HCSGD entry for SDHA
1. General information
| Official gene symbol | SDHA |
|---|---|
| Entrez ID | 6389 |
| Gene full name | succinate dehydrogenase complex, subunit A, flavoprotein (Fp) |
| Other gene symbols | CMD1GG FP PGL5 SDH1 SDH2 SDHF |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000104 | Succinate dehydrogenase activity | IMP | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005739 | Mitochondrion | IDA | cellular_component |
| GO:0005743 | Mitochondrial inner membrane | ISS TAS | cellular_component |
| GO:0005749 | Mitochondrial respiratory chain complex II | ISS TAS | cellular_component |
| GO:0006099 | Tricarboxylic acid cycle | IEA TAS | biological_process |
| GO:0006105 | Succinate metabolic process | IDA | biological_process |
| GO:0007399 | Nervous system development | IMP | biological_process |
| GO:0008177 | Succinate dehydrogenase (ubiquinone) activity | IEA | molecular_function |
| GO:0016491 | Oxidoreductase activity | IEA | molecular_function |
| GO:0016627 | Oxidoreductase activity, acting on the CH-CH group of donors | IEA | molecular_function |
| GO:0022900 | Electron transport chain | IEA | biological_process |
| GO:0022904 | Respiratory electron transport chain | IDA TAS | biological_process |
| GO:0044237 | Cellular metabolic process | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0050660 | Flavin adenine dinucleotide binding | IEA | molecular_function |
| GO:0055114 | Oxidation-reduction process | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1330364842 | 0.9092593405 | 0.7383405229 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.5096391479 |
| GSE13712_SHEAR | Up | 0.0244243959 |
| GSE13712_STATIC | Up | 0.1058367014 |
| GSE19018 | Up | 0.4203423179 |
| GSE19899_A1 | Up | 0.1202138933 |
| GSE19899_A2 | Up | 0.0888228691 |
| PubMed_21979375_A1 | Up | 0.5258829317 |
| PubMed_21979375_A2 | Up | 0.3719862479 |
| GSE35957 | Down | -0.5363020747 |
| GSE36640 | Down | -0.2693002062 |
| GSE54402 | Up | 0.1998697733 |
| GSE9593 | Down | -0.3274639388 |
| GSE43922 | Up | 0.1476639944 |
| GSE24585 | Up | 0.3304036405 |
| GSE37065 | Up | 0.1215678315 |
| GSE28863_A1 | Up | 0.1036171222 |
| GSE28863_A2 | Up | 0.2094056139 |
| GSE28863_A3 | Down | -0.1462509895 |
| GSE28863_A4 | Down | -0.0819322744 |
| GSE48662 | Down | -0.0630129040 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| 2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol | DB04141 | EXPT00697 |
| Carboxin | DB04657 | - |
| Thenoyltrifluoroacetone | DB04795 | - |
| UBIQUINONE-1 | DB08689 | - |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-760 | MIMAT0004957 | MIRT036723 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-222-3p | MIMAT0000279 | MIRT046836 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-106a-5p | MIMAT0000103 | MIRT048336 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-17-5p | MIMAT0000070 | MIRT050937 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
