HCSGD entry for CCL20
1. General information
| Official gene symbol | CCL20 |
|---|---|
| Entrez ID | 6364 |
| Gene full name | chemokine (C-C motif) ligand 20 |
| Other gene symbols | CKb4 LARC MIP-3-alpha MIP-3a MIP3A SCYA20 ST38 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005576 | Extracellular region | TAS | cellular_component |
| GO:0005615 | Extracellular space | IEA | cellular_component |
| GO:0006935 | Chemotaxis | TAS | biological_process |
| GO:0006954 | Inflammatory response | IEA | biological_process |
| GO:0006955 | Immune response | IEA | biological_process |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0007267 | Cell-cell signaling | TAS | biological_process |
| GO:0008009 | Chemokine activity | IEA | molecular_function |
| GO:0042466 | Chemokinesis | IEA | biological_process |
| GO:0042742 | Defense response to bacterium | IEA | biological_process |
| GO:0060326 | Cell chemotaxis | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0000068576 | 0.9890590631 | 0.0115777778 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 1.0928979290 |
| GSE13712_SHEAR | Up | 2.9826301233 |
| GSE13712_STATIC | Up | 2.7269327668 |
| GSE19018 | Up | 0.0798194712 |
| GSE19899_A1 | Up | 5.4668176497 |
| GSE19899_A2 | Up | 9.5742163874 |
| PubMed_21979375_A1 | Up | 9.3600852288 |
| PubMed_21979375_A2 | Up | 9.5118802371 |
| GSE35957 | Up | 0.6012394149 |
| GSE36640 | Up | 0.0493369887 |
| GSE54402 | Up | 3.2988583902 |
| GSE9593 | Up | 2.7889476629 |
| GSE43922 | Up | 4.0284491800 |
| GSE24585 | Up | 0.0648878283 |
| GSE37065 | Up | 1.1151996893 |
| GSE28863_A1 | Down | -0.0140607061 |
| GSE28863_A2 | Down | -0.0257347787 |
| GSE28863_A3 | Up | 0.2370240738 |
| GSE28863_A4 | Up | 0.1100384847 |
| GSE48662 | Down | -0.2012569706 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-21-5p | MIMAT0000076 | MIRT006199 | ELISA//Immunofluorescence//Luciferase reporter assay | Functional MTI | 22001440 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT017837 | Microarray | Functional MTI (Weak) | 18185580 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 23770676 | Coupling quantitative proteomics with small-molecule screens, we identified multiple SASP components mediating paracrine senescence, including TGF-beta family ligands, VEGF, CCL2 and CCL20 |
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