HCSGD entry for SRSF6
1. General information
| Official gene symbol | SRSF6 |
|---|---|
| Entrez ID | 6431 |
| Gene full name | serine/arginine-rich splicing factor 6 |
| Other gene symbols | B52 SFRS6 SRP55 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000166 | Nucleotide binding | IEA | molecular_function |
| GO:0000381 | Regulation of alternative mRNA splicing, via spliceosome | IDA | biological_process |
| GO:0000398 | MRNA splicing, via spliceosome | TAS | biological_process |
| GO:0003723 | RNA binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0006366 | Transcription from RNA polymerase II promoter | TAS | biological_process |
| GO:0006369 | Termination of RNA polymerase II transcription | TAS | biological_process |
| GO:0006376 | MRNA splice site selection | TAS | biological_process |
| GO:0006406 | MRNA export from nucleus | TAS | biological_process |
| GO:0008380 | RNA splicing | TAS | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0031124 | MRNA 3'-end processing | TAS | biological_process |
| GO:0048025 | Negative regulation of mRNA splicing, via spliceosome | IDA | biological_process |
| GO:0060501 | Positive regulation of epithelial cell proliferation involved in lung morphogenesis | IDA | biological_process |
| GO:0060548 | Negative regulation of cell death | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8523040918 | 0.0068369667 | 0.9999902473 | 0.1653088342 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.6560653856 |
| GSE13712_SHEAR | Down | -0.0070598558 |
| GSE13712_STATIC | Up | 0.3257792847 |
| GSE19018 | Down | -0.9834350392 |
| GSE19899_A1 | Down | -1.0578408823 |
| GSE19899_A2 | Down | -0.7860800839 |
| PubMed_21979375_A1 | Down | -0.6175890011 |
| PubMed_21979375_A2 | Down | -0.7947873963 |
| GSE35957 | Up | 0.3506463066 |
| GSE36640 | Down | -0.6131626771 |
| GSE54402 | Down | -0.3008878189 |
| GSE9593 | Down | -0.7653694400 |
| GSE43922 | Down | -0.2698742325 |
| GSE24585 | Up | 0.1783699140 |
| GSE37065 | Down | -0.1479571318 |
| GSE28863_A1 | Up | 0.4187876434 |
| GSE28863_A2 | Down | -0.0274113458 |
| GSE28863_A3 | Down | -0.1884905037 |
| GSE28863_A4 | Up | 0.0783264583 |
| GSE48662 | Up | 0.2680987409 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-186-5p | MIMAT0000456 | MIRT021143 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-1 | MIMAT0000416 | MIRT023804 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029475 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-18a-5p | MIMAT0000072 | MIRT050719 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
