HCSGD entry for MAP2K4

1. General information

Official gene symbolMAP2K4
Entrez ID6416
Gene full namemitogen-activated protein kinase kinase 4
Other gene symbolsJNKK JNKK1 MAPKK4 MEK4 MKK4 PRKMK4 SAPKK-1 SAPKK1 SEK1 SERK1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002224Toll-like receptor signaling pathwayTASbiological_process
GO:0002755MyD88-dependent toll-like receptor signaling pathwayTASbiological_process
GO:0002756MyD88-independent toll-like receptor signaling pathwayTASbiological_process
GO:0004672Protein kinase activityTASmolecular_function
GO:0004674Protein serine/threonine kinase activityIEAmolecular_function
GO:0004713Protein tyrosine kinase activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005634NucleusIEAcellular_component
GO:0005829CytosolIEA TAScellular_component
GO:0006915Apoptotic processIEAbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007254JNK cascadeTASbiological_process
GO:0008545JUN kinase kinase activityIEAmolecular_function
GO:0031435Mitogen-activated protein kinase kinase kinase bindingIEAmolecular_function
GO:0032839Dendrite cytoplasmIEAcellular_component
GO:0034134Toll-like receptor 2 signaling pathwayTASbiological_process
GO:0034138Toll-like receptor 3 signaling pathwayTASbiological_process
GO:0034142Toll-like receptor 4 signaling pathwayTASbiological_process
GO:0034146Toll-like receptor 5 signaling pathwayTASbiological_process
GO:0034162Toll-like receptor 9 signaling pathwayTASbiological_process
GO:0034166Toll-like receptor 10 signaling pathwayTASbiological_process
GO:0035666TRIF-dependent toll-like receptor signaling pathwayTASbiological_process
GO:0038095Fc-epsilon receptor signaling pathwayTASbiological_process
GO:0038123Toll-like receptor TLR1:TLR2 signaling pathwayTASbiological_process
GO:0038124Toll-like receptor TLR6:TLR2 signaling pathwayTASbiological_process
GO:0043204PerikaryonIEAcellular_component
GO:0043525Positive regulation of neuron apoptotic processIEAbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0045740Positive regulation of DNA replicationIEAbiological_process
GO:0051403Stress-activated MAPK cascadeTASbiological_process
GO:0071260Cellular response to mechanical stimulusIEPbiological_process
GO:0072709Cellular response to sorbitolIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.94487471600.10955146080.99999024730.6334586995

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0711181691
GSE13712_SHEARDown-0.5259309403
GSE13712_STATICDown-0.0685599633
GSE19018Up0.0075816612
GSE19899_A1Down-0.4991488587
GSE19899_A2Down-0.2688486829
PubMed_21979375_A1Down-0.2065483971
PubMed_21979375_A2Down-0.2027484309
GSE35957Down-0.0129591628
GSE36640Down-0.0782927765
GSE54402Down-0.1625693270
GSE9593Down-0.0179771451
GSE43922Down-0.3638707962
GSE24585Up0.0430913988
GSE37065Up0.0397013811
GSE28863_A1Up0.0727905905
GSE28863_A2Down-0.2581204153
GSE28863_A3Down-0.1970388102
GSE28863_A4Up0.1154575941
GSE48662Up0.2168745488

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-375MIMAT0000728MIRT019756MicroarrayFunctional MTI (Weak)20215506
hsa-miR-15b-5pMIMAT0000417MIRT023483CLASHFunctional MTI (Weak)23622248
hsa-miR-26b-5pMIMAT0000083MIRT028937MicroarrayFunctional MTI (Weak)19088304
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    • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-15b-5pMIMAT0000417NAhsa-miR-15b{Western blot}{downregulation by anti-miRNA oligonucleotide}19861690
hsa-miR-24-3pMIMAT0000080NAhsa-miR-24{Western blot}{downregulation by anti-miRNA oligonucleotide}19861690
hsa-miR-25-3pMIMAT0000081NAhsa-miR-25{Western blot}{downregulation by anti-miRNA oligonucleotide}19861690
hsa-miR-141-3pMIMAT0000432NAhsa-miR-141{Western blot}{downregulation by anti-miRNA oligonucleotide}19861690
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

20647589Comment on "Increased MKK4 abundance with replicative senescence is linked to the joint reduction of multiple microRNAs"
15107616We further explored other molecules involved in JNK pathway and found that both MKK4, another direct activator of JNK, and c-Jun, a direct substrate of JNK, have similar roles to MKK7
15107616Here we discuss the importance of the MKK4/MKK7-JNK-c-Jun pathway linking stress and developmental signals to cell proliferation, cell cycle progression, cellular senescence, and apoptosis including recent unpublished data from our lab
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