HCSGD entry for BIK
1. General information
| Official gene symbol | BIK |
|---|---|
| Entrez ID | 638 |
| Gene full name | BCL2-interacting killer (apoptosis-inducing) |
| Other gene symbols | BIP1 BP4 NBK |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0006915 | Apoptotic process | TAS | biological_process |
| GO:0007283 | Spermatogenesis | IEA | biological_process |
| GO:0008584 | Male gonad development | IEA | biological_process |
| GO:0008637 | Apoptotic mitochondrial changes | IEA | biological_process |
| GO:0012505 | Endomembrane system | IEA | cellular_component |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0031966 | Mitochondrial membrane | IEA | cellular_component |
| GO:0032464 | Positive regulation of protein homooligomerization | IDA | biological_process |
| GO:0046982 | Protein heterodimerization activity | IEA | molecular_function |
| GO:0051400 | BH domain binding | IEA | molecular_function |
| GO:0090200 | Positive regulation of release of cytochrome c from mitochondria | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1960636868 | 0.9142444056 | 0.8576219638 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0291797415 |
| GSE13712_SHEAR | Up | 0.6348184605 |
| GSE13712_STATIC | Up | 0.2187648691 |
| GSE19018 | Down | -0.0180346110 |
| GSE19899_A1 | Up | 0.0839538641 |
| GSE19899_A2 | Up | 0.3615419222 |
| PubMed_21979375_A1 | Down | -0.0268313291 |
| PubMed_21979375_A2 | Down | -0.2404052815 |
| GSE35957 | Up | 0.3813480387 |
| GSE36640 | Up | 0.0554745689 |
| GSE54402 | Up | 0.2052286374 |
| GSE9593 | Up | 0.0637493280 |
| GSE43922 | Up | 0.0249586181 |
| GSE24585 | Up | 0.1370152462 |
| GSE37065 | Down | -0.1471663851 |
| GSE28863_A1 | Down | -0.0488095353 |
| GSE28863_A2 | Down | -0.0370353111 |
| GSE28863_A3 | Up | 0.4388241795 |
| GSE28863_A4 | Down | -0.0062777787 |
| GSE48662 | Down | -0.0800158175 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT019109 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-148b-3p | MIMAT0000759 | MIRT019414 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-9-5p | MIMAT0000441 | MIRT021409 | Microarray | Functional MTI (Weak) | 17612493 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
