HCSGD entry for CXCL12

1. General information

Official gene symbolCXCL12
Entrez ID6387
Gene full namechemokine (C-X-C motif) ligand 12
Other gene symbolsIRH PBSF SCYB12 SDF1 TLSF TPAR1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001569Patterning of blood vesselsIEAbiological_process
GO:0001666Response to hypoxiaIEAbiological_process
GO:0001667Ameboidal cell migrationIEAbiological_process
GO:0001764Neuron migrationIEAbiological_process
GO:0001938Positive regulation of endothelial cell proliferationIEAbiological_process
GO:0005102Receptor bindingTASmolecular_function
GO:0005576Extracellular regionTAScellular_component
GO:0005615Extracellular spaceIEAcellular_component
GO:0006874Cellular calcium ion homeostasisTASbiological_process
GO:0006935ChemotaxisTASbiological_process
GO:0006955Immune responseIEAbiological_process
GO:0007155Cell adhesionTASbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007186G-protein coupled receptor signaling pathwayTASbiological_process
GO:0007281Germ cell developmentIEAbiological_process
GO:0008009Chemokine activityTASmolecular_function
GO:0008015Blood circulationTASbiological_process
GO:0008045Motor neuron axon guidanceIEAbiological_process
GO:0008064Regulation of actin polymerization or depolymerizationTASbiological_process
GO:0008083Growth factor activityIEAmolecular_function
GO:0008344Adult locomotory behaviorIEAbiological_process
GO:0008354Germ cell migrationIEAbiological_process
GO:0009314Response to radiationIEAbiological_process
GO:0009408Response to heatIEAbiological_process
GO:0009612Response to mechanical stimulusIEAbiological_process
GO:0009615Response to virusTASbiological_process
GO:0009897External side of plasma membraneIEAcellular_component
GO:0022029Telencephalon cell migrationIEAbiological_process
GO:0031100Organ regenerationIEAbiological_process
GO:0033603Positive regulation of dopamine secretionIEAbiological_process
GO:0042098T cell proliferationIEAbiological_process
GO:0042379Chemokine receptor bindingIMPmolecular_function
GO:0043434Response to peptide hormoneIEAbiological_process
GO:0045236CXCR chemokine receptor bindingIDAmolecular_function
GO:0045666Positive regulation of neuron differentiationIEAbiological_process
GO:0048842Positive regulation of axon extension involved in axon guidanceIEAbiological_process
GO:0050930Induction of positive chemotaxisIEAbiological_process
GO:0051924Regulation of calcium ion transportIEAbiological_process
GO:0060326Cell chemotaxisTASbiological_process
GO:0070098Chemokine-mediated signaling pathwayIDAbiological_process
GO:0090026Positive regulation of monocyte chemotaxisIDAbiological_process
GO:1902230Negative regulation of intrinsic apoptotic signaling pathway in response to DNA damageIDAbiological_process
GO:2000107Negative regulation of leukocyte apoptotic processIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.91214807950.00002741540.99999024730.0092512821

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.9709319123
GSE13712_SHEARUp0.0743001734
GSE13712_STATICDown-0.0576589453
GSE19018Down-1.6340405966
GSE19899_A1Down-1.1602123578
GSE19899_A2Down-4.2262684245
PubMed_21979375_A1Down-3.0229811684
PubMed_21979375_A2Down-4.9569406978
GSE35957Down-2.2521260200
GSE36640Down-4.3639242485
GSE54402Down-2.7682923780
GSE9593Down-1.3171886548
GSE43922Down-1.6510470960
GSE24585Up0.3548425661
GSE37065Down-0.6189481850
GSE28863_A1Up0.7189029090
GSE28863_A2Up0.0002929320
GSE28863_A3Up0.3080959086
GSE28863_A4Up0.3699071087
GSE48662Down-0.4300605706

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

TinzaparinDB06822 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-23a-3pMIMAT0000078MIRT001776Luciferase reporter assay//Reporter assay;OtherFunctional MTI14697198
hsa-miR-31-5pMIMAT0000089MIRT004980Luciferase reporter assay//qRT-PCRNon-Functional MTI19524507
hsa-miR-126-5pMIMAT0000444MIRT007380Luciferase reporter assayFunctional MTI23396050
hsa-miR-126-3pMIMAT0000445MIRT007381Luciferase reporter assayFunctional MTI23396050
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    • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-23a-3pMIMAT00000781hsa-miR-23a14697198
hsa-miR-23a-3pMIMAT00000783hsa-miR-23a14697198
hsa-miR-23a-3pMIMAT00000782hsa-miR-23a14697198
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 7 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26391655In vivo, defective VSMC autophagy led to upregulation of MMP9, TGFB and CXCL12 and promoted postinjury neointima formation and diet-induced atherogenesis
23255557However, longer-term CLL-cell survival was enhanced when the cocultures were maintained in 5% O2 versus 21% O2 because of increased MSC proliferation and production of soluble prosurvival factors, such as CXCL12
21622994RESULTS: Uremic MSCs showed decreased expression of vascular endothelial growth factor (VEGF), VEGF receptor (VEGFR)1 and stromal cell-derived factor (SDF)-1alpha, increased cellular senescence, decreased proliferation, defects in migration in response to VEGF and SDF-1alpha and in vitro tube formation
20622962Quantitative real-time PCR validated the microarray data for selected genes: markedly increased genes were CXCL12, cadherin 6 (CDH6), and folate receptor 3 (FOLR3)
20622962The expression pattern of the selected genes was consistent with the microarray data except for CXCL12 and IGF2
19567818CTCE-9908 inhibited ovarian cancer cell migration to CXCL12, but on longer incubation, caused cell death in CXCR4-positive cells
16946301Neither wt CXCR4 nor mutated CXCR4 transgene expression itself enhanced apoptosis of neutrophils arising in transduced PBSC cultures even with stimulation by a CXCR4 agonist, stromal cell-derived factor-1 (SDF-1 [CXCL12])
15491683Loading of cholesterol to four-fold that of normal levels induced significant inhibition of intracellular calcium mobilization by both alphaCD3 and SDF-1alpha
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