HCSGD entry for IFIH1
1. General information
| Official gene symbol | IFIH1 |
|---|---|
| Entrez ID | 64135 |
| Gene full name | interferon induced with helicase C domain 1 |
| Other gene symbols | Hlcd IDDM19 MDA-5 MDA5 RLR-2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0003725 | Double-stranded RNA binding | IDA TAS | molecular_function |
| GO:0003727 | Single-stranded RNA binding | IDA | molecular_function |
| GO:0004386 | Helicase activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0008270 | Zinc ion binding | IDA | molecular_function |
| GO:0009597 | Detection of virus | TAS | biological_process |
| GO:0009615 | Response to virus | TAS | biological_process |
| GO:0016032 | Viral process | IEA | biological_process |
| GO:0016925 | Protein sumoylation | IDA | biological_process |
| GO:0032480 | Negative regulation of type I interferon production | TAS | biological_process |
| GO:0032727 | Positive regulation of interferon-alpha production | IMP TAS | biological_process |
| GO:0032728 | Positive regulation of interferon-beta production | IMP TAS | biological_process |
| GO:0034344 | Regulation of type III interferon production | TAS | biological_process |
| GO:0039528 | Cytoplasmic pattern recognition receptor signaling pathway in response to virus | TAS | biological_process |
| GO:0042981 | Regulation of apoptotic process | IEA | biological_process |
| GO:0043021 | Ribonucleoprotein complex binding | IPI | molecular_function |
| GO:0045087 | Innate immune response | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0035091410 | 0.5135785760 | 0.1609130662 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.3648051636 |
| GSE13712_SHEAR | Up | 1.3023563542 |
| GSE13712_STATIC | Up | 1.1996495843 |
| GSE19018 | Up | 0.2822059223 |
| GSE19899_A1 | Down | -0.0157754428 |
| GSE19899_A2 | Down | -0.3253584323 |
| PubMed_21979375_A1 | Down | -0.1334615416 |
| PubMed_21979375_A2 | Up | 0.0215157495 |
| GSE35957 | Down | -1.1687088845 |
| GSE36640 | Up | 0.3651557834 |
| GSE54402 | Down | -0.5048494353 |
| GSE9593 | Up | 0.1475995450 |
| GSE43922 | Down | -0.2237542687 |
| GSE24585 | Up | 1.8256746569 |
| GSE37065 | Up | 1.8504161288 |
| GSE28863_A1 | Up | 0.3676595885 |
| GSE28863_A2 | Up | 2.5056861862 |
| GSE28863_A3 | Up | 0.0347688796 |
| GSE28863_A4 | Down | -0.0492956862 |
| GSE48662 | Down | -0.1960973846 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029703 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-424-5p | MIMAT0001341 | MIRT042455 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-15b-5p | MIMAT0000417 | MIRT046462 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-29b-3p | MIMAT0000100 | MIRT048368 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
