Up | 0.4347626191 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-503-5p | MIMAT0002874 | MIRT041115 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-30c-5p | MIMAT0000244 | MIRT047977 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
