HCSGD entry for SDHB
1. General information
| Official gene symbol | SDHB |
|---|---|
| Entrez ID | 6390 |
| Gene full name | succinate dehydrogenase complex, subunit B, iron sulfur (Ip) |
| Other gene symbols | CWS2 IP PGL4 SDH SDH1 SDH2 SDHIP |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005739 | Mitochondrion | IDA | cellular_component |
| GO:0005743 | Mitochondrial inner membrane | ISS TAS | cellular_component |
| GO:0005749 | Mitochondrial respiratory chain complex II | ISS | cellular_component |
| GO:0006099 | Tricarboxylic acid cycle | IEA TAS | biological_process |
| GO:0006105 | Succinate metabolic process | IEA | biological_process |
| GO:0008177 | Succinate dehydrogenase (ubiquinone) activity | IEA | molecular_function |
| GO:0009055 | Electron carrier activity | IEA | molecular_function |
| GO:0009060 | Aerobic respiration | TAS | biological_process |
| GO:0022904 | Respiratory electron transport chain | TAS | biological_process |
| GO:0044237 | Cellular metabolic process | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0048039 | Ubiquinone binding | ISS | molecular_function |
| GO:0051537 | 2 iron, 2 sulfur cluster binding | ISS | molecular_function |
| GO:0051538 | 3 iron, 4 sulfur cluster binding | ISS | molecular_function |
| GO:0051539 | 4 iron, 4 sulfur cluster binding | ISS | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5897497284 | 0.7784522017 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0804421236 |
| GSE13712_SHEAR | Up | 0.1446812168 |
| GSE13712_STATIC | Up | 0.1542874919 |
| GSE19018 | Up | 0.0415928790 |
| GSE19899_A1 | Up | 0.1745441142 |
| GSE19899_A2 | Up | 0.1669612709 |
| PubMed_21979375_A1 | Up | 0.1813602108 |
| PubMed_21979375_A2 | Up | 0.0229642568 |
| GSE35957 | Down | -0.2159131671 |
| GSE36640 | Down | -0.0070575434 |
| GSE54402 | Up | 0.2898348384 |
| GSE9593 | Down | -0.0098372079 |
| GSE43922 | Up | 0.1567938791 |
| GSE24585 | Down | -0.1378707602 |
| GSE37065 | Down | -0.0660372387 |
| GSE28863_A1 | Down | -0.0909477407 |
| GSE28863_A2 | Up | 0.0227232856 |
| GSE28863_A3 | Down | -0.1957577789 |
| GSE28863_A4 | Down | -0.0627762827 |
| GSE48662 | Down | -0.3596618328 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| 2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol | DB04141 | EXPT00697 |
| UBIQUINONE-1 | DB08689 | - |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-26b-5p | MIMAT0000083 | MIRT030097 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-125b-5p | MIMAT0000423 | MIRT046037 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 14512425 | Complex II defect via down-regulation of iron-sulfur subunit induces mitochondrial dysfunction and cell cycle delay in iron chelation-induced senescence-associated growth arrest |
| 14512425 | Furthermore, we found that the declined activity of complex II was mainly due to down-regulation of protein expression of the iron-sulfur subunit, which was associated with the irreversibility of the arrest |
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