HCSGD entry for CCL19

1. General information

Official gene symbolCCL19
Entrez ID6363
Gene full namechemokine (C-C motif) ligand 19
Other gene symbolsCKb11 ELC MIP-3b MIP3B SCYA19
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001768Establishment of T cell polarityIDAbiological_process
GO:0001771Immunological synapse formationISSbiological_process
GO:0002407Dendritic cell chemotaxisIDAbiological_process
GO:0002408Myeloid dendritic cell chemotaxisIDAbiological_process
GO:0002606Positive regulation of dendritic cell antigen processing and presentationISSbiological_process
GO:0005576Extracellular regionTAScellular_component
GO:0005615Extracellular spaceIEAcellular_component
GO:0006874Cellular calcium ion homeostasisTASbiological_process
GO:0006954Inflammatory responseNASbiological_process
GO:0006955Immune responseIEAbiological_process
GO:0007154Cell communicationTASbiological_process
GO:0007257Activation of JUN kinase activityISSbiological_process
GO:0008009Chemokine activityIDA IEAmolecular_function
GO:0009615Response to virusTASbiological_process
GO:0010560Positive regulation of glycoprotein biosynthetic processISSbiological_process
GO:0014070Response to organic cyclic compoundIEAbiological_process
GO:0031295T cell costimulationISSbiological_process
GO:0031732CCR7 chemokine receptor bindingISSmolecular_function
GO:0031735CCR10 chemokine receptor bindingIDAmolecular_function
GO:0032320Positive regulation of Ras GTPase activityISSbiological_process
GO:0032735Positive regulation of interleukin-12 productionISSbiological_process
GO:0032760Positive regulation of tumor necrosis factor productionISSbiological_process
GO:0034695Response to prostaglandin EIDAbiological_process
GO:0042102Positive regulation of T cell proliferationISSbiological_process
GO:0042346Positive regulation of NF-kappaB import into nucleusIDAbiological_process
GO:0042379Chemokine receptor bindingIDAmolecular_function
GO:0043089Positive regulation of Cdc42 GTPase activityISSbiological_process
GO:0043123Positive regulation of I-kappaB kinase/NF-kappaB signalingIDAbiological_process
GO:0043552Positive regulation of phosphatidylinositol 3-kinase activityIDAbiological_process
GO:0045627Positive regulation of T-helper 1 cell differentiationISSbiological_process
GO:0045807Positive regulation of endocytosisISSbiological_process
GO:0045860Positive regulation of protein kinase activityIDAbiological_process
GO:0046330Positive regulation of JNK cascadeIDAbiological_process
GO:0048020CCR chemokine receptor bindingIPImolecular_function
GO:0048260Positive regulation of receptor-mediated endocytosisISSbiological_process
GO:0048469Cell maturationISSbiological_process
GO:0050718Positive regulation of interleukin-1 beta secretionISSbiological_process
GO:0050921Positive regulation of chemotaxisISSbiological_process
GO:0051209Release of sequestered calcium ion into cytosolIDAbiological_process
GO:0051897Positive regulation of protein kinase B signalingIDAbiological_process
GO:0060491Regulation of cell projection assemblyISSbiological_process
GO:0070374Positive regulation of ERK1 and ERK2 cascadeIDAbiological_process
GO:0071731Response to nitric oxideIDAbiological_process
GO:0072610Interleukin-12 secretionISSbiological_process
GO:0090023Positive regulation of neutrophil chemotaxisIDAbiological_process
GO:0097029Mature dendritic cell differentiationISSbiological_process
GO:2000107Negative regulation of leukocyte apoptotic processIDAbiological_process
GO:2000147Positive regulation of cell motilityIDAbiological_process
GO:2000549Positive regulation of dendritic cell dendrite assemblyISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.47389126550.85418820710.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1112057112
GSE13712_SHEARDown-0.1962556212
GSE13712_STATICDown-0.0672768766
GSE19018Down-0.0957017288
GSE19899_A1Down-0.1136895972
GSE19899_A2Down-0.0713553427
PubMed_21979375_A1Down-0.0373656366
PubMed_21979375_A2Up0.0597329367
GSE35957Up0.2956846857
GSE36640Up0.1742506361
GSE54402Up0.1161038389
GSE9593Down-0.0645208182
GSE43922Up0.0869226763
GSE24585Up0.0134338516
GSE37065Up0.0614221036
GSE28863_A1Up0.1797356698
GSE28863_A2Up0.1664177470
GSE28863_A3Up0.2836865252
GSE28863_A4Up0.0741023938
GSE48662Up0.1250170940

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT018017MicroarrayFunctional MTI (Weak)18185580
hsa-miR-148b-3pMIMAT0000759MIRT019331MicroarrayFunctional MTI (Weak)17612493
hsa-miR-9-5pMIMAT0000441MIRT021321MicroarrayFunctional MTI (Weak)17612493
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.