HCSGD entry for SFRP1

1. General information

Official gene symbolSFRP1
Entrez ID6422
Gene full namesecreted frizzled-related protein 1
Other gene symbolsFRP FRP-1 FRP1 FrzA SARP2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001649Osteoblast differentiationIEPbiological_process
GO:0001657Ureteric bud developmentIEAbiological_process
GO:0001843Neural tube closureIEAbiological_process
GO:0001944Vasculature developmentIBAbiological_process
GO:0001954Positive regulation of cell-matrix adhesionISSbiological_process
GO:0002244Hematopoietic progenitor cell differentiationIDAbiological_process
GO:0004197Cysteine-type endopeptidase activityIMPmolecular_function
GO:0005109Frizzled bindingIPImolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionIEAcellular_component
GO:0005578Proteinaceous extracellular matrixIDAcellular_component
GO:0005615Extracellular spaceIDAcellular_component
GO:0005622IntracellularIDAcellular_component
GO:0005829CytosolIDAcellular_component
GO:0005886Plasma membraneIBA ISScellular_component
GO:0006309Apoptotic DNA fragmentationIDAbiological_process
GO:0007420Brain developmentIBAbiological_process
GO:0008144Drug bindingIDAmolecular_function
GO:0008201Heparin bindingIDAmolecular_function
GO:0008284Positive regulation of cell proliferationIDAbiological_process
GO:0008285Negative regulation of cell proliferationIDAbiological_process
GO:0008406Gonad developmentIBAbiological_process
GO:0008584Male gonad developmentIEAbiological_process
GO:0008585Female gonad developmentIEAbiological_process
GO:0009267Cellular response to starvationIEPbiological_process
GO:0009790Embryo developmentIBAbiological_process
GO:0009950Dorsal/ventral axis specificationIDAbiological_process
GO:0009986Cell surfaceIDAcellular_component
GO:0010564Regulation of cell cycle processIMPbiological_process
GO:0010629Negative regulation of gene expressionIDAbiological_process
GO:0010719Negative regulation of epithelial to mesenchymal transitionIDAbiological_process
GO:0014034Neural crest cell fate commitmentIEAbiological_process
GO:0014070Response to organic cyclic compoundIDAbiological_process
GO:0017147Wnt-protein bindingIPImolecular_function
GO:0022601Menstrual cycle phaseIEPbiological_process
GO:0030165PDZ domain bindingIBAmolecular_function
GO:0030177Positive regulation of Wnt signaling pathwayIDAbiological_process
GO:0030178Negative regulation of Wnt signaling pathwayIDA IMPbiological_process
GO:0030279Negative regulation of ossificationIDA IMPbiological_process
GO:0030307Positive regulation of cell growthIDAbiological_process
GO:0030308Negative regulation of cell growthIDAbiological_process
GO:0030336Negative regulation of cell migrationIDAbiological_process
GO:0030514Negative regulation of BMP signaling pathwayIEAbiological_process
GO:0031012Extracellular matrixIDAcellular_component
GO:0032855Positive regulation of Rac GTPase activityISSbiological_process
GO:0033689Negative regulation of osteoblast proliferationIMPbiological_process
GO:0035019Somatic stem cell maintenanceIEAbiological_process
GO:0042493Response to drugIDAbiological_process
GO:0042802Identical protein bindingIPImolecular_function
GO:0042813Wnt-activated receptor activityIBAmolecular_function
GO:0042995Cell projectionIKRcellular_component
GO:0043065Positive regulation of apoptotic processIDA IMPbiological_process
GO:0043066Negative regulation of apoptotic processIMPbiological_process
GO:0043508Negative regulation of JUN kinase activityIEAbiological_process
GO:0044344Cellular response to fibroblast growth factor stimulusIDAbiological_process
GO:0044345Stromal-epithelial cell signaling involved in prostate gland developmentIEAbiological_process
GO:0045578Negative regulation of B cell differentiationIMPbiological_process
GO:0045600Positive regulation of fat cell differentiationIDAbiological_process
GO:0045668Negative regulation of osteoblast differentiationIEAbiological_process
GO:0045671Negative regulation of osteoclast differentiationIEAbiological_process
GO:0045765Regulation of angiogenesisISSbiological_process
GO:0045880Positive regulation of smoothened signaling pathwayIMPbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedIDA IMPbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIDA IMPbiological_process
GO:0046676Negative regulation of insulin secretionIDAbiological_process
GO:0046851Negative regulation of bone remodelingIMPbiological_process
GO:0048147Negative regulation of fibroblast proliferationIDAbiological_process
GO:0048546Digestive tract morphogenesisIEAbiological_process
GO:0050679Positive regulation of epithelial cell proliferationIMPbiological_process
GO:0050680Negative regulation of epithelial cell proliferationIDAbiological_process
GO:0050732Negative regulation of peptidyl-tyrosine phosphorylationIDAbiological_process
GO:0051496Positive regulation of stress fiber assemblyISSbiological_process
GO:0051894Positive regulation of focal adhesion assemblyISSbiological_process
GO:0060070Canonical Wnt signaling pathwayIDAbiological_process
GO:0060218Hematopoietic stem cell differentiationIDAbiological_process
GO:0060346Bone trabecula formationIEAbiological_process
GO:0060527Prostate epithelial cord arborization involved in prostate glandular acinus morphogenesisIEAbiological_process
GO:0060687Regulation of branching involved in prostate gland morphogenesisIEAbiological_process
GO:0060766Negative regulation of androgen receptor signaling pathwayIDAbiological_process
GO:0071305Cellular response to vitamin DIEPbiological_process
GO:0071347Cellular response to interleukin-1IEPbiological_process
GO:0071356Cellular response to tumor necrosis factorIDAbiological_process
GO:0071363Cellular response to growth factor stimulusIDAbiological_process
GO:0071380Cellular response to prostaglandin E stimulusIEPbiological_process
GO:0071391Cellular response to estrogen stimulusIDAbiological_process
GO:0071392Cellular response to estradiol stimulusIEPbiological_process
GO:0071456Cellular response to hypoxiaIEPbiological_process
GO:0071481Cellular response to X-rayIEAbiological_process
GO:0071504Cellular response to heparinIDAbiological_process
GO:0071560Cellular response to transforming growth factor beta stimulusIEPbiological_process
GO:0071773Cellular response to BMP stimulusIEPbiological_process
GO:0090090Negative regulation of canonical Wnt signaling pathwayIDA IMPbiological_process
GO:0090179Planar cell polarity pathway involved in neural tube closureIEAbiological_process
GO:0090244Wnt signaling pathway involved in somitogenesisIEAbiological_process
GO:0090246Convergent extension involved in somitogenesisIEAbiological_process
GO:0090263Positive regulation of canonical Wnt signaling pathwayIDAbiological_process
GO:1902043Positive regulation of extrinsic apoptotic signaling pathway via death domain receptorsIDAbiological_process
GO:2000041Negative regulation of planar cell polarity pathway involved in axis elongationIEAbiological_process
GO:2000052Positive regulation of non-canonical Wnt signaling pathwayIDAbiological_process
GO:2000054Negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specificationIDAbiological_process
GO:2000080Negative regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferationIDAbiological_process
GO:2000117Negative regulation of cysteine-type endopeptidase activityIMPbiological_process
GO:2000270Negative regulation of fibroblast apoptotic processIDAbiological_process
GO:2000271Positive regulation of fibroblast apoptotic processIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.32059646670.00272951260.99999024730.1038200867

