HCSGD entry for BLVRA
1. General information
| Official gene symbol | BLVRA |
|---|---|
| Entrez ID | 644 |
| Gene full name | biliverdin reductase A |
| Other gene symbols | BLVR BVR BVRA |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004074 | Biliverdin reductase activity | IDA | molecular_function |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006778 | Porphyrin-containing compound metabolic process | TAS | biological_process |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0016491 | Oxidoreductase activity | IEA | molecular_function |
| GO:0042167 | Heme catabolic process | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0055114 | Oxidation-reduction process | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9835490559 | 0.0114609741 | 0.9999902473 | 0.2122901478 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.2150153701 |
| GSE13712_SHEAR | Down | -0.1374805328 |
| GSE13712_STATIC | Up | 0.1095972159 |
| GSE19018 | Down | -0.1269549343 |
| GSE19899_A1 | Down | -0.4932021151 |
| GSE19899_A2 | Down | -0.8045317840 |
| PubMed_21979375_A1 | Down | -1.6955385813 |
| PubMed_21979375_A2 | Down | -1.4466684131 |
| GSE35957 | Down | -0.3223087702 |
| GSE36640 | Down | -0.0762182517 |
| GSE54402 | Down | -0.8389870581 |
| GSE9593 | Up | 0.0461967347 |
| GSE43922 | Down | -0.5452474917 |
| GSE24585 | Down | -0.0921340473 |
| GSE37065 | Down | -0.1358396249 |
| GSE28863_A1 | Up | 0.0317081448 |
| GSE28863_A2 | Up | 0.5830713658 |
| GSE28863_A3 | Down | -0.3377420831 |
| GSE28863_A4 | Up | 0.0136952802 |
| GSE48662 | Down | -0.1923559831 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| NADH | DB00157 | NUTR00041 | DB01907 | EXPT02287 | DB03527 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-17-5p | MIMAT0000070 | MIRT050960 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 22457648 | In this regard, the biliverdin to bilirubin conversion pathway, via biliverdin reductase (BVR), is suggested to be another major protective mechanism that scavenges lipophilic oxidants because of the lipophilic nature of bilirubin |
| 22457648 | The efficiency of this bilirubin system might be potentiated by operation of the intertwined bicyclic systems of the suggested redox metabolic cycle of biliverdin and bilirubin and the interactive control cycle of BVR and heme oxygenase |
| 21099244 | Biliverdin reductase A in the prevention of cellular senescence against oxidative stress |
| 21099244 | Biliverdin reductase A (BLVRA), an enzyme that converts biliverdin to bilirubin, has recently emerged as a key regulator of the cellular redox cycle |
| 21099244 | However, the role of BLVRA in the aging process remains unclear |
| 21099244 | To study the role of BLVRA in the aging process, we compared the stress responses of young and senescent human diploid fibroblasts (HDFs) to the reactive oxygen species (ROS) inducer, hydrogen peroxide (H2O2) |
| 21099244 | H2O2 markedly induced BLVRA activity in young HDFs, but not in senescent HDFs |
| 21099244 | Additionally, depletion of BLVRA reduced the H2O2-dependent induction of heme oxygenase-1 (HO-1) in young HDFs, but not in senescent cells, suggesting an aging-dependent differential modulation of responses to oxidative stress |
| 21099244 | The role of BLVRA in the regulation of cellular senescence was confirmed when lentiviral RNAi- transfected stable primary HDFs with reduced BLVRA expression showed upregulation of the CDK inhibitor family members p16, p53, and p21, followed by cell cycle arrest in G0-G1 phase with high expression of senescence-associated beta-galactosidase |
| 21099244 | Taken together, these data support the notion that BLVRA contributes significantly to modulation of the aging process by adjusting the cellular oxidative status |
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