HCSGD entry for SRSF4
1. General information
| Official gene symbol | SRSF4 |
|---|---|
| Entrez ID | 6429 |
| Gene full name | serine/arginine-rich splicing factor 4 |
| Other gene symbols | SFRS4 SRP75 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000166 | Nucleotide binding | IEA | molecular_function |
| GO:0000375 | RNA splicing, via transesterification reactions | TAS | biological_process |
| GO:0000398 | MRNA splicing, via spliceosome | TAS | biological_process |
| GO:0003676 | Nucleic acid binding | IEA | molecular_function |
| GO:0003723 | RNA binding | IEA | molecular_function |
| GO:0005634 | Nucleus | TAS | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0006366 | Transcription from RNA polymerase II promoter | TAS | biological_process |
| GO:0006369 | Termination of RNA polymerase II transcription | TAS | biological_process |
| GO:0006397 | MRNA processing | TAS | biological_process |
| GO:0006406 | MRNA export from nucleus | TAS | biological_process |
| GO:0008380 | RNA splicing | TAS | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0016607 | Nuclear speck | IEA | cellular_component |
| GO:0031124 | MRNA 3'-end processing | TAS | biological_process |
| GO:0048025 | Negative regulation of mRNA splicing, via spliceosome | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7454458645 | 0.1614885301 | 0.9999902473 | 0.7758352072 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1642544188 |
| GSE13712_SHEAR | Up | 0.4559969455 |
| GSE13712_STATIC | Up | 0.2816908433 |
| GSE19018 | Down | -0.4555170547 |
| GSE19899_A1 | Down | -0.1213077579 |
| GSE19899_A2 | Down | -0.3160475289 |
| PubMed_21979375_A1 | Down | -0.2001850715 |
| PubMed_21979375_A2 | Up | 0.0978684858 |
| GSE35957 | Down | -0.1153257214 |
| GSE36640 | Down | -0.8259668097 |
| GSE54402 | Up | 0.1767935319 |
| GSE9593 | Down | -0.1205127616 |
| GSE43922 | Down | -0.0374852948 |
| GSE24585 | Up | 0.1708784948 |
| GSE37065 | Up | 0.0070555934 |
| GSE28863_A1 | Up | 0.0740368675 |
| GSE28863_A2 | Up | 0.2738224739 |
| GSE28863_A3 | Down | -0.0549866045 |
| GSE28863_A4 | Down | -0.1438059986 |
| GSE48662 | Down | -0.3484310391 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | MIRT023667 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-1913 | MIMAT0007888 | MIRT035798 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-1180-3p | MIMAT0005825 | MIRT035954 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-877-3p | MIMAT0004950 | MIRT036942 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-769-5p | MIMAT0003886 | MIRT039215 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
