HCSGD entry for ABCG8
1. General information
| Official gene symbol | ABCG8 |
|---|---|
| Entrez ID | 64241 |
| Gene full name | ATP-binding cassette, sub-family G (WHITE), member 8 |
| Other gene symbols | GBD4 STSL |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IDA | molecular_function |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0006200 | ATP catabolic process | IDA | biological_process |
| GO:0007584 | Response to nutrient | IEA | biological_process |
| GO:0007588 | Excretion | IGI | biological_process |
| GO:0010949 | Negative regulation of intestinal phytosterol absorption | IMP | biological_process |
| GO:0015914 | Phospholipid transport | IEA | biological_process |
| GO:0015918 | Sterol transport | TAS | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0016324 | Apical plasma membrane | IMP | cellular_component |
| GO:0016887 | ATPase activity | IDA | molecular_function |
| GO:0017127 | Cholesterol transporter activity | IGI | molecular_function |
| GO:0030299 | Intestinal cholesterol absorption | IC | biological_process |
| GO:0033344 | Cholesterol efflux | IGI | biological_process |
| GO:0042493 | Response to drug | IEA | biological_process |
| GO:0042632 | Cholesterol homeostasis | IMP | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0045796 | Negative regulation of intestinal cholesterol absorption | IMP | biological_process |
| GO:0046982 | Protein heterodimerization activity | IPI | molecular_function |
| GO:0055085 | Transmembrane transport | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5755663121 | 0.9007987121 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0375110654 |
| GSE13712_SHEAR | Up | 0.1282821850 |
| GSE13712_STATIC | Down | -0.1707252076 |
| GSE19018 | Up | 0.0239262044 |
| GSE19899_A1 | Up | 0.1418651547 |
| GSE19899_A2 | Up | 0.2194365638 |
| PubMed_21979375_A1 | Up | 0.0367328620 |
| PubMed_21979375_A2 | Up | 0.1786246830 |
| GSE35957 | Up | 0.0141694709 |
| GSE36640 | Up | 0.0125908347 |
| GSE54402 | Down | -0.0354886614 |
| GSE9593 | Up | 0.0381919222 |
| GSE43922 | Up | 0.0256262748 |
| GSE24585 | Up | 0.0010392407 |
| GSE37065 | Down | -0.0140313018 |
| GSE28863_A1 | Down | -0.0436352155 |
| GSE28863_A2 | Up | 0.1842728669 |
| GSE28863_A3 | Up | 0.1716054031 |
| GSE28863_A4 | Up | 0.0724712502 |
| GSE48662 | Down | -0.0167963732 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT017992 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT022678 | Microarray | Functional MTI (Weak) | 18668037 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
