HCSGD entry for SFRP2

1. General information

Official gene symbolSFRP2
Entrez ID6423
Gene full namesecreted frizzled-related protein 2
Other gene symbolsFRP-2 SARP1 SDF-5
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001569Patterning of blood vesselsISSbiological_process
GO:0001843Neural tube closureIEAbiological_process
GO:0001944Vasculature developmentIBAbiological_process
GO:0001968Fibronectin bindingISSmolecular_function
GO:0002063Chondrocyte developmentIEAbiological_process
GO:0003151Outflow tract morphogenesisIMPbiological_process
GO:0003214Cardiac left ventricle morphogenesisIMPbiological_process
GO:0005178Integrin bindingISSmolecular_function
GO:0005615Extracellular spaceIDA ISScellular_component
GO:0005737CytoplasmIBAcellular_component
GO:0005886Plasma membraneIBAcellular_component
GO:0007267Cell-cell signalingISSbiological_process
GO:0007420Brain developmentIBAbiological_process
GO:0007584Response to nutrientIEAbiological_process
GO:0008284Positive regulation of cell proliferationIDAbiological_process
GO:0008285Negative regulation of cell proliferationIDA IMPbiological_process
GO:0008406Gonad developmentIBAbiological_process
GO:0008584Male gonad developmentIEAbiological_process
GO:0009790Embryo developmentIBAbiological_process
GO:0010469Regulation of receptor activityISSbiological_process
GO:0010577Metalloenzyme activator activityIEAmolecular_function
GO:0010629Negative regulation of gene expressionISSbiological_process
GO:0010667Negative regulation of cardiac muscle cell apoptotic processIEAbiological_process
GO:0010719Negative regulation of epithelial to mesenchymal transitionIDAbiological_process
GO:0017147Wnt-protein bindingIBAmolecular_function
GO:0030165PDZ domain bindingIBAmolecular_function
GO:0030178Negative regulation of Wnt signaling pathwayIDAbiological_process
GO:0030199Collagen fibril organizationIEAbiological_process
GO:0030307Positive regulation of cell growthISSbiological_process
GO:0030308Negative regulation of cell growthIDAbiological_process
GO:0030336Negative regulation of cell migrationISSbiological_process
GO:0030514Negative regulation of BMP signaling pathwayIEAbiological_process
GO:0031012Extracellular matrixISScellular_component
GO:0031668Cellular response to extracellular stimulusIEAbiological_process
GO:0033138Positive regulation of peptidyl-serine phosphorylationISSbiological_process
GO:0033630Positive regulation of cell adhesion mediated by integrinISSbiological_process
GO:0035413Positive regulation of catenin import into nucleusIEAbiological_process
GO:0036342Post-anal tail morphogenesisIEAbiological_process
GO:0042493Response to drugIEAbiological_process
GO:0042662Negative regulation of mesodermal cell fate specificationIEAbiological_process
GO:0042733Embryonic digit morphogenesisIEAbiological_process
GO:0042813Wnt-activated receptor activityIBAmolecular_function
GO:0042995Cell projectionIKRcellular_component
GO:0043065Positive regulation of apoptotic processIMPbiological_process
GO:0043154Negative regulation of cysteine-type endopeptidase activity involved in apoptotic processIEAbiological_process
GO:0043508Negative regulation of JUN kinase activityIEAbiological_process
GO:0045600Positive regulation of fat cell differentiationIDAbiological_process
GO:0045669Positive regulation of osteoblast differentiationIEAbiological_process
GO:0045766Positive regulation of angiogenesisISSbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedIDAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterISSbiological_process
GO:0048018Receptor agonist activityISSmolecular_function
GO:0048546Digestive tract morphogenesisIEAbiological_process
GO:0050680Negative regulation of epithelial cell proliferationIDAbiological_process
GO:0050732Negative regulation of peptidyl-tyrosine phosphorylationISSbiological_process
GO:0060028Convergent extension involved in axis elongationIEAbiological_process
GO:0060349Bone morphogenesisIEAbiological_process
GO:0061056Sclerotome developmentISSbiological_process
GO:0061133Endopeptidase activator activityIEAmolecular_function
GO:0061185Negative regulation of dermatome developmentISSbiological_process
GO:0071425Hematopoietic stem cell proliferationISSbiological_process
GO:0071481Cellular response to X-rayIEAbiological_process
GO:0090090Negative regulation of canonical Wnt signaling pathwayIDAbiological_process
GO:0090179Planar cell polarity pathway involved in neural tube closureIEAbiological_process
GO:0090244Wnt signaling pathway involved in somitogenesisIEAbiological_process
GO:0090263Positive regulation of canonical Wnt signaling pathwayISSbiological_process
GO:1902042Negative regulation of extrinsic apoptotic signaling pathway via death domain receptorsIEAbiological_process
GO:1902230Negative regulation of intrinsic apoptotic signaling pathway in response to DNA damageISSbiological_process
GO:2000035Regulation of stem cell divisionISSbiological_process
GO:2000041Negative regulation of planar cell polarity pathway involved in axis elongationIEAbiological_process
GO:2000273Positive regulation of receptor activityISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00387100790.95010677030.16724426231.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1200010375
GSE13712_SHEARDown-0.0774079822
GSE13712_STATICDown-0.0792235495
GSE19018Up0.0847400179
GSE19899_A1Up0.2883281053
GSE19899_A2Up0.0905320770
PubMed_21979375_A1Up0.2856651714
PubMed_21979375_A2Up0.2159608214
GSE35957Up0.3599732976
GSE36640Up0.0606464204
GSE54402Up0.5131093610
GSE9593Up0.8225599039
GSE43922Up0.0063569201
GSE24585Up0.0309740918
GSE37065Up0.7037878026
GSE28863_A1Up1.1383078368
GSE28863_A2Up0.9935508523
GSE28863_A3Up1.8396979439
GSE28863_A4Down-0.3578121255
GSE48662Up0.0545948355

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-29a-3pMIMAT0000086MIRT003607Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI20551325
hsa-miR-218-5pMIMAT0000275MIRT006749Luciferase reporter assayFunctional MTI23060446
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.