HCSGD entry for SHC1

1. General information

Official gene symbolSHC1
Entrez ID6464
Gene full nameSHC (Src homology 2 domain containing) transforming protein 1
Other gene symbolsSHC SHCA
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000165MAPK cascadeIDAbiological_process
GO:0000187Activation of MAPK activityIDA IEAbiological_process
GO:0001525AngiogenesisIEAbiological_process
GO:0004713Protein tyrosine kinase activityTASmolecular_function
GO:0005068Transmembrane receptor protein tyrosine kinase adaptor activityTASmolecular_function
GO:0005154Epidermal growth factor receptor bindingISSmolecular_function
GO:0005158Insulin receptor bindingIPImolecular_function
GO:0005159Insulin-like growth factor receptor bindingIPImolecular_function
GO:0005168Neurotrophin TRKA receptor bindingIPImolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005543Phospholipid bindingTASmolecular_function
GO:0005759Mitochondrial matrixIEAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005886Plasma membraneIDA TAScellular_component
GO:0006468Protein phosphorylationTASbiological_process
GO:0006987Activation of signaling protein activity involved in unfolded protein responseTASbiological_process
GO:0007173Epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0007176Regulation of epidermal growth factor-activated receptor activityTASbiological_process
GO:0007265Ras protein signal transductionTASbiological_process
GO:0007507Heart developmentIEAbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0008284Positive regulation of cell proliferationNASbiological_process
GO:0008286Insulin receptor signaling pathwayISS TASbiological_process
GO:0008543Fibroblast growth factor receptor signaling pathwayTASbiological_process
GO:0016337Cell-cell adhesionIEAbiological_process
GO:0018108Peptidyl-tyrosine phosphorylationTASbiological_process
GO:0030168Platelet activationTASbiological_process
GO:0030968Endoplasmic reticulum unfolded protein responseTASbiological_process
GO:0030971Receptor tyrosine kinase bindingIEAmolecular_function
GO:0031532Actin cytoskeleton reorganizationIEAbiological_process
GO:0035556Intracellular signal transductionIEAbiological_process
GO:0038095Fc-epsilon receptor signaling pathwayTASbiological_process
GO:0040008Regulation of growthIEAbiological_process
GO:0044267Cellular protein metabolic processTASbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0045740Positive regulation of DNA replicationISSbiological_process
GO:0046875Ephrin receptor bindingIEA IPImolecular_function
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0050900Leukocyte migrationTASbiological_process
GO:0070435Shc-EGFR complexISScellular_component
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00530294060.99686611070.19042114601.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.7121364370
GSE13712_SHEARUp0.1385623513
GSE13712_STATICUp0.1982379813
GSE19018Up0.1547783709
GSE19899_A1Up0.4824071432
GSE19899_A2Up1.2535343923
PubMed_21979375_A1Up0.5129361179
PubMed_21979375_A2Up1.0457794111
GSE35957Up0.0864258195
GSE36640Up0.8093835117
GSE54402Up0.3671418751
GSE9593Up0.1730983601
GSE43922Up0.4191023106
GSE24585Up0.1155911255
GSE37065Down-0.0826786977
GSE28863_A1--
GSE28863_A2--
GSE28863_A3--
GSE28863_A4--
GSE48662Up0.1347328216

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-429MIMAT0001536MIRT016646Reporter assayFunctional MTI20005803
hsa-miR-200a-3pMIMAT0000682MIRT020350Reporter assayFunctional MTI20005803
hsa-miR-200c-3pMIMAT0000617MIRT021079Reporter assayFunctional MTI20005803
hsa-miR-141-3pMIMAT0000432MIRT021650Reporter assayFunctional MTI20005803
hsa-miR-124-3pMIMAT0000422MIRT023035MicroarrayFunctional MTI (Weak)18668037
hsa-miR-200b-3pMIMAT0000318MIRT024134Reporter assayFunctional MTI20005803
hsa-miR-30b-5pMIMAT0000420MIRT046156CLASHFunctional MTI (Weak)23622248
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    • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-204-5pMIMAT0000265NAhsa-miR-20420369013
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26992231Here we show that NSUN2 methylates SHC mRNA in vitro and in cells, thereby enhancing the translation of the three SHC proteins, p66SHC, p52SHC, and p46SHC
26992231Our results further show that the elevation of SHC expression by NSUN2-mediated mRNA methylation increased the levels of ROS, activated p38MAPK, thereby accelerating oxidative stress- and high-glucose-induced senescence of human vascular endothelial cells (HUVEC)
14499637Herein, we show that EGFR signaling as determined by receptor autophosphorylation is diminished over 80%, with a corresponding decrease in the phosphorylation of the immediate postreceptor adaptor Shc
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