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1831317768
GSE13712_SHEARDown-0.6980736201
GSE13712_STATICDown-0.2418409877
GSE19018Up0.7398193286
GSE19899_A1Down-2.6367578111
GSE19899_A2Down-0.6701818027
PubMed_21979375_A1Down-2.2884617810
PubMed_21979375_A2Down-1.1255796874
GSE35957Up0.5149881671
GSE36640Down-0.5157122271
GSE54402Down-1.2555912309
GSE9593Down-0.0778497149
GSE43922Down-1.3879316261
GSE24585Up0.2917735864
GSE37065Up0.4081720587
GSE28863_A1Up0.4775951821
GSE28863_A2Up0.3761835896
GSE28863_A3Up0.2847476232
GSE28863_A4Down-0.3743945873
GSE48662Up0.0154612054

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT017159MicroarrayFunctional MTI (Weak)18185580
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

25915531The etiology remains poorly understood but cellular senescence, increased stiffness of the tissue, and the expression of Wnt antagonists such as secreted frizzled related protein-1 (SFRP1) have been implicated
25915531However, it is not known if senescence is causally linked to either stiffness or SFRP1 expression
25915531In this study, we utilized in vitro HTM senescence to determine the effect on cellular stiffening and SFRP1 expression
25915531SFRP1 expression was measured using qPCR and immunofluorescent analysis
25915531This was accompanied by increased vimentin expression, stress fiber formation, and SFRP1 expression
25915531In aggregate, these data demonstrate that senescence may be a causal factor in HTM stiffening and elevated SFRP1 expression, and contribute towards disease progression
22927647Wnt antagonist SFRP1 functions as a secreted mediator of senescence
22927647Here, we report that secreted Frizzled-related protein 1 (SFRP1), a secreted antagonist of Wnt signaling, is oversecreted upon cellular senescence caused by DNA damage or oxidative stress
22927647SFRP1 is necessary for stress-induced senescence caused by these factors and is sufficient for the induction of senescence phenotypes
22927647We present evidence suggesting that SFRP1 functions as a secreted mediator of senescence through inhibition of Wnt signaling and activation of the retinoblastoma (Rb) pathway and that cancer-associated SFRP1 mutants are defective for senescence induction
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