HCSGD entry for SRSF3
1. General information
| Official gene symbol | SRSF3 |
|---|---|
| Entrez ID | 6428 |
| Gene full name | serine/arginine-rich splicing factor 3 |
| Other gene symbols | SFRS3 SRp20 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000166 | Nucleotide binding | IEA | molecular_function |
| GO:0000398 | MRNA splicing, via spliceosome | TAS | biological_process |
| GO:0003723 | RNA binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0006366 | Transcription from RNA polymerase II promoter | TAS | biological_process |
| GO:0006369 | Termination of RNA polymerase II transcription | TAS | biological_process |
| GO:0006406 | MRNA export from nucleus | TAS | biological_process |
| GO:0008380 | RNA splicing | TAS | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0031124 | MRNA 3'-end processing | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9974010904 | 0.0016995099 | 0.9999902473 | 0.0791730973 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.3600655305 |
| GSE13712_SHEAR | Down | -0.1455227724 |
| GSE13712_STATIC | Down | -0.0156896470 |
| GSE19018 | Down | -0.9010726824 |
| GSE19899_A1 | Down | -0.5684560002 |
| GSE19899_A2 | Down | -1.1381513232 |
| PubMed_21979375_A1 | Down | -1.1564571628 |
| PubMed_21979375_A2 | Down | -0.8805212286 |
| GSE35957 | Down | -0.2931871719 |
| GSE36640 | Down | -0.8762434809 |
| GSE54402 | Down | -0.3200676879 |
| GSE9593 | Down | -0.3596733742 |
| GSE43922 | Down | -0.5127809651 |
| GSE24585 | Down | -0.1999054444 |
| GSE37065 | Down | -0.1848191750 |
| GSE28863_A1 | Up | 0.2295032875 |
| GSE28863_A2 | Up | 0.2339776013 |
| GSE28863_A3 | Down | -0.5971306177 |
| GSE28863_A4 | Down | -0.3842739085 |
| GSE48662 | Down | -0.6529849421 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-361-5p | MIMAT0000703 | MIRT020093 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-186-5p | MIMAT0000456 | MIRT021093 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT022320 | Proteomics;Microarray | Non-Functional MTI (Weak) | 18668037 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 22777358 | Downregulation of splicing factor SRSF3 induces p53beta, an alternatively spliced isoform of p53 that promotes cellular senescence |
| 22777358 | SRSF3 (SRp20) is a member of a highly conserved family of splicing factors that have critical roles in key biological processes, including tumor progression |
| 22777358 | Downregulation of SRSF3 was observed in normal human fibroblasts undergoing replicative senescence, and was associated with the upregulation of p53beta, an alternatively spliced isoform of p53 that promotes p53-mediated senescence |
| 22777358 | Knockdown of SRSF3 by short interfering RNA (siRNA) in early-passage fibroblasts induced senescence, which was associated with elevated expression of p53beta at mRNA and protein levels |
| 22777358 | Knockdown of p53 partially rescued SRSF3-knockdown-induced senescence, suggesting that SRSF3 acts on p53-mediated cellular senescence |
| 22777358 | RNA pulldown assays demonstrated that SRSF3 binds to an alternatively spliced exon uniquely included in p53beta mRNA through the consensus SRSF3-binding sequences |
| 22777358 | RNA crosslinking and immunoprecipitation assays (CLIP) also showed that SRSF3 in vivo binds to endogenous p53 pre-mRNA at the region containing the p53beta-unique exon |
| 22777358 | Splicing assays using a transfected TP53 minigene in combination with siRNA knockdown of SRSF3 showed that SRSF3 functions to inhibit the inclusion of the p53beta-unique exon in splicing of p53 pre-mRNA |
| 22777358 | These data suggest that downregulation of SRSF3 represents an endogenous mechanism for cellular senescence that directly regulates the TP53 alternative splicing to generate p53beta |
| 22777358 | This study uncovers the role for general splicing machinery in tumorigenesis, and suggests that SRSF3 is a direct regulator of p53 |
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