HCSGD entry for SDHD
1. General information
| Official gene symbol | SDHD |
|---|---|
| Entrez ID | 6392 |
| Gene full name | succinate dehydrogenase complex, subunit D, integral membrane protein |
| Other gene symbols | CBT1 CII-4 CWS3 PGL PGL1 QPs3 SDH4 cybS |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000104 | Succinate dehydrogenase activity | IDA | molecular_function |
| GO:0005739 | Mitochondrion | TAS | cellular_component |
| GO:0005740 | Mitochondrial envelope | IEA TAS | cellular_component |
| GO:0005743 | Mitochondrial inner membrane | IDA ISS TAS | cellular_component |
| GO:0005749 | Mitochondrial respiratory chain complex II | ISS | cellular_component |
| GO:0006099 | Tricarboxylic acid cycle | IDA IEA TAS | biological_process |
| GO:0009055 | Electron carrier activity | TAS | molecular_function |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0020037 | Heme binding | ISS | molecular_function |
| GO:0022904 | Respiratory electron transport chain | TAS | biological_process |
| GO:0044237 | Cellular metabolic process | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0048039 | Ubiquinone binding | ISS | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9509744691 | 0.1795299685 | 0.9999902473 | 0.8203742059 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0471850263 |
| GSE13712_SHEAR | Up | 0.0325930592 |
| GSE13712_STATIC | Up | 0.0078430863 |
| GSE19018 | Down | -0.0041347680 |
| GSE19899_A1 | Down | -0.0522344321 |
| GSE19899_A2 | Down | -0.1066246816 |
| PubMed_21979375_A1 | Down | -0.2098991806 |
| PubMed_21979375_A2 | Down | -0.0618774871 |
| GSE35957 | Down | -0.1237006126 |
| GSE36640 | Up | 0.0414342382 |
| GSE54402 | Down | -0.0944515682 |
| GSE9593 | Down | -0.1775644943 |
| GSE43922 | Down | -0.1148404373 |
| GSE24585 | Up | 0.0819176382 |
| GSE37065 | Up | 0.0198571789 |
| GSE28863_A1 | Down | -0.0736408493 |
| GSE28863_A2 | Down | -0.1100664342 |
| GSE28863_A3 | Down | -0.1951475840 |
| GSE28863_A4 | Up | 0.0601586923 |
| GSE48662 | Down | -0.5968104804 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| 2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol | DB04141 | EXPT00697 |
| UBIQUINONE-1 | DB08689 | - |
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 19506556 | Gene inactivation of components of the cytosolic chaperonin complex that induce increased longevity also causes somatic misexpression of PGL-1 |
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