HCSGD entry for SHMT1

1. General information

Official gene symbolSHMT1
Entrez ID6470
Gene full nameserine hydroxymethyltransferase 1 (soluble)
Other gene symbolsCSHMT SHMT
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004372Glycine hydroxymethyltransferase activityIDA IEA TASmolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005739MitochondrionIEAcellular_component
GO:0005829CytosolIDA IEA TAScellular_component
GO:0006544Glycine metabolic processIEAbiological_process
GO:0006563L-serine metabolic processIEAbiological_process
GO:0006565L-serine catabolic processIDAbiological_process
GO:0006766Vitamin metabolic processTASbiological_process
GO:0006767Water-soluble vitamin metabolic processTASbiological_process
GO:0008168Methyltransferase activityIEAmolecular_function
GO:0008242Omega peptidase activityIEAmolecular_function
GO:0008732L-allo-threonine aldolase activityIEAmolecular_function
GO:0009113Purine nucleobase biosynthetic processIDAbiological_process
GO:0016597Amino acid bindingIEAmolecular_function
GO:0019264Glycine biosynthetic process from serineIEAbiological_process
GO:0030170Pyridoxal phosphate bindingIDA IEAmolecular_function
GO:0034641Cellular nitrogen compound metabolic processTASbiological_process
GO:0035999Tetrahydrofolate interconversionIEAbiological_process
GO:0042802Identical protein bindingIEAmolecular_function
GO:0042803Protein homodimerization activityIDAmolecular_function
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045329Carnitine biosynthetic processTASbiological_process
GO:0046655Folic acid metabolic processIDA TASbiological_process
GO:0051262Protein tetramerizationIDAbiological_process
GO:0051289Protein homotetramerizationIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.97061427000.08500024320.99999024730.5531004697

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0884359722
GSE13712_SHEARDown-0.0272038544
GSE13712_STATICUp0.2368377436
GSE19018Up0.0785032729
GSE19899_A1Up0.0693175645
GSE19899_A2Down-0.1948329330
PubMed_21979375_A1Down-0.4853145078
PubMed_21979375_A2Down-0.2841700623
GSE35957Down-0.0260276713
GSE36640Down-1.6440601680
GSE54402Down-0.4207871190
GSE9593Down-0.0514679282
GSE43922--
GSE24585--
GSE37065--
GSE28863_A1Down-0.0610278767
GSE28863_A2Up0.0780404593
GSE28863_A3Up0.0259191791
GSE28863_A4Up0.1030358137
GSE48662Down-0.7723728804

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Tetrahydrofolic acidDB00116 NUTR00056
GlycineDB00145 NUTR00028
MimosineDB01055 APRD00647
Triglu-5-Formyl-TetrahydrofolateDB02067 EXPT03045
5-Hydroxymethylene-6-Hydrofolic AcidDB02800 EXPT03049
N-Pyridoxyl-Glycine-5-MonophosphateDB02824 EXPT02606

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-193b-3pMIMAT0002819MIRT016266MicroarrayFunctional MTI (Weak)20304954
hsa-miR-125b-5pMIMAT0000423MIRT045899CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.